-
Je něco špatně v tomto záznamu ?
Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng/L level caused intersex
P. Šauer, J. Tumová, C. Steinbach, O. Golovko, H. Komen, E. Maillot-Maréchal, J. Máchová, R. Grabic, S. Aït-Aïssa, H. Kocour Kroupová,
Jazyk angličtina Země Nizozemsko
Typ dokumentu časopisecké články
- MeSH
- androsteny toxicita MeSH
- chemické látky znečišťující vodu toxicita MeSH
- endokrinní disruptory toxicita MeSH
- gonády účinky léků MeSH
- hepatopankreas účinky léků MeSH
- hypofýza účinky léků MeSH
- hypothalamus účinky léků MeSH
- kapři růst a vývoj MeSH
- norpregneny toxicita MeSH
- sexuální diferenciace účinky léků genetika MeSH
- vývojová regulace genové exprese účinky léků MeSH
- vztah mezi dávkou a účinkem léčiva MeSH
- zvířata MeSH
- Check Tag
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
Synthetic progestins are emerging contaminants of the aquatic environment with endocrine disrupting potential. The main aim of the present study was to investigate the effects of the synthetic progestins gestodene, and drospirenone on sex differentiation in common carp (Cyprinus carpio) by histological analysis. To gain insights into the mechanisms behind the observations from the in vivo experiment on sex differentiation, we analyzed expression of genes involved in hypothalamus-pituitary-gonad (HPG) and hypothalamus-pituitary-thyroid (HPT) axes, histology of hepatopancreas, and in vitro bioassays. Carp were continuously exposed to concentrations of 2 ng/L of single progestins (gestodene or drospirenone) or to their mixture at concentration 2 ng/L of each. The exposure started 24 h after fertilization of eggs and concluded 160 days post-hatching. Our results showed that exposure of common carp to a binary mixture of drospirenone and gestodene caused increased incidence of intersex (32%) when compared to clean water and solvent control groups (both 3%). Intersex most probably was induced by a combination of multiple modes of action of the studied substances, namely anti-gonadotropic activity, interference with androgen receptor, and potentially also with HPT axis or estrogen receptor.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20005711
- 003
- CZ-PrNML
- 005
- 20200519205146.0
- 007
- ta
- 008
- 200511s2020 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.ecoenv.2019.109912 $2 doi
- 035 __
- $a (PubMed)31706240
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Šauer, Pavel $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic. Electronic address: psauer@frov.jcu.cz.
- 245 10
- $a Chronic simultaneous exposure of common carp (Cyprinus carpio) from embryonic to juvenile stage to drospirenone and gestodene at low ng/L level caused intersex / $c P. Šauer, J. Tumová, C. Steinbach, O. Golovko, H. Komen, E. Maillot-Maréchal, J. Máchová, R. Grabic, S. Aït-Aïssa, H. Kocour Kroupová,
- 520 9_
- $a Synthetic progestins are emerging contaminants of the aquatic environment with endocrine disrupting potential. The main aim of the present study was to investigate the effects of the synthetic progestins gestodene, and drospirenone on sex differentiation in common carp (Cyprinus carpio) by histological analysis. To gain insights into the mechanisms behind the observations from the in vivo experiment on sex differentiation, we analyzed expression of genes involved in hypothalamus-pituitary-gonad (HPG) and hypothalamus-pituitary-thyroid (HPT) axes, histology of hepatopancreas, and in vitro bioassays. Carp were continuously exposed to concentrations of 2 ng/L of single progestins (gestodene or drospirenone) or to their mixture at concentration 2 ng/L of each. The exposure started 24 h after fertilization of eggs and concluded 160 days post-hatching. Our results showed that exposure of common carp to a binary mixture of drospirenone and gestodene caused increased incidence of intersex (32%) when compared to clean water and solvent control groups (both 3%). Intersex most probably was induced by a combination of multiple modes of action of the studied substances, namely anti-gonadotropic activity, interference with androgen receptor, and potentially also with HPT axis or estrogen receptor.
- 650 _2
- $a androsteny $x toxicita $7 D000736
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a kapři $x růst a vývoj $7 D002347
- 650 _2
- $a vztah mezi dávkou a účinkem léčiva $7 D004305
- 650 _2
- $a endokrinní disruptory $x toxicita $7 D052244
- 650 _2
- $a vývojová regulace genové exprese $x účinky léků $7 D018507
- 650 _2
- $a gonády $x účinky léků $7 D006066
- 650 _2
- $a hepatopankreas $x účinky léků $7 D043143
- 650 _2
- $a hypothalamus $x účinky léků $7 D007031
- 650 _2
- $a norpregneny $x toxicita $7 D009652
- 650 _2
- $a hypofýza $x účinky léků $7 D010902
- 650 _2
- $a sexuální diferenciace $x účinky léků $x genetika $7 D012733
- 650 _2
- $a chemické látky znečišťující vodu $x toxicita $7 D014874
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Tumová, Jitka $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic.
- 700 1_
- $a Steinbach, Christoph $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic.
- 700 1_
- $a Golovko, Oksana $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic; Department of Aquatic Sciences and Assessment, Swedish University of Agricultural Sciences (SLU), Box 7050, SE-750 07, Uppsala, Sweden.
- 700 1_
- $a Komen, Hans $u Wageningen University, Animal Breeding and Genomics Centre, Wageningen, the Netherlands.
- 700 1_
- $a Maillot-Maréchal, Emmanuelle $u Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, UMR-I 02 SEBIO, Verneuil-en-Halatte, France.
- 700 1_
- $a Máchová, Jana $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic.
- 700 1_
- $a Grabic, Roman $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic.
- 700 1_
- $a Aït-Aïssa, Selim $u Institut National de l'Environnement Industriel et des Risques (INERIS), Unité d'Ecotoxicologie in vitro et in vivo, UMR-I 02 SEBIO, Verneuil-en-Halatte, France.
- 700 1_
- $a Kocour Kroupová, Hana $u University of South Bohemia in České Budějovice, Faculty of Fisheries and Protection of Waters, Vodňany, Czech Republic. Electronic address: kroupova@frov.jcu.cz.
- 773 0_
- $w MED00001478 $t Ecotoxicology and environmental safety $x 1090-2414 $g Roč. 188, č. - (2020), s. 109912
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31706240 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20200519205143 $b ABA008
- 999 __
- $a ok $b bmc $g 1524569 $s 1095767
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 188 $c - $d 109912 $e 20191106 $i 1090-2414 $m Ecotoxicology and environmental safety $n Ecotoxicol Environ Safety $x MED00001478
- LZP __
- $a Pubmed-20200511
