-
Something wrong with this record ?
Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips
V. Sedláková, M. Kloučková, Z. Garlíková, K. Vašíčková, J. Jaroš, M. Kandra, H. Kotasová, A. Hampl,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
NV16-31501A
MZ0
CEP Register
- MeSH
- Models, Biological * MeSH
- Cell Culture Techniques MeSH
- Respiratory System * anatomy & histology MeSH
- Lab-On-A-Chip Devices MeSH
- Humans MeSH
- Microfluidics MeSH
- Tissue Scaffolds MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20006529
- 003
- CZ-PrNML
- 005
- 20240111100149.0
- 007
- ta
- 008
- 200511s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.drudis.2019.03.006 $2 doi
- 035 __
- $a (PubMed)30877077
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Sedláková, Veronika $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; Division of Cardiac Surgery, Cardiovascular Tissue Engineering Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa K1Y 4W7, Canada. Electronic address: veronika.sedlakova@mail.muni.cz.
- 245 10
- $a Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips / $c V. Sedláková, M. Kloučková, Z. Garlíková, K. Vašíčková, J. Jaroš, M. Kandra, H. Kotasová, A. Hampl,
- 520 9_
- $a The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a buněčné kultury $7 D018929
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a laboratoř na čipu $7 D056656
- 650 _2
- $a mikrofluidika $7 D044085
- 650 12
- $a biologické modely $7 D008954
- 650 12
- $a dýchací soustava $x anatomie a histologie $7 D012137
- 650 _2
- $a tkáňové podpůrné struktury $7 D054457
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Kloučková, Michaela $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
- 700 1_
- $a Garlíková, Zuzana $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 700 1_
- $a Vašíčková, Kateřina $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic. $7 mub20181010327
- 700 1_
- $a Jaroš, Josef $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 700 1_
- $a Kandra, Mário $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 700 1_
- $a Kotasová, Hana $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
- 700 1_
- $a Hampl, Aleš $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 773 0_
- $w MED00173737 $t Drug discovery today $x 1878-5832 $g Roč. 24, č. 4 (2019), s. 971-982
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30877077 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20240111100144 $b ABA008
- 999 __
- $a ok $b bmc $g 1525387 $s 1096585
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 24 $c 4 $d 971-982 $e 20190312 $i 1878-5832 $m Drug discovery today $n Drug Discov Today Dis Mech $x MED00173737
- GRA __
- $a NV16-31501A $p MZ0
- LZP __
- $a Pubmed-20200511
