Cell surface receptors that bind somatomedins and trigger intracellular changes which influence the behavior of cells. Studies have disclosed two types of receptors for this family of peptide hormones. The type I receptor is homologous to the insulin receptor and has tyrosine kinase activity. The type II receptor is identical to the mannose-6-phosphate receptor which is important in trafficking of lysosomal enzymes.

Annotation

specifics are also available

DUI

D017451 MeSH Browser

CUI

M0026477

Previous indexing

Receptors, Endogenous Substances (1980-1992); Receptors, Insulin (1980-1989)

History note

93; was INSULIN-LIKE GROWTH FACTOR RECEPTOR (NM) 1980-92; INSULIN-LIKE GROWTH FACTORS RECEPTORS was see RECEPTORS, SOMATOMEDIN 1993

Online note

use RECEPTORS, SOMATOMEDIN (NM) to search INSULIN-LIKE GROWTH FACTOR RECEPTOR 1980-92; use RECEPTORS, SOMATOMEDIN to search INSULIN-LIKE GROWTH FACTORS RECEPTOR 1993

Public note

93; INSULIN-LIKE GROWTH FACTOR RECEPTOR was indexed under RECEPTORS, ENDOGENOUS SUBSTANCES 1980-92 & RECEPTORS, INSULIN 1980-89; INSULIN-LIKE GROWTH FACTORS RECEPTORS was see RECEPTORS, SOMATOMEDIN 1993