Detail
Článek
Článek online
FT
Medvik - BMČ
  • Je něco špatně v tomto záznamu ?

The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study

T. Olejar, D. Vetvicka, J. Boucek, M. Zabrodsky, J. Benes, M. Kabesova, P. Pouckova,

. 2020 ; 40 (1) : 349-356. [pub] -

Jazyk angličtina Země Řecko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20005598

Grantová podpora
NV16-28594A MZ0 CEP - Centrální evidence projektů

BACKGROUND/AIM: Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this receptor has also been confirmed in other tissues under pathological conditions including cancer. The aim of the presented pilot study was to evaluate the expression of FSHr in head and neck squamous cancer (HNSCC). PATIENTS AND METHODS: A total of 28 HNSCC patient samples were immunohistochemically analyzed for the presence of FSHr using a commercially available primary antibody. RESULTS: FSHr was detected not only in the tumor tissue, but also in the basal layer or dysplastic parts of squamous mucosa and also in fibroblasts surrounding the tumor tissue. CONCLUSION: FSHr is present on different benign or malignant mesenchymal and epithelial structures in HNSCC. A brief literature review revealed a wider role of FSHr in the development of neoplasia.

Citace poskytuje Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20005598
003      
CZ-PrNML
005      
20200526134346.0
007      
ta
008      
200511s2020 gr f 000 0|eng||
009      
AR
024    7_
$a 10.21873/anticanres.13959 $2 doi
035    __
$a (PubMed)31892586
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a gr
100    1_
$a Olejar, Tomas $u Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic. Institute of Pathology and Molecular Medicine, Thomayer Memorial Hospital in Prague and 3rd Faculty of Medicine, Charles University, Prague, Czech Republic.
245    14
$a The FSHR Expression in Head and Neck Squamous Cell Cancer. A Pilot Immunohistochemical Study / $c T. Olejar, D. Vetvicka, J. Boucek, M. Zabrodsky, J. Benes, M. Kabesova, P. Pouckova,
520    9_
$a BACKGROUND/AIM: Follicle-stimulating hormone receptor (FSHr), expressed on endothelial cells of vessels in different malignant tumors, has been recently investigated as a potential pan-receptor of cancer treatment. However, the expression of this receptor has also been confirmed in other tissues under pathological conditions including cancer. The aim of the presented pilot study was to evaluate the expression of FSHr in head and neck squamous cancer (HNSCC). PATIENTS AND METHODS: A total of 28 HNSCC patient samples were immunohistochemically analyzed for the presence of FSHr using a commercially available primary antibody. RESULTS: FSHr was detected not only in the tumor tissue, but also in the basal layer or dysplastic parts of squamous mucosa and also in fibroblasts surrounding the tumor tissue. CONCLUSION: FSHr is present on different benign or malignant mesenchymal and epithelial structures in HNSCC. A brief literature review revealed a wider role of FSHr in the development of neoplasia.
650    _2
$a zvířata $7 D000818
650    _2
$a nádorové buněčné linie $7 D045744
650    _2
$a ženské pohlaví $7 D005260
650    _2
$a lidé $7 D006801
650    _2
$a imunohistochemie $7 D007150
650    _2
$a myši $7 D051379
650    _2
$a pilotní projekty $7 D010865
650    _2
$a receptory FSH $x metabolismus $7 D011962
650    _2
$a dlaždicobuněčné karcinomy hlavy a krku $x metabolismus $7 D000077195
655    _2
$a časopisecké články $7 D016428
700    1_
$a Vetvicka, David $u Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic david.vetvicka@lf1.cuni.cz.
700    1_
$a Boucek, Jan $u Department of Otorhinolaryngology Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
700    1_
$a Zabrodsky, Michal $u Department of Otorhinolaryngology Head and Neck Surgery, First Faculty of Medicine, Charles University and University Hospital Motol, Prague, Czech Republic.
700    1_
$a Benes, Jiri $u Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
700    1_
$a Kabesova, Martina $u Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
700    1_
$a Pouckova, Pavla $u Institute of Biophysics and Informatics, 1st Faculty of Medicine, Charles University, Prague, Czech Republic.
773    0_
$w MED00000478 $t Anticancer research $x 1791-7530 $g Roč. 40, č. 1 (2020), s. 349-356
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31892586 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20200511 $b ABA008
991    __
$a 20200526134342 $b ABA008
999    __
$a ok $b bmc $g 1524456 $s 1095654
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2020 $b 40 $c 1 $d 349-356 $e - $i 1791-7530 $m Anticancer research $n Anticancer Res $x MED00000478
GRA    __
$a NV16-28594A $p MZ0
LZP    __
$a Pubmed-20200511

Najít záznam

Citační ukazatele

Pouze přihlášení uživatelé

Možnosti archivace