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Mental stress and hypertension, an evolutionary framework: some historical perspectives of the 1960 World Health Organization Prague Hypertension Meeting
O. Kuchel,
Language English Country Great Britain
Document type Historical Article, Journal Article
- MeSH
- History, 20th Century MeSH
- Dopamine physiology MeSH
- Hypertension history physiopathology psychology MeSH
- Humans MeSH
- Stress, Psychological history physiopathology MeSH
- World Health Organization history MeSH
- Check Tag
- History, 20th Century MeSH
- Humans MeSH
- Publication type
- Journal Article MeSH
- Historical Article MeSH
- Geographicals
- Czech Republic MeSH
Emotional stress acutely and repetitively causing blood pressure increase or aggravating existing hypertension is usually not reflected by norepinephrine and epinephrine increase but by a sudden rise of dopamine, the third "defensive" catecholamine coping with the damaging neuropsychological and cardiovascular actions of the first two. This double-edged sympathetic response to emotional stress evolves during human lifespan and long-term evolution of hypertension. In the course of philogenesis it carries a potential mismatch between the normal physiology of the human dopaminergic system and current environmental (emotional particularly) conditions in industrialized countries. This offers a rational support to a mental stress-cardiovascular diseases relationship proposed 40 years ago in a WHO report which followed a memorable 1960 Prague Hypertension Meeting.
References provided by Crossref.org
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