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Screening of medicinal plants traditionally used in Peruvian Amazon for in vitro antioxidant and anticancer potential
J. Tauchen, L. Huml, L. Bortl, I. Doskocil, V. Jarosova, P. Marsik, A. Frankova, ZM. Clavo Peralta, ME. Chuspe Zans, J. Havlik, O. Lapcik, L. Kokoska,
Language English Country England, Great Britain
Document type Journal Article, Video-Audio Media
- MeSH
- Alkaloids analysis MeSH
- Amaranthaceae chemistry MeSH
- Antioxidants chemistry pharmacology MeSH
- Caco-2 Cells MeSH
- Phenols analysis MeSH
- Antineoplastic Agents, Phytogenic pharmacology MeSH
- Plants, Medicinal chemistry MeSH
- Humans MeSH
- Cell Line, Tumor MeSH
- Oxidative Stress MeSH
- Plant Extracts chemistry pharmacology MeSH
- Medicine, Traditional MeSH
- Check Tag
- Humans MeSH
- Publication type
- Video-Audio Media MeSH
- Journal Article MeSH
- Geographicals
- Peru MeSH
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
References provided by Crossref.org
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- $a Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant. The results justify the traditional medicinal use of this plant. Our findings further suggest that D. ambrosioides might serve as a prospective material for further development of novel plant-based antioxidant and/or anti-proliferative agents. Detailed analysis of chemical composition together with toxicology assessments and in vivo antioxidant/anti-proliferative activity of this plant should be carried out in order to verify its potential practical use.
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- $a Huml, Lukas $u b Department of Chemistry of Natural Compounds , University of Chemistry and Technology Prague , Prague , Czech Republic. d Students for the Living Amazon o.p.s. , Prague , Czech Republic.
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- $a Bortl, Ludvik $u c Department of Crop Sciences and Agroforestry , Czech University of Life Sciences Prague , Prague , Czech Republic. d Students for the Living Amazon o.p.s. , Prague , Czech Republic. e Prague Botanical Garden , Prague , Czech Republic.
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- $a Doskocil, Ivo $u f Department of Microbiology, Nutrition and Dietetics , Czech University of Life Sciences Prague , Prague , Czech Republic.
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- $a Clavo Peralta, Zoyla Mirella $u g Estación de Instituto Veterinario de Investigaciones Tropicales y de Altura , Universidad Nacional Mayor de San Marcos , Lima , Peru.
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- $a Chuspe Zans, Maria-Elena $u h Escuela de Ingeniería Agroforestal Acuícola , Universidad Nacional Intercultural de la Amazonia , Pucallpa , Peru.
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- $a Lapcik, Oldrich $u b Department of Chemistry of Natural Compounds , University of Chemistry and Technology Prague , Prague , Czech Republic.
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- $a Kokoska, Ladislav $u c Department of Crop Sciences and Agroforestry , Czech University of Life Sciences Prague , Prague , Czech Republic.
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