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Cholesterol in the Cell Membrane-An Emerging Player in Atherogenesis
K. Paukner, I. Králová Lesná, R. Poledne
Language English Country Switzerland
Document type Journal Article, Review
Grant support
no. NU20-01-00022
Ministry of Health of the Czech Republic
NLK
Free Medical Journals
from 2000
Freely Accessible Science Journals
from 2000
PubMed Central
from 2007
Europe PubMed Central
from 2007
ProQuest Central
from 2000-03-01
Open Access Digital Library
from 2000-01-01
Open Access Digital Library
from 2007-01-01
Health & Medicine (ProQuest)
from 2000-03-01
ROAD: Directory of Open Access Scholarly Resources
from 2000
PubMed
35008955
DOI
10.3390/ijms23010533
Knihovny.cz E-resources
- MeSH
- Atherosclerosis * MeSH
- Biological Transport MeSH
- Cell Membrane chemistry metabolism MeSH
- Cholesterol chemistry metabolism MeSH
- Homeostasis MeSH
- Humans MeSH
- Lipoproteins metabolism MeSH
- Macrophages metabolism MeSH
- Membrane Microdomains chemistry metabolism MeSH
- Lipid Metabolism MeSH
- Protein Binding MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Review MeSH
Membrane cholesterol is essential for cell membrane properties, just as serum cholesterol is important for the transport of molecules between organs. This review focuses on cholesterol transport between lipoproteins and lipid rafts on the surface of macrophages. Recent studies exploring this mechanism and recognition of the central dogma-the key role of macrophages in cardiovascular disease-have led to the notion that this transport mechanism plays a major role in the pathogenesis of atherosclerosis. The exact molecular mechanism of this transport remains unclear. Future research will improve our understanding of the molecular and cellular bases of lipid raft-associated cholesterol transport.
References provided by Crossref.org
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