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The extracellular matrix and Ca(2+) signaling mechanisms

S. Filip, J. Mokrý, O. Forostyak, G. Dayanithi

. 2019 ; 68 (2) : 161-170. [pub] 20190110

Language English Country Czech Republic

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc19042125

The extracellular matrix (ECM) consists of proteins, glycosaminoglycans and glycoproteins, that support the dynamic interactions between cells, including intercellular communication, cell attachment, cell differentiation, cell growth and migration. As such, the ECM represents an essential and very sensitive system within the tissue microenvironment that is involved in processes such as tissue regeneration and carcinogenesis. The aim of the present review is to evaluate its diversity through Ca(2+) signaling and its role in muscle cell function. Here, we discuss some methodological approaches dissecting Ca(2+) handling mechanisms in myogenic and non-myogenic cells, e.g. the importance of Ca(2+) and calpains in muscle dystrophy. We also consider the reconstruction of skeletal muscle by colonization of decellularized ECM with muscle-derived cells isolated from skeletal muscle. Therefore, it is necessary to establish new methodological procedures based on Ca(2+) signaling in skeletal muscle cells and their effect on ECM homeostasis, allowing the monitoring of skeletal muscle reconstruction and organ repair.

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Literatura

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$a The extracellular matrix (ECM) consists of proteins, glycosaminoglycans and glycoproteins, that support the dynamic interactions between cells, including intercellular communication, cell attachment, cell differentiation, cell growth and migration. As such, the ECM represents an essential and very sensitive system within the tissue microenvironment that is involved in processes such as tissue regeneration and carcinogenesis. The aim of the present review is to evaluate its diversity through Ca(2+) signaling and its role in muscle cell function. Here, we discuss some methodological approaches dissecting Ca(2+) handling mechanisms in myogenic and non-myogenic cells, e.g. the importance of Ca(2+) and calpains in muscle dystrophy. We also consider the reconstruction of skeletal muscle by colonization of decellularized ECM with muscle-derived cells isolated from skeletal muscle. Therefore, it is necessary to establish new methodological procedures based on Ca(2+) signaling in skeletal muscle cells and their effect on ECM homeostasis, allowing the monitoring of skeletal muscle reconstruction and organ repair.
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$a Mokrý, Jaroslav, $d 1964- $7 jn20000620235 $u Department of Histology and Embryology, Faculty of Medicine, Charles University, Hradec Kralove, Czech Republic
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$a Forostyak, Oksana, $d 1982- $7 xx0242979 $u Department of Neurochemistry, Institute of Experimental Medicine, Czech Academy of Sciences,Prague, Czech Republic
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$a Dayanithi, Govindan $7 _AN091139 $u Department of Pharmacology and Toxicology, Faculty of Medicine, Charles University, Pilsen, Czech Republic; Unité de recherche U1198, Institut National de la Santé et de la Recherche Médicale, Université de Montpellier, Montpellier, France and Ecole Pratique des Hautes Etudes - Sorbonne, Paris, France
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