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Association of kidney fibrosis with urinary peptides: a path towards non-invasive liquid biopsies?
P. Magalhães, M. Pejchinovski, K. Markoska, M. Banasik, M. Klinger, D. Švec-Billá, I. Rychlík, M. Rroji, A. Restivo, G. Capasso, F. Bob, A. Schiller, A. Ortiz, MV. Perez-Gomez, P. Cannata, MD. Sanchez-Niño, R. Naumovic, V. Brkovic, M....
Jazyk angličtina Země Anglie, Velká Británie
Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem
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Directory of Open Access Journals
od 2011
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od 2011
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od 2011-12-01
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od 2011
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od 2011
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od 2011-01-01
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od 2011-01-01
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od 2011
- MeSH
- chronická renální insuficience patologie moč MeSH
- dospělí MeSH
- elektroforéza kapilární MeSH
- fibróza patologie moč MeSH
- hmotnostní spektrometrie MeSH
- kolagen moč MeSH
- ledviny patologie MeSH
- lidé středního věku MeSH
- lidé MeSH
- peptidy moč MeSH
- tekutá biopsie metody MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- práce podpořená grantem MeSH
Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues. The urinary proteome was analysed by capillary electrophoresis coupled to mass spectrometry. CKD273 displayed a significant and positive correlation with the degree of fibrosis (Rho = 0.430, P = 0.0044), while the routinely used parameters (glomerular filtration rate, urine albumin-to-creatinine ratio and urine protein-to-creatinine ratio) did not (Rho = -0.222; -0.137; -0.070 and P = 0.16; 0.39; 0.66, respectively). We identified seven fibrosis-associated peptides displaying a significant and negative correlation with the degree of fibrosis. All peptides were collagen fragments, suggesting that these may be causally related to the observed accumulation of ECM in the kidneys. CKD273 and specific peptides are significantly associated with kidney fibrosis; such an association could not be detected by other biomarkers for CKD. These non-invasive fibrosis-related biomarkers can potentially be implemented in future trials.
1st Department of Medicine 3rd Faculty of Medicine Charles University Prague Czech Republic
Biotechnology Division Biomedical Research Foundation Academy of Athens Athens Greece
Department of Nephrology and Transplantation Medicine Wroclaw Medical University Wroclaw Poland
Department of Nephrology Medical Faculty University of Skopje Skopje Macedonia
Department of Nephrology University Hospital Center Mother Teresa Tirana Albania
Department of Nephrology University of Campania Luigi Vanvitelli Naples Italy
Department of Pediatric Nephrology Hannover Medical School Hannover Germany
IIS Fundacion Jimenez Diaz UAM Madrid Spain
Institute of Cardiovascular and Medical Sciences University of Glasgow Glasgow UK
Macedonian Academy of Sciences and Arts Skopje Macedonia
Citace poskytuje Crossref.org
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- $a Magalhães, Pedro $u Mosaiques Diagnostics GmbH, Hannover, Germany. Department of Pediatric Nephrology, Hannover Medical School, Hannover, Germany.
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- $a Chronic kidney disease (CKD) is a prevalent cause of morbidity and mortality worldwide. A hallmark of CKD progression is renal fibrosis characterized by excessive accumulation of extracellular matrix (ECM) proteins. In this study, we aimed to investigate the correlation of the urinary proteome classifier CKD273 and individual urinary peptides with the degree of fibrosis. In total, 42 kidney biopsies and urine samples were examined. The percentage of fibrosis per total tissue area was assessed in Masson trichrome stained kidney tissues. The urinary proteome was analysed by capillary electrophoresis coupled to mass spectrometry. CKD273 displayed a significant and positive correlation with the degree of fibrosis (Rho = 0.430, P = 0.0044), while the routinely used parameters (glomerular filtration rate, urine albumin-to-creatinine ratio and urine protein-to-creatinine ratio) did not (Rho = -0.222; -0.137; -0.070 and P = 0.16; 0.39; 0.66, respectively). We identified seven fibrosis-associated peptides displaying a significant and negative correlation with the degree of fibrosis. All peptides were collagen fragments, suggesting that these may be causally related to the observed accumulation of ECM in the kidneys. CKD273 and specific peptides are significantly associated with kidney fibrosis; such an association could not be detected by other biomarkers for CKD. These non-invasive fibrosis-related biomarkers can potentially be implemented in future trials.
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