-
Je něco špatně v tomto záznamu ?
Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips
V. Sedláková, M. Kloučková, Z. Garlíková, K. Vašíčková, J. Jaroš, M. Kandra, H. Kotasová, A. Hampl,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, přehledy
Grantová podpora
NV16-31501A
MZ0
CEP - Centrální evidence projektů
- MeSH
- biologické modely * MeSH
- buněčné kultury MeSH
- dýchací soustava * anatomie a histologie MeSH
- laboratoř na čipu MeSH
- lidé MeSH
- mikrofluidika MeSH
- tkáňové podpůrné struktury MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- přehledy MeSH
The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20006529
- 003
- CZ-PrNML
- 005
- 20240111100149.0
- 007
- ta
- 008
- 200511s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.drudis.2019.03.006 $2 doi
- 035 __
- $a (PubMed)30877077
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Sedláková, Veronika $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; Division of Cardiac Surgery, Cardiovascular Tissue Engineering Laboratory, University of Ottawa Heart Institute, 40 Ruskin Street, Ottawa K1Y 4W7, Canada. Electronic address: veronika.sedlakova@mail.muni.cz.
- 245 10
- $a Options for modeling the respiratory system: inserts, scaffolds and microfluidic chips / $c V. Sedláková, M. Kloučková, Z. Garlíková, K. Vašíčková, J. Jaroš, M. Kandra, H. Kotasová, A. Hampl,
- 520 9_
- $a The human respiratory system is continuously exposed to varying levels of hazardous substances ranging from environmental toxins to purposely administered drugs. If the noxious effects exceed the inherent regenerative capacity of the respiratory system, injured tissue undergoes complex remodeling that can significantly affect lung function and lead to various diseases. Advanced near-to-native in vitro lung models are required to understand the mechanisms involved in pulmonary damage and repair and to reliably test the toxicity of compounds to lung tissue. This review is an overview of the development of in vitro respiratory system models used for study of lung diseases. It includes discussion of using these models for environmental toxin assessment and pulmonary toxicity screening.
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a buněčné kultury $7 D018929
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a laboratoř na čipu $7 D056656
- 650 _2
- $a mikrofluidika $7 D044085
- 650 12
- $a biologické modely $7 D008954
- 650 12
- $a dýchací soustava $x anatomie a histologie $7 D012137
- 650 _2
- $a tkáňové podpůrné struktury $7 D054457
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Kloučková, Michaela $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
- 700 1_
- $a Garlíková, Zuzana $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 700 1_
- $a Vašíčková, Kateřina $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic. $7 mub20181010327
- 700 1_
- $a Jaroš, Josef $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 700 1_
- $a Kandra, Mário $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 700 1_
- $a Kotasová, Hana $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic.
- 700 1_
- $a Hampl, Aleš $u Department of Histology and Embryology, Faculty of Medicine, Masaryk University, Kamenice 753/5, 625 00 Brno, Czech Republic; International Clinical Research Center, St Anne's University Hospital Brno, Pekařská 664/53, 656 91 Brno, Czech Republic.
- 773 0_
- $w MED00173737 $t Drug discovery today $x 1878-5832 $g Roč. 24, č. 4 (2019), s. 971-982
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/30877077 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200511 $b ABA008
- 991 __
- $a 20240111100144 $b ABA008
- 999 __
- $a ok $b bmc $g 1525387 $s 1096585
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 24 $c 4 $d 971-982 $e 20190312 $i 1878-5832 $m Drug discovery today $n Drug Discov Today Dis Mech $x MED00173737
- GRA __
- $a NV16-31501A $p MZ0
- LZP __
- $a Pubmed-20200511
