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Comparative Analysis of B-Cell Receptor Repertoires Induced by Live Yellow Fever Vaccine in Young and Middle-Age Donors

AN. Davydov, AS. Obraztsova, MY. Lebedin, MA. Turchaninova, DB. Staroverov, EM. Merzlyak, GV. Sharonov, O. Kladova, M. Shugay, OV. Britanova, DM. Chudakov,

. 2018 ; 9 (-) : 2309. [pub] 20181009

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc19045172

Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In present study we employed 5'RACE UMI-based full length and nearly error-free immunoglobulin profiling to compare plasma cell antibody repertoires in young (19-26 years) and middle-age (45-58 years) individuals vaccinated with a live yellow fever vaccine, modeling a newly encountered pathogen. Our analysis has revealed age-related differences in the responding antibody repertoire ranging from distinct IGH CDR3 repertoire properties to differences in somatic hypermutation intensity and efficiency and antibody lineage tree structure. Overall, our findings suggest that younger individuals respond with a more diverse antibody repertoire and employ a more efficient somatic hypermutation process than elder individuals in response to a newly encountered pathogen.

Adaptive Immunity Group Central European Institute of Technology Brno Czechia

Adaptive Immunity Group Central European Institute of Technology Brno Czechia Center of Life Sciences Skolkovo Institute of Science and Technology Moscow Russia Genomics of Adaptive Immunity Department Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia Department of Molecular Technologies Pirogov Russian National Research Medical University Moscow Russia Laboratory of Genomics of Antitumor Adaptive Immunity Privolzhsky Research Medical University Nizhny Novgorod Russia

Center of Life Sciences Skolkovo Institute of Science and Technology Moscow Russia Genomics of Adaptive Immunity Department Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia Department of Molecular Technologies Pirogov Russian National Research Medical University Moscow Russia Laboratory of Genomics of Antitumor Adaptive Immunity Privolzhsky Research Medical University Nizhny Novgorod Russia

Department of Molecular Technologies Pirogov Russian National Research Medical University Moscow Russia

Faculty of Bioengineering and Bioinformatics Lomonosov Moscow State University Moscow Russia Center of Life Sciences Skolkovo Institute of Science and Technology Moscow Russia

Genomics of Adaptive Immunity Department Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia

Genomics of Adaptive Immunity Department Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia Department of Molecular Technologies Pirogov Russian National Research Medical University Moscow Russia

Genomics of Adaptive Immunity Department Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia Department of Molecular Technologies Pirogov Russian National Research Medical University Moscow Russia Laboratory of Genomics of Antitumor Adaptive Immunity Privolzhsky Research Medical University Nizhny Novgorod Russia

Genomics of Adaptive Immunity Department Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Moscow Russia Laboratory of Genomics of Antitumor Adaptive Immunity Privolzhsky Research Medical University Nizhny Novgorod Russia

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$a Age-related changes can significantly alter the state of adaptive immune system and often lead to attenuated response to novel pathogens and vaccination. In present study we employed 5'RACE UMI-based full length and nearly error-free immunoglobulin profiling to compare plasma cell antibody repertoires in young (19-26 years) and middle-age (45-58 years) individuals vaccinated with a live yellow fever vaccine, modeling a newly encountered pathogen. Our analysis has revealed age-related differences in the responding antibody repertoire ranging from distinct IGH CDR3 repertoire properties to differences in somatic hypermutation intensity and efficiency and antibody lineage tree structure. Overall, our findings suggest that younger individuals respond with a more diverse antibody repertoire and employ a more efficient somatic hypermutation process than elder individuals in response to a newly encountered pathogen.
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$a Obraztsova, Anna S $u Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia. Center of Life Sciences, Skolkovo Institute of Science and Technology, Moscow, Russia.
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