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Patterns of proton therapy use in pediatric cancer management in 2016: An international survey
N. Journy, DJ. Indelicato, DR. Withrow, T. Akimoto, C. Alapetite, M. Araya, A. Chang, JH. Chang, B. Chon, ME. Confer, Y. Demizu, R. Dendale, J. Doyen, R. Ermoian, K. Gurtner, C. Hill-Kayser, H. Iwata, JY. Kim, Y. Kwok, NN. Laack, C. Lee, DH. Lim,...
Language English Country Ireland
Document type Journal Article, Multicenter Study, Observational Study, Research Support, N.I.H., Intramural, Research Support, Non-U.S. Gov't
- MeSH
- Radiotherapy Dosage MeSH
- Child MeSH
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Neoplasms epidemiology radiotherapy MeSH
- Pediatrics methods statistics & numerical data MeSH
- Child, Preschool MeSH
- Proton Therapy methods statistics & numerical data MeSH
- Surveys and Questionnaires MeSH
- Check Tag
- Child MeSH
- Adult MeSH
- Infant MeSH
- Humans MeSH
- Adolescent MeSH
- Young Adult MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Multicenter Study MeSH
- Observational Study MeSH
- Research Support, Non-U.S. Gov't MeSH
- Research Support, N.I.H., Intramural MeSH
PURPOSE: To facilitate the initiation of observational studies on late effects of proton therapy in pediatric patients, we report on current patterns of proton therapy use worldwide in patients aged less than 22 years. MATERIALS & METHODS: Fifty-four proton centers treating pediatric patients in 2016 in 11 countries were invited to respond to a survey about the number of patients treated during that year by age group, intent of treatment, delivery technique and tumor types. RESULTS: Among the 40 participating centers (participation rate: 74%), a total of 1,860 patients were treated in 2016 (North America: 1205, Europe: 432, Asia: 223). The numbers of patients per center ranged from 1 to 206 (median: 29). Twenty-four percent of the patients were <5 years of age, and 50% <10 years. More than 30 pediatric tumor types were identified, mainly treated with curative intent: 48% were CNS, 25% extra-cranial sarcomas, 7% neuroblastoma, and 5% hematopoietic tumors. About half of the patients were treated with pencil beam scanning. Treatment patterns were broadly similar across the three continents. CONCLUSION: To our knowledge, this survey provides the first worldwide assessment of proton therapy use for pediatric cancer management. Since previous estimates in the United States and Europe, CNS tumors remain the cancer types most commonly treated with protons in 2016. However, the proportion of extra-cranial tumors is growing worldwide. The typically low numbers of patients treated in each center indicate the need for international research collaborations to assess long-term outcomes of proton therapy in pediatric patients.
Aizawa Hospital Proton Therapy Center Nagano Japan
California Protons San Diego United States
Center for Proton Therapy Paul Scherrer Institute Switzerland
Danish Centre for Particle Therapy Aarhus Denmark
Departement of Radiation Oncology University of Maryland School of Medicine Baltimore United States
Department of Radiation Oncology Hokkaido University Faculty of Medicine Sapporo Japan
Department of Radiation Oncology Mayo Clinic Rochester United States
Francis H Burr Proton Therapy Center Massachusetts General Hospital Boston United States
Hyogo Ion Beam Medical Center Tatsuno Japan
Institut Curie Proton therapie Centre Orsay France
Loma Linda University Medical Center United States
Mayo Clinic Arizona Phoenix United States
Medipolis Proton Therapy and Research Center Kaghosima Japan
Nagoya Proton Therapy Center Nagoya city Japan
National Cancer Center Hospital East Kashiwa Japan
Northwestern Medicine Chicago Proton Center Warrenville United States
Orlando Health UF Health Cancer Center United States
ProCure Proton Therapy Center Oklahoma City United States
ProCure Proton Therapy Center United States
Proton Therapy Center Czech s r o Praha Czech Republic
Proton Therapy Center Fukui Prefectural Hospital Japan
Proton Therapy Center Trento Italy
ProtonTherapy Center National Cancer Center Goyang si South Korea
Provision Cares Proton Therapy Center Knoxville United States
Rinecker Proton Therapy Center Muenchen Germany
Rutgers Cancer Institute of New Jersey New Brunswick United States
S Lee Kling Proton Therapy Center Washington University in St Louis United States
SCCA Proton Therapy Seattle United States
Southern TOHOKU Proton Therapy Center Koriyama Japan
Texas Center for Proton Therapy Irving United States
The Skandion Clinic Uppsala Sweden
Universitäts Protonentherapie Dresden Universitätsklinikum Carl Gustav Carus Germany
University of Florida Department of Radiation Oncology Jacksonville United States
Vanderbilt University Medical Center Department of Radiation Oncology Nashville United States
References provided by Crossref.org
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