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A Bird's-Eye View of Cell Sources for Cell-Based Therapies in Blood Cancers

B. Motais, S. Charvátová, M. Hrdinka, M. Šimíček, T. Jelínek, T. Ševčíková, Z. Kořístek, R. Hájek, JR. Bagó,

. 2020 ; 12 (5) : . [pub] 20200523

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20019150

Grantová podpora
No. CZ.02.1.01/0.0/0.0/17_049/0008440 Cell Coolab Ostrava - Research and Development Center for Cell Therapy in Hematology and Oncology
No. CZ.02.1.01/0.0/0.0/18_069/0010060 New Directions of Biomedical Research in the Ostrava Region
project no. IRP03_2018-2020 Institutional Development Plan of University of Ostrava, allocated by The Ministry of Education, Youth and Sports

: Hematological malignancies comprise over a hundred different types of cancers and account for around 6.5% of all cancers. Despite the significant improvements in diagnosis and treatment, many of those cancers remain incurable. In recent years, cancer cell-based therapy has become a promising approach to treat those incurable hematological malignancies with striking results in different clinical trials. The most investigated, and the one that has advanced the most, is the cell-based therapy with T lymphocytes modified with chimeric antigen receptors. Those promising initial results prepared the ground to explore other cell-based therapies to treat patients with blood cancer. In this review, we want to provide an overview of the different types of cell-based therapies in blood cancer, describing them according to the cell source.

Citace poskytuje Crossref.org

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