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Nonerosive reflux disease: clinical concepts

CP. Gyawali, DE. Azagury, WW. Chan, SM. Chandramohan, JO. Clarke, N. de Bortoli, E. Figueredo, M. Fox, D. Jodorkovsky, A. Lazarescu, P. Malfertheiner, J. Martinek, KM. Murayama, R. Penagini, E. Savarino, KP. Shetler, E. Stein, RP. Tatum, J. Wu,

. 2018 ; 1434 (1) : 290-303. [pub] 20180515

Jazyk angličtina Země Spojené státy americké

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19035246

Esophageal symptoms can arise from gastroesophageal reflux disease (GERD) as well as other mucosal and motor processes, structural disease, and functional esophageal syndromes. GERD is the most common esophageal disorder, but diagnosis may not be straightforward when symptoms persist despite empiric acid suppressive therapy and when mucosal erosions are not seen on endoscopy (as for nonerosive reflux disease, NERD). Esophageal physiological tests (ambulatory pH or pH-impedance monitoring and manometry) can be of value in defining abnormal reflux burden and reflux-symptom association. NERD diagnosed on the basis of abnormal reflux burden on ambulatory reflux monitoring is associated with similar symptom response from antireflux therapy for erosive esophagitis. Acid suppression is the mainstay of therapy, and antireflux surgery has a definitive role in the management of persisting symptoms attributed to NERD, especially when the esophagogastric junction is compromised. Adjunctive approaches and complementary therapy may be of additional value in management. In this review, we describe the evaluation, diagnosis, differential diagnosis, and management of NERD.

Citace poskytuje Crossref.org

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$a Azagury, Dan E $u Department of Surgery, Stanford University, Stanford, California.
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