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Membrane insertion of-and membrane potential sensing by-semiconductor voltage nanosensors: Feasibility demonstration

K. Park, Y. Kuo, V. Shvadchak, A. Ingargiola, X. Dai, L. Hsiung, W. Kim, H. Zhou, P. Zou, AJ. Levine, J. Li, S. Weiss,

. 2018 ; 4 (1) : e1601453. [pub] 20180112

Language English Country United States

Document type Journal Article, Research Support, N.I.H., Extramural

Persistent link   https://www.medvik.cz/link/bmc19035443

Grant support
R01 GM071940 NIGMS NIH HHS - United States
S10 RR023057 NCRR NIH HHS - United States

We developed membrane voltage nanosensors that are based on inorganic semiconductor nanoparticles. We provide here a feasibility study for their utilization. We use a rationally designed peptide to functionalize the nanosensors, imparting them with the ability to self-insert into a lipid membrane with a desired orientation. Once inserted, these nanosensors could sense membrane potential via the quantum confined Stark effect, with a single-particle sensitivity. With further improvements, these nanosensors could potentially be used for simultaneous recording of action potentials from multiple neurons in a large field of view over a long duration and for recording electrical signals on the nanoscale, such as across one synapse.

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$a Kuo, Yung $u Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Shvadchak, Volodymyr $u Institute of Organic Chemistry and Biochemistry AS CR, Prague 166-10, Czech Republic.
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$a Ingargiola, Antonino $u Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Dai, Xinghong $u Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Hsiung, Lawrence $u Department of Chemical and Biomolecular Engineering, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Kim, Wookyeom $u Department of Ecology and Evolutionary Biology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Zhou, Hong $u Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, Los Angeles, CA 90095, USA. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Zou, Peng $u Department of Chemistry and Chemical Biology, Harvard University, MA 02138, USA.
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$a Levine, Alex J $u Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Physics, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Li, Jack $u Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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$a Weiss, Shimon $u Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA. California NanoSystems Institute, University of California, Los Angeles, Los Angeles, CA 90095, USA. Department of Physiology, University of California, Los Angeles, Los Angeles, CA 90095, USA.
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