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Genome sequence of the opportunistic human pathogen Magnusiomyces capitatus

B. Brejová, H. Lichancová, F. Brázdovič, E. Hegedűsová, M. Forgáčová Jakúbková, V. Hodorová, V. Džugasová, A. Baláž, L. Zeiselová, A. Cillingová, M. Neboháčová, V. Raclavský, Ľ. Tomáška, BF. Lang, T. Vinař, J. Nosek,

. 2019 ; 65 (2) : 539-560. [pub] 20181119

Language English Country United States

Document type Journal Article

Persistent link   https://www.medvik.cz/link/bmc19034895

Grant support
APVV-14-0253 Agentúra na Podporu Výskumu a Vývoja
APVV-15-0022 Agentúra na Podporu Výskumu a Vývoja
VEGA 1/0458/18 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
VEGA 1/0333/15 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
VEGA 1/0052/16 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
VEGA 1/0684/16 Vedecká Grantová Agentúra MŠVVaŠ SR a SAV
UK/282/2018 Univerzita Komenského v Bratislave
UK/268/2018 Univerzita Komenského v Bratislave
UK/208/2018 Univerzita Komenského v Bratislave
RGPIN-2017-05411 Natural Sciences and Engineering Research Council of Canada
IGA_LF_2017_031 Univerzita Palackého v Olomouci
RVO 61989592 Univerzita Palackého v Olomouci

E-resources Online Full text

NLK ProQuest Central from 2003-01-01 to 1 year ago
Medline Complete (EBSCOhost) from 2000-01-01 to 1 year ago
Health & Medicine (ProQuest) from 2003-01-01 to 1 year ago

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PubMed 30456648
DOI 10.1007/s00294-018-0904-y
Knihovny.cz E-resources

The yeast Magnusiomyces capitatus is an opportunistic human pathogen causing rare yet severe infections, especially in patients with hematological malignancies. Here, we report the 20.2 megabase genome sequence of an environmental strain of this species as well as the genome sequences of eight additional isolates from human and animal sources providing an insight into intraspecies variation. The distribution of single-nucleotide variants is indicative of genetic recombination events, supporting evidence for sexual reproduction in this heterothallic yeast. Using RNAseq-aided annotation, we identified genes for 6518 proteins including several expanded families such as kexin proteases and Hsp70 molecular chaperones. Several of these families are potentially associated with the ability of M. capitatus to infect and colonize humans. For the purpose of comparative analysis, we also determined the genome sequence of a closely related yeast, Magnusiomyces ingens. The genome sequences of M. capitatus and M. ingens exhibit many distinct features and represent a basis for further comparative and functional studies.

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