• Je něco špatně v tomto záznamu ?

Cyclic hydrostatic compress force regulates apoptosis of meniscus fibrochondrocytes via integrin alpha5beta1

Y. Zhang, F. Wang, L. Bao, J. Li, Z. Shi, J. Wang

. 2019 ; 68 (4) : 639-649. [pub] 20190606

Jazyk angličtina Země Česko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005481

Meniscus is a semilunar fibrocartilaginous tissue, serving important roles in load buffering, stability, lubrication, proprioception, and nutrition of the knee joint. The degeneration and damage of meniscus has been proved to be a risk factor of knee osteoarthritis. Mechanical stimulus is a critical factor of the development, maintenance and repair of the meniscus fibrochondrocytes. However, the mechanism of the mechano-transduction process remains elusive. Here we reported that cyclic hydrostatic compress force (CHCF) treatment promotes proliferation and inhibits apoptosis of the isolated primary meniscus fibrochondrocytes (PMFs), via upregulating the expression level of integrin ?5ß1. Consequently, increased phosphorylated-ERK1/2 and phosphorylated-PI3K, and decreased caspase-3 were detected. These effects of CHCF treatment can be abolished by integrin ?5ß1 inhibitor or specific siRNA transfection. These data indicate that CHCF regulates apoptosis of PMFs via integrin ?5ß1-FAK-PI3K/ERK pathway, which may be an important candidate approach during meniscus degeneration.

Citace poskytuje Crossref.org

Bibliografie atd.

Literatura

000      
00000naa a2200000 a 4500
001      
bmc20005481
003      
CZ-PrNML
005      
20200603084606.0
007      
ta
008      
200511s2019 xr ad f 000 0|eng||
009      
AR
024    7_
$a 10.33549/physiolres.934088 $2 doi
035    __
$a (PubMed)31177794
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xr
100    1_
$a Zhang, Y. $u Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
245    10
$a Cyclic hydrostatic compress force regulates apoptosis of meniscus fibrochondrocytes via integrin alpha5beta1 / $c Y. Zhang, F. Wang, L. Bao, J. Li, Z. Shi, J. Wang
504    __
$a Literatura
520    9_
$a Meniscus is a semilunar fibrocartilaginous tissue, serving important roles in load buffering, stability, lubrication, proprioception, and nutrition of the knee joint. The degeneration and damage of meniscus has been proved to be a risk factor of knee osteoarthritis. Mechanical stimulus is a critical factor of the development, maintenance and repair of the meniscus fibrochondrocytes. However, the mechanism of the mechano-transduction process remains elusive. Here we reported that cyclic hydrostatic compress force (CHCF) treatment promotes proliferation and inhibits apoptosis of the isolated primary meniscus fibrochondrocytes (PMFs), via upregulating the expression level of integrin ?5ß1. Consequently, increased phosphorylated-ERK1/2 and phosphorylated-PI3K, and decreased caspase-3 were detected. These effects of CHCF treatment can be abolished by integrin ?5ß1 inhibitor or specific siRNA transfection. These data indicate that CHCF regulates apoptosis of PMFs via integrin ?5ß1-FAK-PI3K/ERK pathway, which may be an important candidate approach during meniscus degeneration.
650    _2
$a zvířata $7 D000818
650    _2
$a apoptóza $x fyziologie $x účinky léků $7 D017209
650    _2
$a proliferace buněk $x fyziologie $7 D049109
650    _2
$a kultivované buňky $7 D002478
650    _2
$a chondrocyty $x metabolismus $x účinky léků $7 D019902
650    _2
$a pevnost v tlaku $x fyziologie $7 D019245
650    _2
$a fibroblasty $x metabolismus $x účinky léků $7 D005347
650    _2
$a hydrostatický tlak $7 D006874
650    _2
$a integrin alfa5beta1 $x antagonisté a inhibitory $x metabolismus $7 D039081
650    _2
$a buněčný převod mechanických signálů $x fyziologie $7 D040542
650    _2
$a meniskus $x cytologie $x metabolismus $7 D000072600
650    _2
$a malá interferující RNA $x aplikace a dávkování $7 D034741
650    _2
$a krysa rodu Rattus $7 D051381
650    _2
$a potkani Sprague-Dawley $7 D017207
655    _2
$a časopisecké články $7 D016428
700    1_
$a Wang, F. $u Department of Orthopedic Surgery, The First Hospital of Ka Shi, Kashi Xinjiang, China
700    1_
$a Bao, L. $u Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
700    1_
$a Li, J. $u Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
700    1_
$a Shi, Z. $u Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
700    1_
$a Wang, J. $u Department of Orthopedic Surgery, Nanfang Hospital, Southern Medical University, Guangzhou, China
773    0_
$w MED00003824 $t Physiological research $x 1802-9973 $g Roč. 68, č. 4 (2019), s. 639-649
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31177794 $y Pubmed
910    __
$a ABA008 $b A 4120 $c 266 $y p $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200601095921 $b ABA008
999    __
$a ok $b bmc $g 1530835 $s 1095536
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 68 $c 4 $d 639-649 $e 20190606 $i 1802-9973 $m Physiological research $n Physiol. Res. (Print) $x MED00003824
LZP    __
$b NLK118 $a Pubmed-20200511

Najít záznam

Citační ukazatele

Možnosti archivace