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Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials

C. Zoccali, PJ. Blankestijn, A. Bruchfeld, G. Capasso, D. Fliser, D. Fouque, D. Goumenos, M. Ketteler, Z. Massy, I. Rychlık, M. Jose Soler, K. Stevens, G. Spasovski, C. Wanner,

. 2019 ; 34 (7) : 1112-1114. [pub] 20190701

Language English Country Great Britain

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc20006561

The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.

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$a The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.
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$a Blankestijn, Peter J $u Department of Nephrology, University Medical Center, Utrecht, The Netherlands.
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$a Bruchfeld, Annette $u Department of Renal Medicine, Karolinska University Hospital, Stockholm, Sweden.
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$a Capasso, Giovambattista $u Department of Nephrology, University Campania 'Luigi Vanvitelli', Naples, Italy.
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$a Fliser, Danilo $u Internal Medicine IV, Renal and Hypertensive Disease, University Medical Center, Homburg/Saar, Germany.
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$a Fouque, Denis $u Department of Nephrology, Dialysis, Nutrition, Centre Hospitalier Lyon Sud, Pierre Bénite Cedex, France.
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$a Goumenos, Dimitrios $u Department of Nephrology and Renal Transplantation, Patras University Hospital, Patras, Greece.
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$a Ketteler, Markus $u Nephrologische Klinik Klinikum Coburg, Coburg, Germany.
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$a Massy, Ziad $u Division of Nephrology, Ambroise Paré Hospital, Paris Ile de France West University (UVSQ), Villejuif, France.
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$a Rychlık, Ivan $u First Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
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$a Jose Soler, Maria $u Department of Nephrology, Hospital Universitari Vall d'Hebron, Nephrology Research Group, Vall d'Hebron Research Institute (VHIR), Barcelona, Spain.
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$a Stevens, Kate $u Glasgow Renal and Transplant Unit, Queen Elizabeth University Hospital, Glasgow, UK.
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$a Spasovski, Goce $u Department of Nephrology, Medical Faculty, University of Skopje, Skopje, Former Yugoslav Republic of Macedonia.
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$a Wanner, Christoph $u Division of Nephrology, University of Würzburg, Würzburg, Germany.
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