• Je něco špatně v tomto záznamu ?

Gut as an emerging organ for the treatment of diabetes: focus on mechanism of action of bariatric and endoscopic interventions

M. Haluzík, H. Kratochvílová, D. Haluzíková, M. Mráz,

. 2018 ; 237 (1) : R1-R17. [pub] 20180129

Jazyk angličtina Země Anglie, Velká Británie

Typ dokumentu časopisecké články, práce podpořená grantem, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc19035426

Increasing worldwide prevalence of type 2 diabetes mellitus and its accompanying pathologies such as obesity, arterial hypertension and dyslipidemia represents one of the most important challenges of current medicine. Despite intensive efforts, high percentage of patients with type 2 diabetes does not achieve treatment goals and struggle with increasing body weight and poor glucose control. While novel classes of antidiabetic medications such as incretin-based therapies and gliflozins have some favorable characteristics compared to older antidiabetics, the only therapeutic option shown to substantially modify the progression of diabetes or to achieve its remission is bariatric surgery. Its efficacy in the treatment of diabetes is well established, but the exact underlying modes of action are still only partially described. They include restriction of food amount, enhanced passage of chymus into distal part of small intestine with subsequent modification of gastrointestinal hormones and bile acids secretion, neural mechanisms, changes in gut microbiota and many other possible mechanisms underscoring the importance of the gut in the regulation of glucose metabolism. In addition to bariatric surgery, less-invasive endoscopic methods based on the principles of bariatric surgery were introduced and showed promising results. This review highlights the role of the intestine in the regulation of glucose homeostasis focusing on the mechanisms of action of bariatric and especially endoscopic methods of the treatment of diabetes. A better understanding of these mechanisms may lead to less invasive endoscopic treatments of diabetes and obesity that may complement and widen current therapeutic options.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc19035426
003      
CZ-PrNML
005      
20191015114233.0
007      
ta
008      
191007s2018 enk f 000 0|eng||
009      
AR
024    7_
$a 10.1530/JOE-17-0438 $2 doi
035    __
$a (PubMed)29378901
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a enk
100    1_
$a Haluzík, Martin $u Centre for Experimental MedicineInstitute for Clinical and Experimental Medicine, Prague, Czech Republic halm@ikem.cz. Diabetes CentreInstitute for Clinical and Experimental Medicine, Prague, Czech Republic. Department of Medical Biochemistry and Laboratory DiagnosticsGeneral University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic.
245    10
$a Gut as an emerging organ for the treatment of diabetes: focus on mechanism of action of bariatric and endoscopic interventions / $c M. Haluzík, H. Kratochvílová, D. Haluzíková, M. Mráz,
520    9_
$a Increasing worldwide prevalence of type 2 diabetes mellitus and its accompanying pathologies such as obesity, arterial hypertension and dyslipidemia represents one of the most important challenges of current medicine. Despite intensive efforts, high percentage of patients with type 2 diabetes does not achieve treatment goals and struggle with increasing body weight and poor glucose control. While novel classes of antidiabetic medications such as incretin-based therapies and gliflozins have some favorable characteristics compared to older antidiabetics, the only therapeutic option shown to substantially modify the progression of diabetes or to achieve its remission is bariatric surgery. Its efficacy in the treatment of diabetes is well established, but the exact underlying modes of action are still only partially described. They include restriction of food amount, enhanced passage of chymus into distal part of small intestine with subsequent modification of gastrointestinal hormones and bile acids secretion, neural mechanisms, changes in gut microbiota and many other possible mechanisms underscoring the importance of the gut in the regulation of glucose metabolism. In addition to bariatric surgery, less-invasive endoscopic methods based on the principles of bariatric surgery were introduced and showed promising results. This review highlights the role of the intestine in the regulation of glucose homeostasis focusing on the mechanisms of action of bariatric and especially endoscopic methods of the treatment of diabetes. A better understanding of these mechanisms may lead to less invasive endoscopic treatments of diabetes and obesity that may complement and widen current therapeutic options.
650    _2
$a zvířata $7 D000818
650    _2
$a bariatrická chirurgie $x metody $x trendy $7 D050110
650    _2
$a krevní glukóza $x metabolismus $7 D001786
650    _2
$a diabetes mellitus 2. typu $x mikrobiologie $x chirurgie $7 D003924
650    _2
$a gastrointestinální endoskopie $x metody $x trendy $7 D016099
650    _2
$a gastrointestinální hormony $x terapeutické užití $7 D005768
650    _2
$a střevní mikroflóra $x fyziologie $7 D000069196
650    _2
$a lidé $7 D006801
650    _2
$a střeva $x mikrobiologie $x fyziologie $x chirurgie $7 D007422
650    _2
$a obezita $x metabolismus $x patologie $x chirurgie $7 D009765
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
655    _2
$a přehledy $7 D016454
700    1_
$a Kratochvílová, Helena $u Centre for Experimental MedicineInstitute for Clinical and Experimental Medicine, Prague, Czech Republic. Department of Medical Biochemistry and Laboratory DiagnosticsGeneral University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic.
700    1_
$a Haluzíková, Denisa $u Department of Sports MedicineGeneral University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic.
700    1_
$a Mráz, Miloš $u Diabetes CentreInstitute for Clinical and Experimental Medicine, Prague, Czech Republic. Department of Medical Biochemistry and Laboratory DiagnosticsGeneral University Hospital, Charles University in Prague, 1st Faculty of Medicine, Prague, Czech Republic.
773    0_
$w MED00002653 $t The Journal of endocrinology $x 1479-6805 $g Roč. 237, č. 1 (2018), s. R1-R17
856    41
$u https://pubmed.ncbi.nlm.nih.gov/29378901 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20191007 $b ABA008
991    __
$a 20191015114658 $b ABA008
999    __
$a ok $b bmc $g 1452086 $s 1073976
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2018 $b 237 $c 1 $d R1-R17 $e 20180129 $i 1479-6805 $m Journal of Endocrinology $n J Endocrinol $x MED00002653
LZP    __
$a Pubmed-20191007

Najít záznam

Citační ukazatele

Možnosti archivace