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The Polymorphisms of the Peroxisome-Proliferator Activated Receptors' Alfa Gene Modify the Aerobic Training Induced Changes of Cholesterol and Glucose

A. Maciejewska-Skrendo, M. Buryta, W. Czarny, P. Król, P. Stastny, M. Petr, K. Safranow, M. Sawczuk,

. 2019 ; 8 (7) : . [pub] 20190717

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19035934

Grantová podpora
UNCE/HUM/032 Univerzita Karlova v Praze
UM0-2012/07/B/NZ7/ 01155 Polish Ministry of Science and Higher Education

BACKGROUND: PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage. PPARA gene polymorphisms may be crucial for maintaining lipid homeostasis and in this way, being responsible for developing specific training-induced physiological reactions. Therefore, we have decided to check if post-training changes of body mass measurements as well as chosen biochemical parameters are modulation by the PPARA genotypes. METHODS: We have examined the genotype and alleles' frequencies (described in PPARA rs1800206 and rs4253778 polymorphic sites) in 168 female participants engaged in a 12-week training program. Body composition and biochemical parameters were measured before and after the completion of a whole training program. RESULTS: Statistical analyses revealed that PPARA intron 7 rs4253778 CC genotype modulate training response by increasing low-density lipoproteins (LDL) and glucose concentration, while PPARA Leu162Val rs1800206 CG genotype polymorphism interacts in a decrease in high-density lipoproteins (HDL) concentration. CONCLUSIONS: Carriers of PPARA intron 7 rs4253778 CC genotype and Leu162Val rs1800206 CG genotype might have potential negative training-induced cholesterol and glucose changes after aerobic exercise.

Citace poskytuje Crossref.org

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$a BACKGROUND: PPARα is a transcriptional factor that controls the expression of genes involved in fatty acid metabolism, including fatty acid transport, uptake by the cells, intracellular binding, and activation, as well as catabolism (particularly mitochondrial fatty acid oxidation) or storage. PPARA gene polymorphisms may be crucial for maintaining lipid homeostasis and in this way, being responsible for developing specific training-induced physiological reactions. Therefore, we have decided to check if post-training changes of body mass measurements as well as chosen biochemical parameters are modulation by the PPARA genotypes. METHODS: We have examined the genotype and alleles' frequencies (described in PPARA rs1800206 and rs4253778 polymorphic sites) in 168 female participants engaged in a 12-week training program. Body composition and biochemical parameters were measured before and after the completion of a whole training program. RESULTS: Statistical analyses revealed that PPARA intron 7 rs4253778 CC genotype modulate training response by increasing low-density lipoproteins (LDL) and glucose concentration, while PPARA Leu162Val rs1800206 CG genotype polymorphism interacts in a decrease in high-density lipoproteins (HDL) concentration. CONCLUSIONS: Carriers of PPARA intron 7 rs4253778 CC genotype and Leu162Val rs1800206 CG genotype might have potential negative training-induced cholesterol and glucose changes after aerobic exercise.
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$a Buryta, Maciej $u Department of Molecular Biology, Faculty of Physical Education, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
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$a Czarny, Wojciech $u Department of Anatomy and Anthropology, Faculty of Physical Education, University of Rzeszow, 35-310 Rzeszow, Poland.
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$a Król, Pawel $u Department of Anatomy and Anthropology, Faculty of Physical Education, University of Rzeszow, 35-310 Rzeszow, Poland.
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$a Stastny, Petr $u Department of Sport Games, Faulty of Physical Education and Sport, Charles University, 162-52 Prague, Czech Republic. stastny@ftvs.cuni.cz.
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$a Petr, Miroslav $u Department of Sport Games, Faulty of Physical Education and Sport, Charles University, 162-52 Prague, Czech Republic.
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$a Safranow, Krzysztof $u Department of Biochemistry and Medical Chemistry, Pomeranian Medical University, 70-204 Szczecin, Poland.
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$a Sawczuk, Marek $u Unit of Physical Medicine, Faculty of Tourism and Recreation, Gdansk University of Physical Education and Sport, 80-336 Gdansk, Poland.
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