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Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study
F. Qian, S. Wang, J. Mitchell, L. McGuffog, D. Barrowdale, G. Leslie, JC. Oosterwijk, WK. Chung, DG. Evans, C. Engel, K. Kast, CM. Aalfs, MA. Adank, J. Adlard, BA. Agnarsson, K. Aittomäki, E. Alducci, IL. Andrulis, BK. Arun, MGEM. Ausems, J....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
U10 CA180868
NCI NIH HHS - United States
203477/Z/16/Z
Wellcome Trust - United Kingdom
UL1 TR001863
NCATS NIH HHS - United States
P50 CA116201
NCI NIH HHS - United States
UG1 CA233191
NCI NIH HHS - United States
10118
Cancer Research UK - United Kingdom
UG1 CA233290
NCI NIH HHS - United States
UG1 CA189867
NCI NIH HHS - United States
NLK
Free Medical Journals
od 1996 do Před 1 rokem
Open Access Digital Library
od 1996-01-01
PubMed
30312457
DOI
10.1093/jnci/djy132
Knihovny.cz E-zdroje
- MeSH
- dospělí MeSH
- genetická predispozice k nemoci MeSH
- index tělesné hmotnosti * MeSH
- jednonukleotidový polymorfismus MeSH
- lidé MeSH
- mendelovská randomizace * MeSH
- mutace * MeSH
- nádory prsu etiologie patologie MeSH
- prognóza MeSH
- protein BRCA1 genetika MeSH
- protein BRCA2 genetika MeSH
- rizikové faktory MeSH
- tělesná výška * MeSH
- Check Tag
- dospělí MeSH
- lidé MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.
Cancer Genetics and Prevention Program University of California San Francisco San Francisco CA
Cancer Risk and Prevention Clinic Dana Farber Cancer Institute Boston MA
Center for Genomic Medicine Rigshospitalet Copenhagen University Hospital Copenhagen Denmark
Center for Medical Genetics NorthShore University HealthSystem Evanston IL
Centre for Cancer Research and Cell Biology Queens University Belfast Belfast UK
Centre for Medical Genetics Ghent University Ghent Belgium
City of Hope Clinical Cancer Genetics Community Research Network Duarte CA
Clinical Cancer Genetics City of Hope Duarte CA
Clinical Genetics Department St Michael's Hospital Bristol UK
Clinical Genetics Guy's and St Thomas' NHS Foundation Trust London UK
Clinical Genetics Karolinska Institutet Stockholm Sweden
Clinical Genetics Service Department of Medicine Memorial Sloan Kettering Cancer Center New York NY
Department of Breast Medical Oncology University of Texas MD Anderson Cancer Center Houston TX
Department of Cancer Epidemiology Moffitt Cancer Center Tampa FL
Department of Clinical Genetics Academic Medical Center Amsterdam the Netherlands
Department of Clinical Genetics Erasmus University Medical Center Rotterdam the Netherlands
Department of Clinical Genetics Fox Chase Cancer Center Philadelphia PA
Department of Clinical Genetics Helsinki University Hospital University of Helsinki Helsinki Finland
Department of Clinical Genetics Leiden University Medical Center Leiden the Netherlands
Department of Clinical Genetics Odense University Hospital Odense C Denmark
Department of Clinical Genetics South Glasgow University Hospitals Glasgow UK
Department of Clinical Genetics VU University Medical Center Amsterdam the Netherlands
Department of Epidemiology Mailman School of Public Health Columbia University New York NY
Department of Epidemiology Netherlands Cancer Institute Amsterdam the Netherlands
Department of Genetics and Pathology Pomeranian Medical University Szczecin Poland
Department of Genetics University of Pretoria Arcadia South Africa
Department of Gynaecology and Obstetrics University of Ulm Ulm Germany
Department of Human Genetics Radboud University Medical Center Nijmegen the Netherlands
Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN
Department of Medical Genetics University Medical Center Utrecht the Netherlands
Department of Medical Oncology Beth Israel Deaconess Medical Center Boston MA
Department of Medicine Huntsman Cancer Institute at the University of Utah Salt Lake City UT
Department of Medicine The University of Chicago Chicago IL
Department of Molecular Genetics National Institute of Oncology Budapest Hungary
Department of Molecular Medicine University La Sapienza Rome Italy
Department of Oncology Lund University and Skåne University Hospital Lund Sweden
Department of Pathology and Laboratory Medicine Kansas University Medical Center Kansas City KS
Department of Population Sciences Beckman Research Institute of City of Hope Duarte CA
Department of Surgery Daerim Saint Mary's Hospital Seoul Korea
Department of Surgery Seoul National University Bundang Hospital Seongnam Korea
Department of Surgery Soonchunhyang University Hospital Bucheon Bucheon Korea
Department of Surgery Ulsan University College of Medicine and Asan Medical Center Seoul Korea
Department of Urology Medical University of Vienna Vienna Austria
Departments of Pediatrics and Medicine Columbia University New York NY
Division of Gynaecology and Obstetrics Technische Universität München Munich Germany
IFOM The FIRC Institute of Molecular Oncology Milan Italy
Institute of Human Genetics University Hospital Heidelberg Heidelberg Germany
Lombardi Comprehensive Cancer Center Georgetown University Washington DC
Molecular Oncology Laboratory Hospital Clinico San Carlos IdISSC CIBERONC Madrid Spain
N N Petrov Institute of Oncology St Petersburg Russia
Ocogenetics Team The Institute of Cancer Research and Royal Marsden NHS Foundation Trust London UK
Oncogenetics Group Clinical and Molecular Genetics Area Vall d'Hebron Institute of Oncology
Service de Génétique Institut Curie Paris France
The Ohio State University Columbus Cancer Council Columbus OH
The Susanne Levy Gertner Oncogenetics Unit Chaim Sheba Medical Center Ramat Gan Israel
Unit of Medical Genetics Department of Medical Oncology and Hematology Fondazione IRCCS Milan Italy
Unité d'Oncogénétique CHU Arnaud de Villeneuve Montpellier France
Unité de Prévention et d'Epidémiologie Génétique Centre Léon Bérard Lyon France
Citace poskytuje Crossref.org
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- $a Qian, Frank $u Department of Medicine, The University of Chicago, Chicago, IL.
- 245 10
- $a Height and Body Mass Index as Modifiers of Breast Cancer Risk in BRCA1/2 Mutation Carriers: A Mendelian Randomization Study / $c F. Qian, S. Wang, J. Mitchell, L. McGuffog, D. Barrowdale, G. Leslie, JC. Oosterwijk, WK. Chung, DG. Evans, C. Engel, K. Kast, CM. Aalfs, MA. Adank, J. Adlard, BA. Agnarsson, K. Aittomäki, E. Alducci, IL. Andrulis, BK. Arun, MGEM. Ausems, J. Azzollini, E. Barouk-Simonet, J. Barwell, M. Belotti, J. Benitez, A. Berger, A. Borg, AR. Bradbury, J. Brunet, SS. Buys, T. Caldes, MA. Caligo, I. Campbell, SM. Caputo, J. Chiquette, KBM. Claes, J. Margriet Collée, FJ. Couch, I. Coupier, MB. Daly, R. Davidson, O. Diez, SM. Domchek, A. Donaldson, CM. Dorfling, R. Eeles, L. Feliubadaló, L. Foretova, J. Fowler, E. Friedman, D. Frost, PA. Ganz, J. Garber, V. Garcia-Barberan, G. Glendon, AK. Godwin, EB. Gómez Garcia, J. Gronwald, E. Hahnen, U. Hamann, A. Henderson, CB. Hendricks, JL. Hopper, PJ. Hulick, EN. Imyanitov, C. Isaacs, L. Izatt, Á. Izquierdo, A. Jakubowska, K. Kaczmarek, E. Kang, BY. Karlan, CM. Kets, SW. Kim, Z. Kim, A. Kwong, Y. Laitman, C. Lasset, M. Hyuk Lee, J. Won Lee, J. Lee, J. Lester, F. Lesueur, JT. Loud, J. Lubinski, N. Mebirouk, HEJ. Meijers-Heijboer, A. Meindl, A. Miller, M. Montagna, TM. Mooij, PJ. Morrison, E. Mouret-Fourme, KL. Nathanson, SL. Neuhausen, H. Nevanlinna, D. Niederacher, FC. Nielsen, RL. Nussbaum, K. Offit, E. Olah, KR. Ong, L. Ottini, SK. Park, P. Peterlongo, G. Pfeiler, CM. Phelan, B. Poppe, N. Pradhan, P. Radice, SJ. Ramus, J. Rantala, M. Robson, GC. Rodriguez, RK. Schmutzler, CG. Hutten Selkirk, PD. Shah, J. Simard, CF. Singer, J. Sokolowska, D. Stoppa-Lyonnet, C. Sutter, Y. Yen Tan, RM. Teixeira, SH. Teo, MB. Terry, M. Thomassen, M. Tischkowitz, AE. Toland, KM. Tucker, N. Tung, CJ. van Asperen, K. van Engelen, EJ. van Rensburg, S. Wang-Gohrke, B. Wappenschmidt, JN. Weitzel, D. Yannoukakos, GEMO Study Collaborators, HEBON, EMBRACE, MH. Greene, MA. Rookus, DF. Easton, G. Chenevix-Trench, AC. Antoniou, DE. Goldgar, OI. Olopade, TR. Rebbeck, D. Huo,
- 520 9_
- $a BACKGROUND: BRCA1/2 mutations confer high lifetime risk of breast cancer, although other factors may modify this risk. Whether height or body mass index (BMI) modifies breast cancer risk in BRCA1/2 mutation carriers remains unclear. METHODS: We used Mendelian randomization approaches to evaluate the association of height and BMI on breast cancer risk, using data from the Consortium of Investigators of Modifiers of BRCA1/2 with 14 676 BRCA1 and 7912 BRCA2 mutation carriers, including 11 451 cases of breast cancer. We created a height genetic score using 586 height-associated variants and a BMI genetic score using 93 BMI-associated variants. We examined both observed and genetically determined height and BMI with breast cancer risk using weighted Cox models. All statistical tests were two-sided. RESULTS: Observed height was positively associated with breast cancer risk (HR = 1.09 per 10 cm increase, 95% confidence interval [CI] = 1.0 to 1.17; P = 1.17). Height genetic score was positively associated with breast cancer, although this was not statistically significant (per 10 cm increase in genetically predicted height, HR = 1.04, 95% CI = 0.93 to 1.17; P = .47). Observed BMI was inversely associated with breast cancer risk (per 5 kg/m2 increase, HR = 0.94, 95% CI = 0.90 to 0.98; P = .007). BMI genetic score was also inversely associated with breast cancer risk (per 5 kg/m2 increase in genetically predicted BMI, HR = 0.87, 95% CI = 0.76 to 0.98; P = .02). BMI was primarily associated with premenopausal breast cancer. CONCLUSION: Height is associated with overall breast cancer and BMI is associated with premenopausal breast cancer in BRCA1/2 mutation carriers. Incorporating height and BMI, particularly genetic score, into risk assessment may improve cancer management.
- 650 _2
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- 700 1_
- $a Wang, Shengfeng $u Center for Clinical Cancer Genetics, The University of Chicago, Chicago, IL. Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, China.
- 700 1_
- $a Mitchell, Jonathan $u Division of Gastroenterology, Department of Hepatology and Nutrition, Children's Hospital of Philadelphia, Philadelphia, PA.
- 700 1_
- $a McGuffog, Lesley $u Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Barrowdale, Daniel $u Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Leslie, Goska $u Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Oosterwijk, Jan C $u Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
- 700 1_
- $a Chung, Wendy K $u Departments of Pediatrics and Medicine, Columbia University, New York, NY.
- 700 1_
- $a Evans, D Gareth $u Division of Evolution and Genomic Sciences, Genomic Medicine, Manchester Academic Health Sciences Centre, University of Manchester, Central Manchester University Hospitals, NHS Foundation Trust, Manchester, UK.
- 700 1_
- $a Engel, Christoph $u Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. LIFE - Leipzig Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany.
- 700 1_
- $a Kast, Karin $u Department of Gynecology and Obstetrics, Technical University of Dresden, Dresden, Germany. Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Aalfs, Cora M $u Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands. Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL. The University of Chicago Pritzker School of Medicine, Chicago, IL.
- 700 1_
- $a Adank, Muriel A $u Family Cancer Clinic, Netherlands Cancer Institute, Antoni van Leeuwenhoek Hospital, Amsterdam, the Netherlands.
- 700 1_
- $a Adlard, Julian $u Yorkshire Regional Genetics Service, Chapel Allerton Hospital, Leeds, UK. Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Agnarsson, Bjarni A $u Department of Pathology, National Institute of Oncology, Budapest, Hungary. School of Medicine, University of Iceland, Reykjavik, Iceland.
- 700 1_
- $a Aittomäki, Kristiina $u Department of Clinical Genetics, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
- 700 1_
- $a Alducci, Elisa $u Immunology and Molecular Oncology Unit, Veneto Institute of Oncology IOV - IRCCS, Padua, Italy. Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Andrulis, Irene L $u Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada. Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada.
- 700 1_
- $a Arun, Banu K $u Department of Breast Medical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX.
- 700 1_
- $a Ausems, Margreet G E M $u Department of Medical Genetics, University Medical Center, Utrecht, the Netherlands.
- 700 1_
- $a Azzollini, Jacopo $u Unit of Medical Genetics, Department of Medical Oncology and Hematology, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
- 700 1_
- $a Barouk-Simonet, Emmanuelle $u Oncogénétique, Institut Bergonié, Bordeaux, France. Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS.
- 700 1_
- $a Barwell, Julian $u Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK. Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.
- 700 1_
- $a Belotti, Muriel $u Service de Génétique, Institut Curie, Paris, France.
- 700 1_
- $a Benitez, Javier $u Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA.
- 700 1_
- $a Berger, Andreas $u Department of Oncology, Lund University and Skåne University Hospital, Lund, Sweden.
- 700 1_
- $a Borg, Ake $u Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA. Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.
- 700 1_
- $a Bradbury, Angela R $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
- 700 1_
- $a Brunet, Joan $u Service de Génétique, Institut Curie, Paris, France. Human Cancer Genetics Program, Spanish National Cancer Research Centre, Madrid, Spain. Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Buys, Saundra S $u Department of Medicine, Huntsman Cancer Institute at the University of Utah, Salt Lake City, UT.
- 700 1_
- $a Caldes, Trinidad $u Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain.
- 700 1_
- $a Caligo, Maria A $u Section of Genetic Oncology, Department of Laboratory Medicine, University and University Hospital of Pisa, Pisa, Italy.
- 700 1_
- $a Campbell, Ian $u Peter MacCallum Cancer Center, Melbourne, Victoria, Australia. Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Caputo, Sandrine M $u Leicestershire Clinical Genetics Service, University Hospitals of Leicester NHS Trust, Leicester, UK. Service de Génétique, Institut Curie, Paris, France.
- 700 1_
- $a Chiquette, Jocelyne $u Unité de recherche en santé des populations, Centre des maladies du sein Deschênes-Fabia, Hôpital du Saint-Sacrement, Québec, QC, Canada.
- 700 1_
- $a Claes, Kathleen B M $u Centre for Medical Genetics, Ghent University, Ghent, Belgium.
- 700 1_
- $a Margriet Collée, J $u Department of Clinical Genetics, Erasmus University Medical Center, Rotterdam, the Netherlands.
- 700 1_
- $a Couch, Fergus J $u Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
- 700 1_
- $a Coupier, Isabelle $u Unité d'Oncogénétique, CHU Arnaud de Villeneuve, Montpellier, France.
- 700 1_
- $a Daly, Mary B $u Department of Clinical Genetics, Fox Chase Cancer Center, Philadelphia, PA.
- 700 1_
- $a Davidson, Rosemarie $u Department of Clinical Genetics, South Glasgow University Hospitals, Glasgow, UK.
- 700 1_
- $a Diez, Orland $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
- 700 1_
- $a Domchek, Susan M $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
- 700 1_
- $a Donaldson, Alan $u Oncogenetics Group, Clinical and Molecular Genetics Area, Vall d'Hebron Institute of Oncology (VHIO), University Hospital, Vall d'Hebron, Barcelona, Spain (OD); Clinical Genetics Department, St Michael's Hospital, Bristol, UK.
- 700 1_
- $a Dorfling, Cecilia M $u Department of Genetics, University of Pretoria, Arcadia, South Africa. City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA.
- 700 1_
- $a Eeles, Ros $u Ocogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, London, UK.
- 700 1_
- $a Feliubadaló, Lidia $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Foretova, Lenka $u Molecular Diagnostic Unit, Hereditary Cancer Program, ICO-IDIBELL (Catalan Institute of Oncology, Bellvitge Biomedical Research Institute), CIBERONC, Barcelona, Spain. Department of Cancer Epidemiology and Genetics, Masaryk Memorial Cancer Institute, Brno, Czech Republic.
- 700 1_
- $a Fowler, Jeffrey $u The Ohio State University, Columbus Cancer Council, Columbus, OH.
- 700 1_
- $a Friedman, Eitan $u The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel. Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel.
- 700 1_
- $a Frost, Debra $u Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Ganz, Patricia A $u Schools of Medicine and Public Health, Division of Cancer Prevention & Control Research, Jonsson Comprehensive Cancer Center, University of California Los Angeles, CA.
- 700 1_
- $a Garber, Judy $u Cancer Risk and Prevention Clinic, Dana-Farber Cancer Institute, Boston, MA.
- 700 1_
- $a Garcia-Barberan, Vanesa $u Molecular Oncology Laboratory, Hospital Clinico San Carlos, IdISSC, CIBERONC, Madrid, Spain.
- 700 1_
- $a Glendon, Gord $u Fred A. Litwin Center for Cancer Genetics, Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, ON, Canada.
- 700 1_
- $a Godwin, Andrew K $u Department of Pathology and Laboratory Medicine, Kansas University Medical Center, Kansas City, KS.
- 700 1_
- $a Gómez Garcia, Encarna B $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Gronwald, Jacek $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Hahnen, Eric $u Centers for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 700 1_
- $a Hamann, Ute
- 700 1_
- $a Henderson, Alex $u Institute of Genetic Medicine, Centre for Life, Newcastle Upon Tyne Hospitals NHS Trust, Newcastle upon Tyne, UK.
- 700 1_
- $a Hendricks, Carolyn B $u City of Hope Clinical Cancer Genetics Community Research Network, Duarte, CA.
- 700 1_
- $a Hopper, John L $u Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.
- 700 1_
- $a Hulick, Peter J $u Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL. The University of Chicago Pritzker School of Medicine, Chicago, IL.
- 700 1_
- $a Imyanitov, Evgeny N $u N.N. Petrov Institute of Oncology, St. Petersburg, Russia.
- 700 1_
- $a Isaacs, Claudine $u Lombardi Comprehensive Cancer Center, Georgetown University, Washington, DC (CI).
- 700 1_
- $a Izatt, Louise $u Clinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
- 700 1_
- $a Izquierdo, Ángel $u Genetic Counseling Unit, Hereditary Cancer Program, IDIBGI (Institut d'Investigació Biomèdica de Girona), Catalan Institute of Oncology, CIBERONC, Girona, Spain.
- 700 1_
- $a Jakubowska, Anna $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Kaczmarek, Katarzyna $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Kang, Eunyoung $u Department of Surgery, Seoul National University Bundang Hospital, Seongnam, Korea.
- 700 1_
- $a Karlan, Beth Y $u Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA.
- 700 1_
- $a Kets, Carolien M $u Department of Human Genetics, Radboud University Medical Center, Nijmegen, the Netherlands.
- 700 1_
- $a Kim, Sung-Won $u Department of Surgery, Daerim Saint Mary's Hospital, Seoul, Korea.
- 700 1_
- $a Kim, Zisun $u Department of Surgery, Soonchunhyang University Hospital Bucheon, Bucheon, Korea.
- 700 1_
- $a Kwong, Ava $u Hong Kong Hereditary Breast Cancer Family Registry, Happy Valley, Hong Kong. Department of Surgery, The University of Hong Kong, Pok Fu Lam, Hong Kong. Department of Surgery, Hong Kong Sanatorium and Hospital, Happy Valley, Hong Kong.
- 700 1_
- $a Laitman, Yael $u The Susanne Levy Gertner Oncogenetics Unit, Chaim Sheba Medical Center, Ramat Gan, Israel.
- 700 1_
- $a Lasset, Christine $u Unité de Prévention et d'Epidémiologie Génétique, Centre Léon Bérard, Lyon, France.
- 700 1_
- $a Hyuk Lee, Min $u Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea.
- 700 1_
- $a Won Lee, Jong $u Department of Surgery, Ulsan University College of Medicine and Asan Medical Center, Seoul, Korea.
- 700 1_
- $a Lee, Jihyoun $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands. Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA. Department of Surgery, Soonchunhyang University College of Medicine and Soonchunhyang University Hospital, Seoul, Korea.
- 700 1_
- $a Lester, Jenny $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Lesueur, Fabienne $u Genetic Epidemiology of Cancer team, Institut Curie, Paris, France. U900, INSERM, Paris, France. PSL University, Paris, France. Mines ParisTech, Fontainebleau, France.
- 700 1_
- $a Loud, Jennifer T $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
- 700 1_
- $a Lubinski, Jan $u Department of Clinical Genetics and GROW, School for Oncology and Developmental Biology, Maastricht University Medical Center, Maastricht, the Netherlands.
- 700 1_
- $a Mebirouk, Noura $u Genetic Epidemiology of Cancer team, Institut Curie, Paris, France. U900, INSERM, Paris, France. PSL University, Paris, France. Mines ParisTech, Fontainebleau, France.
- 700 1_
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- 700 1_
- $a Meindl, Alfons $u Division of Gynaecology and Obstetrics, Technische Universität München, Munich, Germany. NRG Oncology, Statistics and Data Management Center, Roswell Park Cancer Institute, Buffalo, NY.
- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
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- 700 1_
- $a Nielsen, Finn C $u Center for Genomic Medicine, Rigshospitalet, Copenhagen University Hospital, Copenhagen, Denmark.
- 700 1_
- $a Nussbaum, Robert L $u Cancer Genetics and Prevention Program, University of California San Francisco, San Francisco, CA.
- 700 1_
- $a Offit, Kenneth $u Clinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY. Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.
- 700 1_
- $a Olah, Edith $u Department of Molecular Genetics, National Institute of Oncology, Budapest, Hungary.
- 700 1_
- $a Ong, Kai-Ren $u West Midlands Regional Genetics Service, Birmingham Women's Hospital Healthcare NHS Trust, Birmingham, UK.
- 700 1_
- $a Ottini, Laura $u Department of Molecular Medicine, University La Sapienza, Rome, Italy.
- 700 1_
- $a Park, Sue K $u Departments of Preventive Medicine and Biomedical Sciences, and Cancer Research Institute, Seoul National University, Seoul, Korea.
- 700 1_
- $a Peterlongo, Paolo $u IFOM, The FIRC (Italian Foundation for Cancer Research) Institute of Molecular Oncology, Milan, Italy.
- 700 1_
- $a Pfeiler, Georg $u Department of Urology, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Phelan, Catherine M $u Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, FL.
- 700 1_
- $a Poppe, Bruce $u Centre for Medical Genetics, Ghent University, Ghent, Belgium.
- 700 1_
- $a Pradhan, Nisha $u Clinical Genetics Research Laboratory, Department of Cancer Biology and Genetics, Memorial Sloan-Kettering Cancer Center, New York, NY.
- 700 1_
- $a Radice, Paolo $u Unit of Molecular Bases of Genetic Risk and Genetic Testing, Department of Research, Fondazione IRCCS (Istituto Di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale dei Tumori (INT), Milan, Italy.
- 700 1_
- $a Ramus, Susan J $u School of Women's and Children's Health, University of New South Wales Sydney, New South Wales, Australia. The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
- 700 1_
- $a Rantala, Johanna $u Clinical Genetics, Karolinska Institutet, Stockholm, Sweden.
- 700 1_
- $a Robson, Mark $u Clinical Genetics Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY.
- 700 1_
- $a Rodriguez, Gustavo C $u Division of Gynecologic Oncology, NorthShore University HealthSystem, University of Chicago, Evanston, IL.
- 700 1_
- $a Schmutzler, Rita K $u Centers for Hereditary Breast and Ovarian Cancer, Integrated Oncology and Molecular Medicine, University Hospital of Cologne, Cologne, Germany Molecular Genetics of Breast Cancer, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 700 1_
- $a Hutten Selkirk, Christina G $u Center for Medical Genetics, NorthShore University HealthSystem, Evanston, IL.
- 700 1_
- $a Shah, Payal D $u Department of Medicine, Abramson Cancer Center, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA.
- 700 1_
- $a Simard, Jacques $u Laboratoire de génétique médicale, Nancy Université, Centre Hospitalier Régional et Universitaire, Vandoeuvre-les-Nancy, France.
- 700 1_
- $a Singer, Christian F $u Department of Obstetrics and Gynecology and Comprehensive Cancer Center, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Sokolowska, Johanna $u Genomics Center, Centre Hospitalier Universitaire de Québec Research Center, Laval University, Québec City, QC, Canada.
- 700 1_
- $a Stoppa-Lyonnet, Dominique $u Department of Tumour Biology, Institut Curie, INSERM U830, Paris, France. Université Paris Descartes, Paris, France.
- 700 1_
- $a Sutter, Christian $u Institute of Human Genetics, University Hospital Heidelberg, Heidelberg, Germany.
- 700 1_
- $a Yen Tan, Yen $u Centro de Investigación en Red de Enfermedades Raras (CIBERER), Valencia, Spain, Department of Obstetrics and Gynecology, Medical University of Vienna, Vienna, Austria.
- 700 1_
- $a Teixeira, R Manuel $u Department of Genetics, Portuguese Oncology Institute, Porto, Portugal. Biomedical Sciences Institute (ICBAS), University of Porto, Porto, Portugal.
- 700 1_
- $a Teo, Soo H $u Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia. Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
- 700 1_
- $a Terry, Mary Beth $u Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, NY.
- 700 1_
- $a Thomassen, Mads $u Department of Clinical Genetics, Odense University Hospital, Odense C, Denmark.
- 700 1_
- $a Tischkowitz, Marc $u Program in Cancer Genetics, Departments of Human Genetics and Oncology, McGill University, Montréal, QC, Canada. Department of Medical Genetics, Addenbrooke's Hospital, Cambridge, UK.
- 700 1_
- $a Toland, Amanda E $u Department of Cancer Biology and Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, OH.
- 700 1_
- $a Tucker, Katherine M $u School of Medicine, University of New South Wales, Sydney, New South Wales, Australia. Hereditary Cancer Centre, Prince of Wales Hospital, Sydney, New South Wales, Australia.
- 700 1_
- $a Tung, Nadine $u Department of Medical Oncology, Beth Israel Deaconess Medical Center, Boston, MA.
- 700 1_
- $a van Asperen, Christi J $u Department of Clinical Genetics, Leiden University Medical Center, Leiden, the Netherlands.
- 700 1_
- $a van Engelen, Klaartje $u Department of Clinical Genetics, Academic Medical Center, Amsterdam, the Netherlands.
- 700 1_
- $a van Rensburg, Elizabeth J $u Department of Genetics, University of Pretoria, Arcadia, South Africa.
- 700 1_
- $a Wang-Gohrke, Shan $u Department of Gynaecology and Obstetrics, University of Ulm, Ulm, Germany.
- 700 1_
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- 700 1_
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- 700 1_
- $a Yannoukakos, Drakoulis $u Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research 'Demokritos', Athens, Greece.
- 700 1_
- $a Greene, Mark H $u Clinical Genetics Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD.
- 700 1_
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- 700 1_
- $a Easton, Douglas F $u Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK. Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK.
- 700 1_
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- 700 1_
- $a Antoniou, Antonis C $u Department of Public Health and Primary Care, Centre for Cancer Genetic Epidemiology, University of Cambridge, Cambridge, UK.
- 700 1_
- $a Goldgar, David E $u Department of Dermatology, Huntsman Cancer Institute, University of Utah School of Medicine, Salt Lake City, UT.
- 700 1_
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- 700 1_
- $a Rebbeck, Timothy R $u Harvard T.H. Chan School of Public Health, Boston, MA. Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
- 700 1_
- $a Huo, Dezheng $u Department of Medicine, The University of Chicago, Chicago, IL. Department of Public Health Sciences, The University of Chicago, Chicago, IL (DH).
- 710 2_
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- 710 2_
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- 710 2_
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