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Prevalence of Helicobacter pylori in adenotonsillar hypertrophy in children
J. Kraus, E. Nártová, E. Pavlík, R. Katra, I. Sterzl, J. Astl,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
NLK
CINAHL Plus with Full Text (EBSCOhost)
from 1998-01-01 to 1 year ago
Medline Complete (EBSCOhost)
from 1998-01-01 to 1 year ago
- MeSH
- Adenoids microbiology pathology MeSH
- Antigens, Bacterial analysis MeSH
- Bacterial Proteins analysis MeSH
- Child MeSH
- Helicobacter pylori isolation & purification MeSH
- Hypertrophy microbiology MeSH
- Helicobacter Infections epidemiology MeSH
- Palatine Tonsil microbiology pathology MeSH
- Real-Time Polymerase Chain Reaction MeSH
- Humans MeSH
- Pharyngeal Diseases microbiology MeSH
- Child, Preschool MeSH
- Prevalence MeSH
- Prospective Studies MeSH
- Check Tag
- Child MeSH
- Humans MeSH
- Male MeSH
- Child, Preschool MeSH
- Female MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Geographicals
- Czech Republic MeSH
CONCLUSION: Our results encourage the notion that the pharynx could be an extragastric reservoir of Helicobacter pylori (HP). The study confirmed the presence of HP in adenotonsillar tissue in children. It could have importance in the pathophysiology of upper respiratory diseases. However, its precise role in these processes remains unclear and requires further studies. OBJECTIVE: A prospective study was carried out to evaluate the presence of HP in tonsillar and adenoid tissue in children. The study focused on real-time PCR analyzing CagA and VacA genotypes of HP strains. METHODS: A total of 37 consecutive pediatric patients with adenotonsillar hypertrophy indicated for surgery were observed in a prospective study. Adenoidectomy and/or tonsillectomy was performed in each patient; 49 specimens were taken, 32 from adenoids and 17 from tonsils. The presence of HP and its genotype were tested in all samples by real-time PCR analysis. RESULTS: Of 49 samples analyzed, 48 were positive for the presence of HP (98%), so only 1 sample was negative. While the genotype VacAs1bm2 was definitely dominant in adenoid tissue, wider distribution was observed in tonsillar tissue. Cag(+) strains represented one-fifth of all samples (21%).
References provided by Crossref.org
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