Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats

J. Zicha, S. Hojná, L. Kopkan, L. Červenka, I. Vaněčková

. 2019 ; 68 (2) : 329-334. [pub] 20190430

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc19042122

Grantová podpora
NV15-25396A MZ0 CEP - Centrální evidence projektů

The insertion of mouse renin gene (Ren-2) into the genome of normotensive rats causes a spontaneous rise of blood pressure (BP), leading to an angiotensin II (Ang II)-dependent form of hypertension in transgenic (mRen-2)27 rats (TGR). However, enhanced sympathetic BP component was demonstrated in heterozygous TGR aged 20 weeks. In the present study we used another model, i.e. Cyp1a1-Ren-2 transgenic rats (iTGR) in which hypertension can be induced by natural xenobiotic indole-3 carbinol (I3C) added to the diet. We investigated whether the development of high blood pressure (BP) in 5-month-old iTGR animals fed I3C diet for 10 days is solely due to enhanced Ang II-dependent vasoconstriction or whether enhanced sympathetic vasoconstriction also participates in BP maintenance in this form of hypertension. Using acute sequential blockade of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and NO synthase (NOS) we have demonstrated that the observed gradual increase of BP in iTGR fed I3C diet was entirely due to the augmentation of Ang II-dependent BP component without significant changes of sympathetic BP component. Thus, the hypertension in iTGR resembles to that of homozygous TGR in which high BP was entirely dependent on Ang II-dependent vasoconstriction. Moreover, our measurements of acute BP response to Rho kinase inhibitor fasudil in animals subjected to a combined blockade of RAS, SNS and NOS indicated the attenuation of basal calcium sensitization in both iTGR and homozygous TGR.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc19042122
003      
CZ-PrNML
005      
20191210084616.0
007      
ta
008      
191205s2019 xr d f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934151 $2 doi
035    __
$a (PubMed)31037948
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Zicha, Josef, $u Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic $d 1950- $7 jk01152609
245    14
$a The absence of sympathoexcitation during the development of hypertension in Cyp1a1 Ren-2 transgenic rats / $c J. Zicha, S. Hojná, L. Kopkan, L. Červenka, I. Vaněčková
504    __
$a Literatura
520    9_
$a The insertion of mouse renin gene (Ren-2) into the genome of normotensive rats causes a spontaneous rise of blood pressure (BP), leading to an angiotensin II (Ang II)-dependent form of hypertension in transgenic (mRen-2)27 rats (TGR). However, enhanced sympathetic BP component was demonstrated in heterozygous TGR aged 20 weeks. In the present study we used another model, i.e. Cyp1a1-Ren-2 transgenic rats (iTGR) in which hypertension can be induced by natural xenobiotic indole-3 carbinol (I3C) added to the diet. We investigated whether the development of high blood pressure (BP) in 5-month-old iTGR animals fed I3C diet for 10 days is solely due to enhanced Ang II-dependent vasoconstriction or whether enhanced sympathetic vasoconstriction also participates in BP maintenance in this form of hypertension. Using acute sequential blockade of renin-angiotensin system (RAS), sympathetic nervous system (SNS) and NO synthase (NOS) we have demonstrated that the observed gradual increase of BP in iTGR fed I3C diet was entirely due to the augmentation of Ang II-dependent BP component without significant changes of sympathetic BP component. Thus, the hypertension in iTGR resembles to that of homozygous TGR in which high BP was entirely dependent on Ang II-dependent vasoconstriction. Moreover, our measurements of acute BP response to Rho kinase inhibitor fasudil in animals subjected to a combined blockade of RAS, SNS and NOS indicated the attenuation of basal calcium sensitization in both iTGR and homozygous TGR.
650    _2
$a angiotensin II $x genetika $x metabolismus $7 D000804
650    _2
$a zvířata $7 D000818
650    _2
$a krevní tlak $x fyziologie $7 D001794
650    _2
$a cytochrom P-450 CYP1A1 $x genetika $x metabolismus $7 D019363
650    _2
$a hypertenze $x genetika $x patofyziologie $7 D006973
650    _2
$a mužské pohlaví $7 D008297
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani transgenní $7 D055647
650    _2
$a renin $x genetika $x metabolismus $7 D012083
650    _2
$a renin-angiotensin systém $x fyziologie $7 D012084
650    _2
$a sympatický nervový systém $x fyziologie $7 D013564
650    _2
$a vazokonstrikce $x fyziologie $7 D014661
655    _2
$a časopisecké články $7 D016428
700    1_
$a Hojná, Silvie, $d 1979- $7 xx0074203 $u Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
700    1_
$a Kopkan, Libor $7 xx0107287 $u Institute of¨Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Červenka, Luděk, $d 1967- $7 xx0037105 $u Institute of Clinical and Experimental Medicine, Prague, Czech Republic
700    1_
$a Vaněčková, Ivana, $d 1964- $7 xx0030586 $u Institute of Physiology of the Czech Academy of Sciences, Prague, Czech Republic
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, č. 2 (2019), s. 329-334
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31037948 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20191205 $b ABA008
991    __
$a 20191209104417 $b ABA008
999    __
$a ok $b bmc $g 1472691 $s 1080765
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c 2 $d 329-334 $e 20190430 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
GRA    __
$a NV15-25396A $p MZ0
LZP    __
$b NLK118 $a Pubmed-20191205

Najít záznam

Citační ukazatele

Možnosti archivace