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Poor outcome in hypoxic endometrial carcinoma is related to vascular density
C. Reijnen, WJ. van Weelden, MSJP. Arts, JP. Peters, PF. Rijken, K. van de Vijver, M. Santacana, P. Bronsert, J. Bulten, M. Hirschfeld, E. Colas, A. Gil-Moreno, A. Reques, G. Mancebo, C. Krakstad, J. Trovik, IS. Haldorsen, J. Huvila, M. Koskas,...
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články
NLK
Free Medical Journals
od 1947 do Před 1 rokem
Freely Accessible Journals
od 1947 do Před 1 rokem
PubMed Central
od 1947 do Před 1 rokem
Europe PubMed Central
od 1947 do Před 1 rokem
Open Access Digital Library
od 1947-01-01
Open Access Digital Library
od 1999-01-01
Public Health Database (ProQuest)
od 2019-01-01 do 2021-12-31
- MeSH
- dospělí MeSH
- hypoxie buňky MeSH
- karboanhydrasa IX analýza MeSH
- lidé středního věku MeSH
- lidé MeSH
- nádory endometria krevní zásobení mortalita patologie MeSH
- patologická angiogeneze MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
Department of Gynecology and Obstetrics Faculty of Medicine Masaryk University Brno Czech Republic
Department of Obstetrics and Gynaecology Canisius Wilhelmina Hospital Nijmegen The Netherlands
Department of Obstetrics and Gynecology Haukeland University Hospital Bergen Norway
Department of Obstetrics and Gynecology Hospital del Mar PSMARB Barcelona Spain
Department of Pathology Canisius Wilhelmina Hospital Nijmegen The Netherlands
Department of Pathology Ghent University Hospital Cancer Research Institute Ghent Ghent Belgium
Department of Pathology Radboud University Medical Center Nijmegen The Netherlands
Department of Pathology University of Turku Turku Finland
Department of Radiation Oncology Radboud University Medical Center Nijmegen The Netherlands
Institute of Pathology Faculty of Medicine Masaryk University Brno Czech Republic
Institute of Pathology University Medical Center Freiburg Germany
Obstetrics and Gynecology Department Bichat Claude Bernard Hospital Paris France
Pathology Department Vall Hebron University Hospital CIBERONC Barcelona Spain
Citace poskytuje Crossref.org
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- $a Reijnen, Casper $u Department of Obstetrics and Gynaecology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands. Casper.reijnen@radboudumc.nl. Department of Obstetrics and Gynaecology, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands. Casper.reijnen@radboudumc.nl.
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- $a Poor outcome in hypoxic endometrial carcinoma is related to vascular density / $c C. Reijnen, WJ. van Weelden, MSJP. Arts, JP. Peters, PF. Rijken, K. van de Vijver, M. Santacana, P. Bronsert, J. Bulten, M. Hirschfeld, E. Colas, A. Gil-Moreno, A. Reques, G. Mancebo, C. Krakstad, J. Trovik, IS. Haldorsen, J. Huvila, M. Koskas, V. Weinberger, L. Minar, E. Jandakova, MPLM. Snijders, S. van den Berg-van Erp, HVN. Küsters-Vandevelde, X. Matias-Guiu, F. Amant, ENITEC-consortium, LFAG. Massuger, J. Bussink, JMA. Pijnenborg,
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- $a BACKGROUND: Identification of endometrial carcinoma (EC) patients at high risk of recurrence is lacking. In this study, the prognostic role of hypoxia and angiogenesis was investigated in EC patients. METHODS: Tumour slides from EC patients were stained by immunofluorescence for carbonic anhydrase IX (CAIX) as hypoxic marker and CD34 for assessment of microvessel density (MVD). CAIX expression was determined in epithelial tumour cells, with a cut-off of 1%. MVD was assessed according to the Weidner method. Correlations with disease-specific survival (DSS), disease-free survival (DFS) and distant disease-free survival (DDFS) were calculated using Kaplan-Meier curves and Cox regression analysis. RESULTS: Sixty-three (16.4%) of 385 ECs showed positive CAIX expression with high vascular density. These ECs had a reduced DSS compared to tumours with either hypoxia or high vascular density (log-rank p = 0.002). Multivariable analysis showed that hypoxic tumours with high vascular density had a reduced DSS (hazard ratio [HR] 3.71, p = 0.002), DDFS (HR 2.68, p = 0.009) and a trend for reduced DFS (HR 1.87, p = 0.054). CONCLUSIONS: This study has shown that adverse outcome in hypoxic ECs is seen in the presence of high vascular density, suggesting an important role of angiogenesis in the metastatic process of hypoxic EC. Differential adjuvant treatment might be indicated for these patients.
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