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Interleukin 6 and complement serum level study in Parkinson's disease

B. Veselý, M. Dufek, V. Thon, M. Brozman, S. Királová, T. Halászová, E. Koriťáková, I. Rektor,

. 2018 ; 125 (5) : 875-881. [pub] 20180212

Language English Country Austria

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc19045553

The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson's disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.

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$a Veselý, Branislav $u Department of Neurology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic. Central European Institute of Technology (CEITEC), Brain and Mind Research Programme, 625 00, Brno, Czech Republic.
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$a The objective of this study is to assess whether elevation of serum inflammatory markers levels may indicate the progression of clinical impairment in Parkinson's disease (PD) patients. In 47 PD patients, the serum levels of the C3 and C4 part of the complement and Interleukin-6 (IL-6) were measured. The results at baseline and after 2 years were correlated with scales measuring memory, depression, motor symptoms, and quality of life. Patients with higher levels of C3 and C4 at baseline had decreased quality of life, verbal ability, and memory. Patients with higher IL-6 at baseline showed worse depression scores at 2 years. Patients with persistently higher levels of C3 and C4 at 2 years had worse quality of life and memory ability. Uncorrected p values are reported due to the exploratory nature of the study. The results indicate an impact of inflammation on non-motor signs and quality of life in PD. The increase of levels of serum inflammatory biomarkers may indicate the progression of non-motor impairment in PD.
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$a Dufek, Michal $u Movement Disorders Center, First Department of Neurology, Masaryk University, St. Anne's University Hospital, Pekařská 664/53, 656 91, Brno, Czech Republic.
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$a Thon, Vojtech $u Department of Clinical Immunology and Allergy, Faculty of Medicine, Masaryk University, St. Anne's University Hospital, 656 91, Brno, Czech Republic.
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$a Brozman, Miroslav $u Department of Neurology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic.
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$a Királová, Silvia $u Department of Clinical Psychology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic.
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$a Halászová, Tatiana $u Department of Clinical Psychology, Faculty Hospital, Constantine the Philosopher University, Špitálska 6, 94901, Nitra, Slovak Republic.
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$a Koriťáková, Eva $u Institute of Biostatistics and Analyses, Faculty of Medicine, Masaryk University, Kamenice 123/3, 625 00, Brno, Czech Republic.
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$a Rektor, Ivan $u Movement Disorders Center, First Department of Neurology, Masaryk University, St. Anne's University Hospital, Pekařská 664/53, 656 91, Brno, Czech Republic. irektor@med.muni.cz. Central European Institute of Technology (CEITEC), Brain and Mind Research Programme, 625 00, Brno, Czech Republic. irektor@med.muni.cz.
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