Children of a lesser god: exclusion of chronic kidney disease patients from clinical trials
Language English Country Great Britain, England Media print
Document type Journal Article, Review
PubMed
30815678
DOI
10.1093/ndt/gfz023
PII: 5366221
Knihovny.cz E-resources
- Keywords
- CKD, cardiovascular, clinical trial, diabetes mellitus, guidelines,
- MeSH
- Global Health MeSH
- Renal Insufficiency, Chronic epidemiology therapy MeSH
- Child MeSH
- Incidence MeSH
- Cardiovascular Diseases epidemiology MeSH
- Clinical Trials as Topic organization & administration MeSH
- Comorbidity MeSH
- Humans MeSH
- Guidelines as Topic * MeSH
- Patient Selection * MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
The exclusion of chronic kidney disease (CKD) patients from clinical trials-particularly cardiovascular trials-remains a long-standing, unsolved problem, which prevents the optimization of clinical care in these patients. The situation recalls the insufficient recruitment of women in cardiovascular trials until the 1980s, a problem that was only resolved following regulatory interventions. Regulatory agencies are in a unique position to promote recruitment of CKD patients in clinical trials. The main stakeholders, namely patients' associations and scientific societies, should make major lobbying efforts to persuade these agencies that the issue is an absolute public health priority.
1st Department of Internal Medicine 3rd Faculty of Medicine Charles University Prague Czech Republic
CNR IFC c o Ospedali Riuniti Reggio Calabria Italy
Department of Nephrology and Renal Transplantation Patras University Hospital Patras Greece
Department of Nephrology Dialysis Nutrition Centre Hospitalier Lyon Sud Pierre Bénite Cedex France
Department of Nephrology University Campania 'Luigi Vanvitelli' Naples Italy
Department of Nephrology University Medical Center Utrecht The Netherlands
Department of Renal Medicine Karolinska University Hospital Stockholm Sweden
Division of Nephrology Ambroise Paré Hospital Paris Ile de France West University Villejuif France
Division of Nephrology University of Würzburg Würzburg Germany
Glasgow Renal and Transplant Unit Queen Elizabeth University Hospital Glasgow UK
Internal Medicine 4 Renal and Hypertensive Disease University Medical Center Homburg Saar Germany
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