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Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa
HJ. Watson, Z. Yilmaz, LM. Thornton, C. Hübel, JRI. Coleman, HA. Gaspar, J. Bryois, A. Hinney, VM. Leppä, M. Mattheisen, SE. Medland, S. Ripke, S. Yao, P. Giusti-Rodríguez, Anorexia Nervosa Genetics Initiative, KB. Hanscombe, KL. Purves, Eating...
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Perzistentní odkaz
https://www.medvik.cz/link/bmc20006150
Grantová podpora
K01 AA025113
NIAAA NIH HHS - United States
U01 MH109536
NIMH NIH HHS - United States
K01 MH109772
NIMH NIH HHS - United States
U01 HG006830
NHGRI NIH HHS - United States
K01 MH109782
NIMH NIH HHS - United States
K01 MH106675
NIMH NIH HHS - United States
R01 MH092793
NIMH NIH HHS - United States
U01 MH109528
NIMH NIH HHS - United States
R21 MH115397
NIMH NIH HHS - United States
Online
Plný text
NLK
ProQuest Central
od 2000-01-01 do Před 1 rokem
Health & Medicine (ProQuest)
od 2000-01-01 do Před 1 rokem
Public Health Database (ProQuest)
od 2000-01-01 do Před 1 rokem
- MeSH
- celogenomová asociační studie * MeSH
- dospělí MeSH
- duševní poruchy komplikace genetika MeSH
- fenotyp MeSH
- genetická predispozice k nemoci * MeSH
- genomika metody MeSH
- index tělesné hmotnosti MeSH
- lidé MeSH
- lokus kvantitativního znaku * MeSH
- mentální anorexie etiologie genetika patologie MeSH
- metabolické nemoci komplikace genetika MeSH
- prognóza MeSH
- studie případů a kontrol MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
American School of Professional Psychology Argosy University Northern Virginia Arlington VA USA
Biological Psychiatry Laboratory McLean Hospital Harvard Medical School Boston MA USA
BioRealm LLC Walnut CA USA Oregon Research Institute Eugene OR USA
Biostatistics and Computational Biology Unit University of Otago Christchurch New Zealand
Brain Sciences Department Stremble Ventures Limassol Cyprus
Center for Applied Genomics Children's Hospital of Philadelphia Philadelphia PA USA
Center for Eating Disorders Rintveld Altrecht Mental Health Institute Zeist the Netherlands
Christchurch Health and Development Study University of Otago Christchurch New Zealand
Clinical Genetics Unit Department of Woman and Child Health University of Padova Padova Italy
College of Nursing Seattle University Seattle WA USA
Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Biomedical Data Science Leiden University Medical Centre Leiden the Netherlands
Department of Cancer Epidemiology and Genetics Masaryk Memorial Cancer Institute Brno Czech Republic
Department of Child and Adolescent Psychiatry Klinikum Frankfurt Oder Frankfurt Germany
Department of Child and Adolescent Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Clinical Medicine University of Copenhagen Copenhagen Denmark
Department of Environmental Epidemiology Nofer Institute of Occupational Medicine Lodz Poland
Department of Genetics and Genomic Biology The Hospital for Sick Children Toronto Ontario Canada
Department of Genetics University of North Carolina at Chapel Hill Chapel Hill NC USA
Department of Medical and Molecular Genetics King's College London Guy's Hospital London UK
Department of Medical Epidemiology and Biostatistics Karolinska Institutet Stockholm Sweden
Department of Mental Disorders Norwegian Institute of Public Health Oslo Norway
Department of Neurosciences Padua Neuroscience Center University of Padova Padova Italy
Department of Neurosciences University of Padova Padova Italy
Department of Nutrition and Dietetics Harokopio University Athens Greece
Department of Paediatric Laboratory Medicine The Hospital for Sick Children Toronto Ontario Canada
Department of Pathology and Biomedical Science University of Otago Christchurch New Zealand
Department of Psychiatric Genetics Poznan University of Medical Sciences Poznan Poland
Department of Psychiatry 1st Faculty of Medicine Charles University Prague Czech Republic
Department of Psychiatry and Behavioral Sciences Stanford University Stanford CA USA
Department of Psychiatry and Psychotherapy Ludwig Maximilians University Munich Germany
Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria
Department of Psychiatry Athens University Medical School Athens University Athens Greece
Department of Psychiatry Neurobiology Pharmacology and Biotechnologies University of Pisa Pisa Italy
Department of Psychiatry Poznan University of Medical Sciences Poznan Poland
Department of Psychiatry Seoul Paik Hospital Inje University Seoul Korea
Department of Psychiatry University of California San Diego San Diego CA USA
Department of Psychiatry University of Campania Luigi Vanvitelli Naples Italy
Department of Psychiatry University of Minnesota Minneapolis MN USA
Department of Psychiatry University of North Carolina at Chapel Hill Chapel Hill NC USA
Department of Psychiatry Weill Cornell Medical College New York NY USA
Department of Psychology Michigan State University East Lansing MI USA
Department of Psychology Virginia Commonwealth University Richmond VA USA
Department of Psychosomatic Medicine and Psychotherapy Hannover Medical School Hannover Germany
Department of Public Health University of Helsinki Helsinki Finland
Department of Surgery Faculty of Medicine University of Toronto Toronto Ontario Canada
Eating Disorders Unit Parklandklinik Bad Wildungen Germany
Eating Recovery Center Denver CO USA
Estonian Genome Center University of Tartu Tartu Estonia
Faculty of Health Sciences Palacky University Olomouc Czech Republic
INSERM 1266 Institute of Psychiatry and Neuroscience of Paris Paris France
Institute for Molecular Bioscience University of Queensland Brisbane Queensland Australia
Institute of Applied Health Sciences University of Aberdeen Aberdeen UK
Institute of Environmental Medicine Karolinska Institutet Stockholm Sweden
Institute of Medical Genetics and Pathology University Hospital Basel Basel Switzerland
Institute of Medical Statistics Computer and Data Sciences Jena University Hospital Jena Germany
J Craig Venter Institute La Jolla CA USA
Kartini Clinic Portland OR USA
L'institut du thorax INSERM CNRS UNIV Nantes CHU Nantes Nantes France
QIMR Berghofer Medical Research Institute Brisbane Queensland Australia
Rheumatology Research Group Vall d'Hebron Research Institute Barcelona Spain
School of Psychology Flinders University Adelaide South Australia Australia
The Center for Eating Disorders at Sheppard Pratt Baltimore MD USA
Citace poskytuje Crossref.org
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- $a Watson, Hunna J $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. School of Psychology, Curtin University, Perth, Western Australia, Australia. School of Paediatrics and Child Health, University of Western Australia, Perth, Western Australia, Australia.
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- $a Genome-wide association study identifies eight risk loci and implicates metabo-psychiatric origins for anorexia nervosa / $c HJ. Watson, Z. Yilmaz, LM. Thornton, C. Hübel, JRI. Coleman, HA. Gaspar, J. Bryois, A. Hinney, VM. Leppä, M. Mattheisen, SE. Medland, S. Ripke, S. Yao, P. Giusti-Rodríguez, Anorexia Nervosa Genetics Initiative, KB. Hanscombe, KL. Purves, Eating Disorders Working Group of the Psychiatric Genomics Consortium, RAH. Adan, L. Alfredsson, T. Ando, OA. Andreassen, JH. Baker, WH. Berrettini, I. Boehm, C. Boni, VB. Perica, K. Buehren, R. Burghardt, M. Cassina, S. Cichon, M. Clementi, RD. Cone, P. Courtet, S. Crow, JJ. Crowley, UN. Danner, OSP. Davis, M. de Zwaan, G. Dedoussis, D. Degortes, JE. DeSocio, DM. Dick, D. Dikeos, C. Dina, M. Dmitrzak-Weglarz, E. Docampo, LE. Duncan, K. Egberts, S. Ehrlich, G. Escaramís, T. Esko, X. Estivill, A. Farmer, A. Favaro, F. Fernández-Aranda, MM. Fichter, K. Fischer, M. Föcker, L. Foretova, AJ. Forstner, M. Forzan, CS. Franklin, S. Gallinger, I. Giegling, J. Giuranna, F. Gonidakis, P. Gorwood, MG. Mayora, S. Guillaume, Y. Guo, H. Hakonarson, K. Hatzikotoulas, J. Hauser, J. Hebebrand, SG. Helder, S. Herms, B. Herpertz-Dahlmann, W. Herzog, LM. Huckins, JI. Hudson, H. Imgart, H. Inoko, V. Janout, S. Jiménez-Murcia, A. Julià, G. Kalsi, D. Kaminská, J. Kaprio, L. Karhunen, A. Karwautz, MJH. Kas, JL. Kennedy, A. Keski-Rahkonen, K. Kiezebrink, YR. Kim, L. Klareskog, KL. Klump, GPS. Knudsen, MC. La Via, S. Le Hellard, RD. Levitan, D. Li, L. Lilenfeld, BD. Lin, J. Lissowska, J. Luykx, PJ. Magistretti, M. Maj, K. Mannik, S. Marsal, CR. Marshall, M. Mattingsdal, S. McDevitt, P. McGuffin, A. Metspalu, I. Meulenbelt, N. Micali, K. Mitchell, AM. Monteleone, P. Monteleone, MA. Munn-Chernoff, B. Nacmias, M. Navratilova, I. Ntalla, JK. O'Toole, RA. Ophoff, L. Padyukov, A. Palotie, J. Pantel, H. Papezova, D. Pinto, R. Rabionet, A. Raevuori, N. Ramoz, T. Reichborn-Kjennerud, V. Ricca, S. Ripatti, F. Ritschel, M. Roberts, A. Rotondo, D. Rujescu, F. Rybakowski, P. Santonastaso, A. Scherag, SW. Scherer, U. Schmidt, NJ. Schork, A. Schosser, J. Seitz, L. Slachtova, PE. Slagboom, MCT. Slof-Op 't Landt, A. Slopien, S. Sorbi, B. Świątkowska, JP. Szatkiewicz, I. Tachmazidou, E. Tenconi, A. Tortorella, F. Tozzi, J. Treasure, A. Tsitsika, M. Tyszkiewicz-Nwafor, K. Tziouvas, AA. van Elburg, EF. van Furth, G. Wagner, E. Walton, E. Widen, E. Zeggini, S. Zerwas, S. Zipfel, AW. Bergen, JM. Boden, H. Brandt, S. Crawford, KA. Halmi, LJ. Horwood, C. Johnson, AS. Kaplan, WH. Kaye, JE. Mitchell, CM. Olsen, JF. Pearson, NL. Pedersen, M. Strober, T. Werge, DC. Whiteman, DB. Woodside, GD. Stuber, S. Gordon, J. Grove, AK. Henders, A. Juréus, KM. Kirk, JT. Larsen, R. Parker, L. Petersen, J. Jordan, M. Kennedy, GW. Montgomery, TD. Wade, A. Birgegård, P. Lichtenstein, C. Norring, M. Landén, NG. Martin, PB. Mortensen, PF. Sullivan, G. Breen, CM. Bulik,
- 520 9_
- $a Characterized primarily by a low body-mass index, anorexia nervosa is a complex and serious illness1, affecting 0.9-4% of women and 0.3% of men2-4, with twin-based heritability estimates of 50-60%5. Mortality rates are higher than those in other psychiatric disorders6, and outcomes are unacceptably poor7. Here we combine data from the Anorexia Nervosa Genetics Initiative (ANGI)8,9 and the Eating Disorders Working Group of the Psychiatric Genomics Consortium (PGC-ED) and conduct a genome-wide association study of 16,992 cases of anorexia nervosa and 55,525 controls, identifying eight significant loci. The genetic architecture of anorexia nervosa mirrors its clinical presentation, showing significant genetic correlations with psychiatric disorders, physical activity, and metabolic (including glycemic), lipid and anthropometric traits, independent of the effects of common variants associated with body-mass index. These results further encourage a reconceptualization of anorexia nervosa as a metabo-psychiatric disorder. Elucidating the metabolic component is a critical direction for future research, and paying attention to both psychiatric and metabolic components may be key to improving outcomes.
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- $a Yilmaz, Zeynep $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
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- 700 1_
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- 700 1_
- $a Coleman, Jonathan R I $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK. National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
- 700 1_
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- 700 1_
- $a Bryois, Julien $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
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- 700 1_
- $a Leppä, Virpi M $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Mattheisen, Manuel $u Department of Biomedicine, Aarhus University, Aarhus, Denmark. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden. Department of Psychiatry, Psychosomatics and Psychotherapy, University of Würzburg, Würzburg, Germany.
- 700 1_
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- 700 1_
- $a Ripke, Stephan $u Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA. Stanley Center for Psychiatric Research, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Department of Psychiatry and Psychotherapy, Charité - Universitätsmedizin, Berlin, Germany.
- 700 1_
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- 700 1_
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- 700 1_
- $a Hanscombe, Ken B $u Department of Medical and Molecular Genetics, King's College London, Guy's Hospital, London, UK.
- 700 1_
- $a Purves, Kirstin L $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
- 700 1_
- $a Adan, Roger A H $u Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands. Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands. Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
- 700 1_
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- 700 1_
- $a Ando, Tetsuya $u Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan.
- 700 1_
- $a Andreassen, Ole A $u NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.
- 700 1_
- $a Baker, Jessica H $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Berrettini, Wade H $u Department of Psychiatry, Center for Neurobiology and Behavior, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
- $a Boehm, Ilka $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
- 700 1_
- $a Boni, Claudette $u INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
- 700 1_
- $a Perica, Vesna Boraska $u Wellcome Sanger Institute, Hinxton, UK. Department of Medical Biology, School of Medicine, University of Split, Split, Croatia.
- 700 1_
- $a Buehren, Katharina $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Crowley, James J $u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Danner, Unna N $u Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands.
- 700 1_
- $a Davis, Oliver S P $u MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK. School of Social and Community Medicine, University of Bristol, Bristol, UK.
- 700 1_
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- 700 1_
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- 700 1_
- $a Degortes, Daniela $u Department of Neurosciences, University of Padova, Padova, Italy.
- 700 1_
- $a DeSocio, Janiece E $u College of Nursing, Seattle University, Seattle, WA, USA.
- 700 1_
- $a Dick, Danielle M $u Department of Psychology, Virginia Commonwealth University, Richmond, VA, USA.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Esko, Tõnu $u Estonian Genome Center, University of Tartu, Tartu, Estonia. Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA.
- 700 1_
- $a Estivill, Xavier $u Barcelona Institute of Science and Technology, Barcelona, Spain. Universitat Pompeu Fabra, Barcelona, Spain. Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain. Genomics and Disease, Bioinformatics and Genomics Programme, Centre for Genomic Regulation, Barcelona, Spain.
- 700 1_
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- 700 1_
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- 700 1_
- $a Fernández-Aranda, Fernando $u Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain. Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Fichter, Manfred M $u Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany. Schön Klinik Roseneck affiliated with the Medical Faculty of the University of Munich (LMU), Munich, Germany.
- 700 1_
- $a Fischer, Krista $u Estonian Genome Center, University of Tartu, Tartu, Estonia.
- 700 1_
- $a Föcker, Manuel $u Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
- 700 1_
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- 700 1_
- $a Forstner, Andreas J $u Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. Institute of Human Genetics, University of Bonn, School of Medicine & University Hospital Bonn, Bonn, Germany. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. Department of Psychiatry (UPK), University of Basel, Basel, Switzerland. Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Guillaume, Sébastien $u Department of Emergency Psychiatry and Post-Acute Care, CHRU Montpellier, University of Montpellier, Montpellier, France.
- 700 1_
- $a Guo, Yiran $u Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
- 700 1_
- $a Hakonarson, Hakon $u Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA. Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
- 700 1_
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- 700 1_
- $a Hauser, Joanna $u Department of Adult Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Hebebrand, Johannes $u Department of Child and Adolescent Psychiatry, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
- 700 1_
- $a Helder, Sietske G $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK. Zorg op Orde, Leidschendam, the Netherlands.
- 700 1_
- $a Herms, Stefan $u Institute of Medical Genetics and Pathology, University Hospital Basel, Basel, Switzerland. Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. Department of Biomedicine, University of Basel, Basel, Switzerland.
- 700 1_
- $a Herpertz-Dahlmann, Beate $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
- 700 1_
- $a Herzog, Wolfgang $u Department of General Internal Medicine and Psychosomatics, Heidelberg University Hospital, Heidelberg University, Heidelberg, Germany.
- 700 1_
- $a Huckins, Laura M $u Wellcome Sanger Institute, Hinxton, UK. Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 700 1_
- $a Hudson, James I $u Biological Psychiatry Laboratory, McLean Hospital/Harvard Medical School, Boston, MA, USA.
- 700 1_
- $a Imgart, Hartmut $u Eating Disorders Unit, Parklandklinik, Bad Wildungen, Germany.
- 700 1_
- $a Inoko, Hidetoshi $u Department of Molecular Life Science, Division of Basic Medical Science and Molecular Medicine, School of Medicine, Tokai University, Isehara, Japan.
- 700 1_
- $a Janout, Vladimir $u Faculty of Health Sciences, Palacky University, Olomouc, Czech Republic.
- 700 1_
- $a Jiménez-Murcia, Susana $u Department of Psychiatry, University Hospital of Bellvitge -IDIBELL and CIBERobn, Barcelona, Spain. Department of Clinical Sciences, School of Medicine, University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Julià, Antonio $u Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
- 700 1_
- $a Kalsi, Gursharan $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
- 700 1_
- $a Kaminská, Deborah $u Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Kaprio, Jaakko $u Department of Public Health, University of Helsinki, Helsinki, Finland. Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Karhunen, Leila $u Institute of Public Health and Clinical Nutrition, Department of Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
- 700 1_
- $a Karwautz, Andreas $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Kas, Martien J H $u Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands. Groningen Institute for Evolutionary Life Sciences, University of Groningen, Groningen, the Netherlands.
- 700 1_
- $a Kennedy, James L $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Keski-Rahkonen, Anna $u Department of Public Health, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Kiezebrink, Kirsty $u Institute of Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
- 700 1_
- $a Kim, Youl-Ri $u Department of Psychiatry, Seoul Paik Hospital, Inje University, Seoul, Korea.
- 700 1_
- $a Klareskog, Lars $u Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Klump, Kelly L $u Department of Psychology, Michigan State University, East Lansing, MI, USA.
- 700 1_
- $a Knudsen, Gun Peggy S $u Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway.
- 700 1_
- $a La Via, Maria C $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Le Hellard, Stephanie $u Department of Clinical Science, K.G. Jebsen Centre for Psychosis Research, Norwegian Centre for Mental Disorders Research (NORMENT), University of Bergen, Bergen, Norway. Dr. Einar Martens Research Group for Biological Psychiatry, Center for Medical Genetics and Molecular Medicine, Haukeland University Hospital, Bergen, Norway. Department of Clinical Medicine, Laboratory Building, Haukeland University Hospital, Bergen, Norway.
- 700 1_
- $a Levitan, Robert D $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Li, Dong $u Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
- 700 1_
- $a Lilenfeld, Lisa $u American School of Professional Psychology, Argosy University, Northern Virginia, Arlington, VA, USA.
- 700 1_
- $a Lin, Bochao Danae $u Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
- 700 1_
- $a Lissowska, Jolanta $u Department of Cancer Epidemiology and Prevention, M Skłodowska-Curie Cancer Center - Oncology Center, Warsaw, Poland.
- 700 1_
- $a Luykx, Jurjen $u Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands.
- 700 1_
- $a Magistretti, Pierre J $u BESE Division, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia. Department of Psychiatry, University of Lausanne-University Hospital of Lausanne (UNIL-CHUV), Lausanne, Switzerland.
- 700 1_
- $a Maj, Mario $u Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- 700 1_
- $a Mannik, Katrin $u Estonian Genome Center, University of Tartu, Tartu, Estonia. Center for Integrative Genomics, University of Lausanne, Lausanne, Switzerland.
- 700 1_
- $a Marsal, Sara $u Rheumatology Research Group, Vall d'Hebron Research Institute, Barcelona, Spain.
- 700 1_
- $a Marshall, Christian R $u Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 700 1_
- $a Mattingsdal, Morten $u NORMENT KG Jebsen Centre, Division of Mental Health and Addiction, University of Oslo, Oslo University Hospital, Oslo, Norway.
- 700 1_
- $a McDevitt, Sara $u Department of Psychiatry, University College Cork, Cork, Ireland. HSE National Clinical Programme for Eating Disorders, Cork, Ireland.
- 700 1_
- $a McGuffin, Peter $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK.
- 700 1_
- $a Metspalu, Andres $u Estonian Genome Center, University of Tartu, Tartu, Estonia. Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia.
- 700 1_
- $a Meulenbelt, Ingrid $u Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a Micali, Nadia $u Department of Psychiatry, Faculty of Medicine, University of Geneva, Geneva, Switzerland. Division of Child and Adolescent Psychiatry, Geneva University Hospital, Geneva, Switzerland. Great Ormond Street Institute of Child Health, University College London, London, UK.
- 700 1_
- $a Mitchell, Karen $u National Center for PTSD, VA Boston Healthcare System, Department of Psychiatry, Boston University School of Medicine, Boston, MA, USA.
- 700 1_
- $a Monteleone, Alessio Maria $u Department of Psychiatry, University of Campania "Luigi Vanvitelli", Naples, Italy.
- 700 1_
- $a Monteleone, Palmiero $u Department of Medicine, Surgery and Dentistry "Scuola Medica Salernitana", University of Salerno, Salerno, Italy.
- 700 1_
- $a Munn-Chernoff, Melissa A $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Nacmias, Benedetta $u Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy.
- 700 1_
- $a Navratilova, Marie $u Department of Cancer, Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Ntalla, Ioanna $u Department of Nutrition and Dietetics, Harokopio University, Athens, Greece.
- 700 1_
- $a O'Toole, Julie K $u Kartini Clinic, Portland, OR, USA.
- 700 1_
- $a Ophoff, Roel A $u Brain Center Rudolf Magnus, Department of Translational Neuroscience, University Medical Center Utrecht, Utrecht, the Netherlands. Center for Neurobehavioral Genetics, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA.
- 700 1_
- $a Padyukov, Leonid $u Rheumatology Unit, Department of Medicine, Center for Molecular Medicine, Karolinska Institutet and Karolinska University Hospital, Stockholm, Sweden.
- 700 1_
- $a Palotie, Aarno $u Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland. Center for Human Genome Research at the Massachusetts General Hospital, Boston, MA, USA.
- 700 1_
- $a Pantel, Jacques $u INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
- 700 1_
- $a Papezova, Hana $u Department of Psychiatry, First Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Pinto, Dalila $u Department of Psychiatry, and Genetics and Genomics Sciences, Division of Psychiatric Genomics, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
- 700 1_
- $a Rabionet, Raquel $u Saint Joan de Déu Research Institute, Saint Joan de Déu Barcelona Children's Hospital, Barcelona, Spain. Institute of Biomedicine (IBUB), University of Barcelona, Barcelona, Spain. Department of Genetics, Microbiology and Statistics, University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Raevuori, Anu $u Department of Public Health, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Ramoz, Nicolas $u INSERM 1266, Institute of Psychiatry and Neuroscience of Paris, Paris, France.
- 700 1_
- $a Reichborn-Kjennerud, Ted $u Department of Mental Disorders, Norwegian Institute of Public Health, Oslo, Norway. Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
- 700 1_
- $a Ricca, Valdo $u Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy. Department of Health Science, University of Florence, Florence, Italy.
- 700 1_
- $a Ripatti, Samuli $u Program in Medical and Population Genetics, Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, MA, USA. Department of Public Health, University of Helsinki, Helsinki, Finland. Institute for Molecular Medicine Finland (FIMM), HiLIFE Unit, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Ritschel, Franziska $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany. Eating Disorders Research and Treatment Center, Department of Child and Adolescent Psychiatry, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
- 700 1_
- $a Roberts, Marion $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK. Department of Psychological Medicine, University of Otago, Christchurch, New Zealand. Faculty of Medicine & Health Sciences, University of Aukland, Aukland, New Zealand.
- 700 1_
- $a Rotondo, Alessandro $u Department of Psychiatry, Neurobiology, Pharmacology, and Biotechnologies, University of Pisa, Pisa, Italy.
- 700 1_
- $a Rujescu, Dan $u Department of Psychiatry and Psychotherapy, Ludwig-Maximilians-University (LMU), Munich, Germany. Department of Psychiatry, Psychotherapy and Psychosomatics, Martin Luther University of Halle-Wittenberg, Halle, Germany.
- 700 1_
- $a Rybakowski, Filip $u Department of Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Santonastaso, Paolo $u Department of Neurosciences, Padua Neuroscience Center, University of Padova, Padova, Italy.
- 700 1_
- $a Scherag, André $u Institute of Medical Statistics, Computer and Data Sciences, Jena University Hospital, Jena, Germany.
- 700 1_
- $a Scherer, Stephen W $u Department of Genetics and Genomic Biology, The Hospital for Sick Children, Toronto, Ontario, Canada.
- 700 1_
- $a Schmidt, Ulrike $u National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK. Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.
- 700 1_
- $a Schork, Nicholas J $u J. Craig Venter Institute (JCVI), La Jolla, CA, USA.
- 700 1_
- $a Schosser, Alexandra $u Department of Psychiatry and Psychotherapy, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Seitz, Jochen $u Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, RWTH Aachen University, Aachen, Germany.
- 700 1_
- $a Slachtova, Lenka $u Department of Pediatrics and Center of Applied Genomics, First Faculty of Medicine, Charles University, Prague, Czech Republic.
- 700 1_
- $a Slagboom, P Eline $u Department of Biomedical Data Science, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a Slof-Op 't Landt, Margarita C T $u Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands. Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a Slopien, Agnieszka $u Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Sorbi, Sandro $u Department of Neuroscience, Psychology, Drug Research and Child Health (NEUROFARBA), University of Florence, Florence, Italy. IRCSS Fondazione Don Carlo Gnocchi, Florence, Italy.
- 700 1_
- $a Świątkowska, Beata $u Department of Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland.
- 700 1_
- $a Szatkiewicz, Jin P $u Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Tachmazidou, Ioanna $u Wellcome Sanger Institute, Hinxton, UK.
- 700 1_
- $a Tenconi, Elena $u Department of Neurosciences, University of Padova, Padova, Italy.
- 700 1_
- $a Tortorella, Alfonso $u Department of Psychiatry, University of Naples SUN, Naples, Italy. Department of Psychiatry, University of Perugia, Perugia, Italy.
- 700 1_
- $a Tozzi, Federica $u Brain Sciences Department, Stremble Ventures, Limassol, Cyprus.
- 700 1_
- $a Treasure, Janet $u National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK. Institute of Psychiatry, Psychology and Neuroscience, Department of Psychological Medicine, King's College London, London, UK.
- 700 1_
- $a Tsitsika, Artemis $u Adolescent Health Unit, Second Department of Pediatrics, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
- 700 1_
- $a Tyszkiewicz-Nwafor, Marta $u Department of Child and Adolescent Psychiatry, Poznan University of Medical Sciences, Poznan, Poland.
- 700 1_
- $a Tziouvas, Konstantinos $u Pediatric Intensive Care Unit, "P. & A. Kyriakou" Children's Hospital, University of Athens, Athens, Greece.
- 700 1_
- $a van Elburg, Annemarie A $u Center for Eating Disorders Rintveld, Altrecht Mental Health Institute, Zeist, the Netherlands. Faculty of Social and Behavioral Sciences, Utrecht University, Utrecht, the Netherlands.
- 700 1_
- $a van Furth, Eric F $u Center for Eating Disorders Ursula, Rivierduinen, Leiden, the Netherlands. Department of Psychiatry, Leiden University Medical Centre, Leiden, the Netherlands.
- 700 1_
- $a Wagner, Gudrun $u Eating Disorders Unit, Department of Child and Adolescent Psychiatry, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Walton, Esther $u Division of Psychological and Social Medicine and Developmental Neurosciences, Faculty of Medicine, Technische Universität Dresden, Dresden, Germany.
- 700 1_
- $a Widen, Elisabeth $u Institute for Molecular Medicine Finland, Helsinki Institute of Life Science, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Zeggini, Eleftheria $u Wellcome Sanger Institute, Hinxton, UK. Institute of Translational Genomics, Helmholtz Zentrum München, Neuherberg, Germany.
- 700 1_
- $a Zerwas, Stephanie $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Zipfel, Stephan $u Department of Internal Medicine VI, Psychosomatic Medicine and Psychotherapy, University Medical Hospital Tuebingen, Tuebingen, Germany.
- 700 1_
- $a Bergen, Andrew W $u BioRealm, LLC, Walnut, CA, USA. Oregon Research Institute, Eugene, OR, USA.
- 700 1_
- $a Boden, Joseph M $u Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
- 700 1_
- $a Brandt, Harry $u The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.
- 700 1_
- $a Crawford, Steven $u The Center for Eating Disorders at Sheppard Pratt, Baltimore, MD, USA.
- 700 1_
- $a Halmi, Katherine A $u Department of Psychiatry, Weill Cornell Medical College, New York, NY, USA.
- 700 1_
- $a Horwood, L John $u Christchurch Health and Development Study, University of Otago, Christchurch, New Zealand.
- 700 1_
- $a Johnson, Craig $u Eating Recovery Center, Denver, CO, USA.
- 700 1_
- $a Kaplan, Allan S $u Centre for Addiction and Mental Health, Toronto, Ontario, Canada. Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.
- 700 1_
- $a Kaye, Walter H $u Department of Psychiatry, University of California San Diego, San Diego, CA, USA.
- 700 1_
- $a Mitchell, James E $u Department of Psychiatry and Behavioral Science, University of North Dakota School of Medicine and Health Sciences, Fargo, ND, USA.
- 700 1_
- $a Olsen, Catherine M $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Pearson, John F $u Biostatistics and Computational Biology Unit, University of Otago, Christchurch, New Zealand.
- 700 1_
- $a Pedersen, Nancy L $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Strober, Michael $u Department of Psychiatry and Biobehavioral Science, Semel Institute for Neuroscience and Human Behavior, University of California Los Angeles, Los Angeles, CA, USA. David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
- 700 1_
- $a Werge, Thomas $u Department of Clinical Medicine, University of Copenhagen, Copenhagen, Denmark.
- 700 1_
- $a Whiteman, David C $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Woodside, D Blake $u Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada. Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada. Centre for Mental Health, University Health Network, Toronto, Ontario, Canada. Program for Eating Disorders, University Health Network, Toronto, Ontario, Canada.
- 700 1_
- $a Stuber, Garret D $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Cell Biology and Physiology, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
- 700 1_
- $a Gordon, Scott $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Grove, Jakob $u Department of Biomedicine, Aarhus University, Aarhus, Denmark. The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark. Centre for Integrative Sequencing, iSEQ, Aarhus University, Aarhus, Denmark. Bioinformatics Research Centre, Aarhus University, Aarhus, Denmark.
- 700 1_
- $a Henders, Anjali K $u Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia.
- 700 1_
- $a Juréus, Anders $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Kirk, Katherine M $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Larsen, Janne T $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark. National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark. Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.
- 700 1_
- $a Parker, Richard $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Petersen, Liselotte $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark. National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark. Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.
- 700 1_
- $a Jordan, Jennifer $u Department of Psychological Medicine, University of Otago, Christchurch, New Zealand. Canterbury District Health Board, Christchurch, New Zealand.
- 700 1_
- $a Kennedy, Martin $u Department of Pathology and Biomedical Science, University of Otago, Christchurch, New Zealand.
- 700 1_
- $a Montgomery, Grant W $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland, Australia. Queensland Brain Institute, University of Queensland, Brisbane, Queensland, Australia.
- 700 1_
- $a Wade, Tracey D $u School of Psychology, Flinders University, Adelaide, South Australia, Australia.
- 700 1_
- $a Birgegård, Andreas $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.
- 700 1_
- $a Lichtenstein, Paul $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Norring, Claes $u Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden. Center for Psychiatry Research, Stockholm Health Care Services, Stockholm City Council, Stockholm, Sweden.
- 700 1_
- $a Landén, Mikael $u Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
- 700 1_
- $a Martin, Nicholas G $u QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
- 700 1_
- $a Mortensen, Preben Bo $u The Lundbeck Foundation Initiative for Integrative Psychiatric Research (iPSYCH), Aarhus, Denmark. National Centre for Register-Based Research, Aarhus BSS, Aarhus University, Aarhus, Denmark. Centre for Integrated Register-based Research (CIRRAU), Aarhus University, Aarhus, Denmark.
- 700 1_
- $a Sullivan, Patrick F $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Breen, Gerome $u Institute of Psychiatry, Psychology and Neuroscience, Social, Genetic and Developmental Psychiatry (SGDP) Centre, King's College London, London, UK. National Institute for Health Research Biomedical Research Centre, King's College London and South London and Maudsley National Health Service Foundation Trust, London, UK.
- 700 1_
- $a Bulik, Cynthia M $u Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cynthia_bulik@med.unc.edu. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. cynthia_bulik@med.unc.edu. Department of Nutrition, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. cynthia_bulik@med.unc.edu.
- 710 2_
- $a Anorexia Nervosa Genetics Initiative
- 710 2_
- $a Eating Disorders Working Group of the Psychiatric Genomics Consortium
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