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Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study
PEH. Jensen, C. Warnke, K. Ingenhoven, L. Piccoli, M. Gasis, C. Hermanrud, BM. Fernandez-Rodriguez, M. Ryner, D. Kramer, J. Link, R. Ramanujam, M. Auer, D. Buck, V. Grummel, E. Bertotti, N. Fissolo, B. Oliver-Martos, P. Nytrova, M. Khalil, M....
Journal of neuroimmunology.
2019 ;
326 (-) :
19-27.
[pub] 20181107
Jazyk angličtina Země Nizozemsko
Typ dokumentu srovnávací studie, časopisecké články, multicentrická studie, pozorovací studie, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc19045133
- MeSH
- biotest MeSH
- ELISA MeSH
- imunologické faktory imunologie terapeutické užití MeSH
- interferon beta imunologie terapeutické užití MeSH
- lidé MeSH
- neutralizační testy metody MeSH
- neutralizující protilátky krev MeSH
- roztroušená skleróza krev farmakoterapie MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
- pozorovací studie MeSH
- práce podpořená grantem MeSH
- srovnávací studie MeSH
Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.
Assistance Publique Hôpitaux de Paris Hôpital Paul Brousse Villejuif France
Clinic for Neurology 2 Kepler University Clinic Med Campus 3 Linz Austria
Department of Clinical Neuroscience Karolinska Institutet Stockholm Sweden
Department of Neurology Medical University of Graz Graz Austria
Department of Neurology Technische Universität München Munich Germany
Department of Neurology University Hospital Köln Köln Germany
GlaxoSmithKline R and D Uxbridge Middlesex United Kingdom
Hospital Universitari Vall d'Hebron Centre d'Esclerosi Múltiple de Catalunya Barcelona Spain
Innsbruck Medical University Innsbruck Austria
INSERM UMR 996 Univ Paris Sud Faculty of Pharmacy Université Paris Saclay Châtenay Malabry France
Ipsen Biopharm Ltd Berkshire United Kingdom
KTH Royal Institute of Technology Stockholm Sweden
Merck NBE Bioanalytics Ivrea Colleretto Giacosa Italy
Munich Cluster for systems Neurology Munich Germany
Sanofi Aventis Germany Frankfurt Am Main Germany
University of Düsseldorf Medical Faculty Department of Neurology Düsseldorf Germany
Citace poskytuje Crossref.org
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- $a Jensen, Poul Erik H $u Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: poul.erik.h.jensen@regionh.dk.
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- $a Detection and kinetics of persistent neutralizing anti-interferon-beta antibodies in patients with multiple sclerosis. Results from the ABIRISK prospective cohort study / $c PEH. Jensen, C. Warnke, K. Ingenhoven, L. Piccoli, M. Gasis, C. Hermanrud, BM. Fernandez-Rodriguez, M. Ryner, D. Kramer, J. Link, R. Ramanujam, M. Auer, D. Buck, V. Grummel, E. Bertotti, N. Fissolo, B. Oliver-Martos, P. Nytrova, M. Khalil, M. Guger, S. Rathmaier, C. Sievers-Stober, RLP. Lindberg, S. Hässler, D. Bachelet, O. Aktas, N. Donnellan, A. Lawton, B. Hemmer, EK. Havrdova, B. Kieseier, HP. Hartung, M. Comabella, X. Montalban, T. Derfuss, F. Sellebjerg, P. Dönnes, M. Pallardy, S. Spindeldreher, P. Broët, F. Deisenhammer, A. Fogdell-Hahn, PS. Sorensen, ABIRISK Consortium,
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- $a Two validated assays, a bridging ELISA and a luciferase-based bioassay, were compared for detection of anti-drug antibodies (ADA) against interferon-beta (IFN-β) in patients with multiple sclerosis. Serum samples were tested from patients enrolled in a prospective study of 18 months. In contrast to the ELISA, when IFN-β-specific rabbit polyclonal and human monoclonal antibodies were tested, the bioassay was the more sensitive to detect IFN-β ADA in patients' sera. For clinical samples, selection of method of ELISA should be evaluated prior to the use of a multi-tiered approach. A titer threshold value is reported that may be used as a predictor for persistently positive neutralizing ADA.
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- $a Warnke, Clemens $u Department of Neurology, University Hospital Köln, Köln, Germany; University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: clemens.warnke@uk-koeln.de.
- 700 1_
- $a Ingenhoven, Kathleen $u University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: Kathleen.Ingenhoven@med.uni-duesseldorf.de.
- 700 1_
- $a Piccoli, Luca $u Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland. Electronic address: luca.piccoli@irb.usi.ch.
- 700 1_
- $a Gasis, Marcia $u University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: gasis@hhu.de.
- 700 1_
- $a Hermanrud, Christina $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: christina.hermanrud@ki.se.
- 700 1_
- $a Fernandez-Rodriguez, Blanca M $u Università della Svizzera italiana (USI), Faculty of Biomedical Sciences, Institute for Research in Biomedicine, Bellinzona, Switzerland. Electronic address: blanca.fernandez@irb.usi.ch.
- 700 1_
- $a Ryner, Malin $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Kramer, Daniel $u Sanofi-Aventis Germany, Frankfurt Am Main, Germany. Electronic address: daniel.kramer@sanofi.com.
- 700 1_
- $a Link, Jenny $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: jenny.link@ki.se.
- 700 1_
- $a Ramanujam, Ryan $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden; KTH - Royal Institute of Technology, Stockholm, Sweden. Electronic address: Ryan.Ramanujam@ki.se.
- 700 1_
- $a Auer, Michael $u Innsbruck Medical University, Innsbruck, Austria. Electronic address: Michael.Auer@student.i-med.ac.at.
- 700 1_
- $a Buck, Dorothea $u Department of Neurology, Technische Universität München, Munich, Germany. Electronic address: dorothea.buck@tum.de.
- 700 1_
- $a Grummel, Verena $u Department of Neurology, Technische Universität München, Munich, Germany. Electronic address: v.grummel@tum.de.
- 700 1_
- $a Bertotti, Elisa $u Merck NBE Bioanalytics Ivrea, Colleretto Giacosa, Italy. Electronic address: elisa.bertotti@merckgroup.com.
- 700 1_
- $a Fissolo, Nicolas $u Hospital Universitari Vall d'Hebron, Centre d'Esclerosi Múltiple de Catalunya, Barcelona, Spain. Electronic address: nicolas.fissolo@vhir.org.
- 700 1_
- $a Oliver-Martos, Begoña $u Hospital Regional Universitario de Málaga, Instituto de investigación Biomédica de Málaga (IBIMA), Universidad de Málaga, Málaga, Spain.
- 700 1_
- $a Nytrova, Petra $u MS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. Electronic address: Petra.Nytrova@lf1.cuni.cz.
- 700 1_
- $a Khalil, Michael $u Department of Neurology, Medical University of Graz, Graz, Austria. Electronic address: michael.khalil@medunigraz.at.
- 700 1_
- $a Guger, Michael $u Clinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria. Electronic address: Michael.Guger@kepleruniklinikum.at.
- 700 1_
- $a Rathmaier, Sandra $u Clinic for Neurology 2, Kepler University Clinic, Med Campus III, Linz, Austria. Electronic address: Sandra.Rathmaier@kepleruniklinikum.at.
- 700 1_
- $a Sievers-Stober, Claudia $u Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: claudia.sievers-stober@unibas.ch.
- 700 1_
- $a Lindberg, Raija L P $u Departments of Biomedicine and Neurology, University Hospital Basel and University of Basel, Basel, Switzerland. Electronic address: Raija.Lindberg@unibas.ch.
- 700 1_
- $a Hässler, Signe $u CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France. Electronic address: signe.hassler@inserm.fr.
- 700 1_
- $a Bachelet, Delphine $u CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France. Electronic address: delphine.bachelet@inserm.fr.
- 700 1_
- $a Aktas, Orhan $u University of Düsseldorf, Medical Faculty, Department of Neurology, Düsseldorf, Germany. Electronic address: orhan.aktas@uni-duesseldorf.de.
- 700 1_
- $a Donnellan, Naoimh $u Ipsen Biopharm Ltd., Berkshire, United Kingdom.
- 700 1_
- $a Lawton, Andy $u GlaxoSmithKline R&D, Uxbridge, Middlesex, United Kingdom. Electronic address: andy.m.lawton@gsk.com.
- 700 1_
- $a Hemmer, Bernhard $u Department of Neurology, Technische Universität München, Munich, Germany; Munich Cluster for systems Neurology (SyNergy), Munich, Germany. Electronic address: hemmer@lrz.tu-muenchen.de.
- 700 1_
- $a Havrdova, Eva Kubala $u MS Center, Department of Neurology and Center Clinical Neuroscience, Charles University in Prague, 1st Faculty of Medicine and General University Hospital, Prague, Czech Republic. Electronic address: eva.havrdova@lf1.cuni.cz.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Pallardy, Marc $u INSERM UMR 996, Univ. Paris-Sud, Faculty of Pharmacy, Université Paris-Saclay, Châtenay-Malabry, France. Electronic address: marc.pallardy@u-psud.fr.
- 700 1_
- $a Spindeldreher, Sebastian $u Drug Metabolism Pharmacokinetics-Biologics, Novartis Institutes for Biomedical Research, Basel, Switzerland. Electronic address: sebastian.spindeldreher@novartis.com.
- 700 1_
- $a Broët, Philippe $u CESP, INSERM UMR 1018, Faculty of Medicine, Paris-Sud University, Paris-Saclay, University UVSQ, Villejuif, France; Assistance Publique - Hôpitaux de Paris, Hôpital Paul Brousse, Villejuif, France. Electronic address: philippe.broet@inserm.fr.
- 700 1_
- $a Deisenhammer, Florian $u Innsbruck Medical University, Innsbruck, Austria. Electronic address: Florian.Deisenhammer@tirol-kliniken.at.
- 700 1_
- $a Fogdell-Hahn, Anna $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Electronic address: Anna.Fogdell-Hahn@ki.se.
- 700 1_
- $a Sorensen, Per Soelberg $u Danish Multiple Sclerosis Center, Department of Neurology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. Electronic address: Per.Soelberg.Soerensen@regionh.dk.
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