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Antifouling Microparticles To Scavenge Lipopolysaccharide from Human Blood Plasma
M. Vorobii, NY. Kostina, K. Rahimi, S. Grama, D. Söder, O. Pop-Georgievski, A. Sturcova, D. Horak, O. Grottke, S. Singh, C. Rodriguez-Emmenegger,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- adsorpce MeSH
- akrylamidy metabolismus MeSH
- biokompatibilní potahované materiály farmakologie MeSH
- bioznečištění prevence a kontrola MeSH
- epoxidové sloučeniny metabolismus MeSH
- krevní plazma metabolismus MeSH
- lidé MeSH
- lipopolysacharidy metabolismus MeSH
- methakryláty metabolismus MeSH
- polymerizace účinky léků MeSH
- polymery chemie MeSH
- polymyxin B farmakologie MeSH
- povrchové vlastnosti účinky léků MeSH
- proteiny metabolismus MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Currently, one of the most promising treatments of lipopolysaccharides (LPS)-induced sepsis is based on hemofiltration. Nevertheless, proteins rapidly adsorbed on the artificial surface of membranes which leads to activation of coagulation impairing effective scavenging of the endotoxins. To overcome this challenge, we designed polymer-brush-coated microparticles displaying antifouling properties and functionalized them with polymyxin B (PMB) to specifically scavenge LPS the most common endotoxin. Poly[( N-(2-hydroxypropyl) methacrylamide)- co-(carboxybetaine methacrylamide)] brushes were grafted from poly(glycidyl methacrylate) microparticles using photoinduced single-electron transfer living radical polymerization (SET-LRP). Notably, only parts-per-million of copper catalyst were necessary to achieve brushes able to repel adsorption of proteins from blood plasma. The open porosity of the particles, accessible to polymerization, enabled us to immobilize sufficient PMB to selectively scavenge LPS from blood plasma.
Citace poskytuje Crossref.org
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