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Suicidal Leishmania

L. Podešvová, T. Leštinová, E. Horáková, J. Lukeš, P. Volf, V. Yurchenko,

. 2020 ; 9 (2) : . [pub] 20200125

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005302

Grantová podpora
19-15-00054 Russian Science Foundation
CZ LL1601 European Research Council - International
CZ.02.1.01/0.0/ 0.0/16_019/0000759 European Regional Development Fund
UNCE 20472 Grantová Agentura, Univerzita Karlova
SGS/PrF/2020 Ostravská Univerzita v Ostravě
"Přístroje IET" (CZ.1.05/2.1.00/19.0388) Ministerstvo Školství, Mládeže a Tělovýchovy

Leishmania are obligate intracellular parasites known to have developed successful ways of efficient immunity evasion. Because of this, leishmaniasis, a disease caused by these flagellated protists, is ranked as one of the most serious tropical infections worldwide. Neither prophylactic medication, nor vaccination has been developed thus far, even though the infection has usually led to strong and long-lasting immunity. In this paper, we describe a "suicidal" system established in Leishmaniamexicana, a human pathogen causing cutaneous leishmaniasis. This system is based on the expression and (de)stabilization of a basic phospholipase A2 toxin from the Bothropspauloensis snake venom, which leads to the inducible cell death of the parasites in vitro. Furthermore, the suicidal strain was highly attenuated during macrophage infection, regardless of the toxin stabilization. Such a deliberately weakened parasite could be used to vaccinate the host, as its viability is regulated by the toxin stabilization, causing a profoundly reduced pathogenesis.

Citace poskytuje Crossref.org

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