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Twin loss in the uterus: neurodevelopmental impairment and reduced resilience?

Noémi Császár, István Bókkon

. 2019 ; 61 (4) : 217-226.

Language English Country Czech Republic

Persistent link   https://www.medvik.cz/link/bmc19050073

Spontaneous loss of a twin most often occurs in the first trimester. This phenomenon is called vanishing twin. Foetuses are especially vulnerable to various stress-related factors. As a result, twin loss in the uterus can produce deep and long-lasting consequences on mental health and may increase the risk of a variety of disease states in the surviving twin. In addition, twin loss may generate strong non-conscious stress that creates epigenetic alterations that impair the brain’s development endocrine and inflammatory substances produced by perturbed signalling pathways. These altered signalling pathways may generate lasting dysfunctions in various areas of the limbic system, predisposing the surviving twin to psychological and emotional problems later in life. We also hypothesise that specific cfDNA and other substances from the dead twin during its reabsorption may affect the surviving twin’s neurodevelopmental and emotional (e.g. resilience) development.

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Literatura

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