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Genoprotective activities of plant natural substances in cancer and chemopreventive strategies in the context of 3P medicine

L. Koklesova, A. Liskova, M. Samec, T. Qaradakhi, A. Zulli, K. Smejkal, K. Kajo, J. Jakubikova, P. Behzadi, M. Pec, P. Zubor, K. Biringer, TK. Kwon, D. Büsselberg, GR. Sarria, FA. Giordano, O. Golubnitschaja, P. Kubatka,

. 2020 ; 11 (2) : 261-287. [pub] 20200529

Language English Country Switzerland

Document type Journal Article, Review

Persistent link   https://www.medvik.cz/link/bmc20019125

Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.

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$a Koklesova, Lenka $u Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
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$a Severe durable changes may occur to the DNA structure caused by exogenous and endogenous risk factors initiating the process of carcinogenesis. By evidence, a large portion of malignancies have been demonstrated as being preventable. Moreover, the targeted prevention of cancer onset is possible, due to unique properties of plant bioactive compounds. Although genoprotective effects of phytochemicals have been well documented, there is an evident lack of articles which would systematically present the spectrum of anticancer effects by phytochemicals, plant extracts, and plant-derived diet applicable to stratified patient groups at the level of targeted primary (cancer development) and secondary (cancer progression and metastatic disease) prevention. Consequently, clinical implementation of knowledge accumulated in the area is still highly restricted. To stimulate coherent co-development of the dedicated plant bioactive compound investigation on one hand and comprehensive cancer preventive strategies on the other hand, the current paper highlights and deeply analyses relevant evidence available in the area. Key molecular mechanisms are presented to detail genoprotective and anticancer activities of plants and phytochemicals. Clinical implementation is discussed. Based on the presented evidence, advanced chemopreventive strategies in the context of 3P medicine are considered.
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$a Liskova, Alena $u Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
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$a Samec, Marek $u Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
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$a Qaradakhi, Tawar $u Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.
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$a Zulli, Anthony $u Institute for Health and Sport, Victoria University, Melbourne, VIC Australia.
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$a Smejkal, Karel $u Department of Natural Drugs, Faculty of Pharmacy, Masaryk University, 612 42 Brno, Czech Republic.
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$a Kajo, Karol $u Department of Pathology, St. Elisabeth Oncology Institute, 812 50 Bratislava, Slovakia. Biomedical Research Center, Slovak Academy of Sciences, 845 05 Bratislava, Slovakia.
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$a Jakubikova, Jana $u Biomedical Research Center SAS, Cancer Research Institute, Bratislava, Slovakia.
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$a Behzadi, Payam $u Department of Microbiology, College of Basic Sciences, Shahr-e-Qods Branch, Islamic Azad University, Tehran, Iran.
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$a Pec, Martin $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
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$a Biringer, Kamil $u Department of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
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$a Kwon, Taeg Kyu $u Department of Immunology and School of Medicine, Keimyung University, Dalseo-Gu, Daegu, 42601 Korea.
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$a Giordano, Frank A $u Department of Radiation Oncology, University Hospital Bonn, Rheinische Friedrich-Wilhelms-Universität Bonn, Bonn, Germany.
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$a Kubatka, Peter $u Department of Medical Biology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 03601 Martin, Slovakia.
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