-
Something wrong with this record ?
Familial Creutzfeldt-Jakob disease with temporal and spatial separation of affected members
E. Mitrova, A. Lowenthal, B. Appeal,
Language English Country Netherlands
Document type Case Reports, Journal Article
PubMed
2253724
DOI
10.1007/bf00150424
Knihovny.cz E-resources
- MeSH
- Creutzfeldt-Jakob Syndrome epidemiology etiology genetics transmission MeSH
- Middle Aged MeSH
- Humans MeSH
- Cerebral Cortex pathology MeSH
- Family MeSH
- Aged MeSH
- Animals MeSH
- Check Tag
- Middle Aged MeSH
- Humans MeSH
- Male MeSH
- Aged MeSH
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Case Reports MeSH
- Geographicals
- Czechoslovakia MeSH
Familial occurrence of three definitive and two possible cases of Creutzfeldt-Jakob disease (CJD) with temporal and spatial separation in the area of focal CJD accumulation in Slovakia is reported. Incubation period is 51 and 53 years respectively, if spatial and temporal separation of affected siblings is considered, and 51 years when the time interval between the death of the affected mother and the clinical onset in the first affected child is determined. Affected children tend to die at the same time (mean difference 3.3 years) and not at the same age (mean difference 6 years). Due to separation of the affected children, a possible common exposure to CJD infection was limited to approximately seven years during their childhood. Potential endo- and exogenous risk factors and a possible mode of CJD transmission in the described family, as well as in the CJD focus, is discussed.
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20020048
- 003
- CZ-PrNML
- 005
- 20201127152638.0
- 007
- ta
- 008
- 200929s1990 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1007/BF00150424 $2 doi
- 035 __
- $a (PubMed)2253724
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Mitrova, E $u Research Institute of Preventive Medicine, Bratislava, Czecho-Slovakia.
- 245 10
- $a Familial Creutzfeldt-Jakob disease with temporal and spatial separation of affected members / $c E. Mitrova, A. Lowenthal, B. Appeal,
- 520 9_
- $a Familial occurrence of three definitive and two possible cases of Creutzfeldt-Jakob disease (CJD) with temporal and spatial separation in the area of focal CJD accumulation in Slovakia is reported. Incubation period is 51 and 53 years respectively, if spatial and temporal separation of affected siblings is considered, and 51 years when the time interval between the death of the affected mother and the clinical onset in the first affected child is determined. Affected children tend to die at the same time (mean difference 3.3 years) and not at the same age (mean difference 6 years). Due to separation of the affected children, a possible common exposure to CJD infection was limited to approximately seven years during their childhood. Potential endo- and exogenous risk factors and a possible mode of CJD transmission in the described family, as well as in the CJD focus, is discussed.
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a zvířata $7 D000818
- 650 _2
- $a mozková kůra $x patologie $7 D002540
- 650 _2
- $a Creutzfeldtova-Jakobova nemoc $x epidemiologie $x etiologie $x genetika $x přenos $7 D007562
- 650 _2
- $a rodina $7 D005190
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 651 _2
- $a Československo $x epidemiologie $7 D003604
- 655 _2
- $a kazuistiky $7 D002363
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Lowenthal, A
- 700 1_
- $a Appeal, B
- 773 0_
- $w MED00001617 $t European journal of epidemiology $x 0393-2990 $g Roč. 6, č. 3 (1990), s. 233-8
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/2253724 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20200929 $b ABA008
- 991 __
- $a 20201127152635 $b ABA008
- 999 __
- $a ok $b bmc $g 1588232 $s 1110253
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 1990 $b 6 $c 3 $d 233-8 $e - $i 0393-2990 $m European journal of epidemiology $n Eur J Epidemiol $x MED00001617
- LZP __
- $a Pubmed-20200929