-
Something wrong with this record ?
Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset
T. Langer, E. Clemens, L. Broer, L. Maier, AG. Uitterlinden, ACH. de Vries, M. van Grotel, SFM. Pluijm, H. Binder, B. Mayer, A. von dem Knesebeck, J. Byrne, E. van Dulmen-den Broeder, M. Crocco, D. Grabow, P. Kaatsch, M. Kaiser, C. Spix, L....
Language English Country Netherlands
Document type Journal Article
NLK
Directory of Open Access Journals
from 2014
Free Medical Journals
from 2014-12-01
PubMed Central
from 2014
Europe PubMed Central
from 2014 to 2020
Open Access Digital Library
from 2014-12-01
Open Access Digital Library
from 2014-01-01
Open Access Digital Library
from 2014-01-01
ROAD: Directory of Open Access Scholarly Resources
from 2014
- Publication type
- Journal Article MeSH
Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (TPMT) is considered a critical gene for susceptibility to cisplatin-induced hearing loss in a pharmacogenetic guideline. The PanCareLIFE cross-sectional cohort study evaluated the genetic associations in a large pan-European population and assessed the diagnostic accuracy of the genetic markers. 1,112 pediatric cancer survivors who had provided biomaterial for genotyping were screened for participation in the pharmacogenetic association study. 900 participants qualified for inclusion. Based on the assessment of original audiograms, patients were assigned to three phenotype categories: no, minor, and clinically relevant hearing loss. Fourteen variants in eleven candidate genes (ABCC3, OTOS, TPMT, SLC22A2, NFE2L2, SLC16A5, LRP2, GSTP1, SOD2, WFS1, and ACYP2) were genotyped. The genotype and phenotype data represent a resource for conducting meta-analyses to derive a more precise pooled estimate of the effects of genes on the risk of hearing loss due to platinum treatment.
Aarhus University Hospital Department of Pediatrics Aarhus University Hospital Aarhus Denmark
Boyne Research Institute Drogheda Ireland
Danish Cancer Society Research Center Childhood Cancer Research Group Copenhagen Denmark
Department of Children Hemato Oncology Motol University Hospital Prague Prague Czech Republic
Department of Internal Medicine Erasmus Medical Center Rotterdam The Netherlands
Department of Neurooncology Istituto Giannina Gaslini Genova Italy
Department of Otolaryngology Head and Neck Surgery Inselspital University of Berne
Hospital for Children and Adolescents University of Erlangen Nuremberg Erlangen Germany
Institute for Social Medicine and Epidemiology University of Lübeck Lübeck Germany
Institute of Epidemiology and Medical Biometry University of Ulm Ulm Germany
Princess Máxima Center for Pediatric Oncology Utrecht The Netherlands
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20021766
- 003
- CZ-PrNML
- 005
- 20210209125320.0
- 007
- ta
- 008
- 201125s2020 ne f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.dib.2020.106227 $2 doi
- 035 __
- $a (PubMed)32939381
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a ne
- 100 1_
- $a Langer, Thorsten $u Department of Pediatric Oncology and Hematology, University Hospital for Children and Adolescents, Lübeck, Germany.
- 245 10
- $a Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset / $c T. Langer, E. Clemens, L. Broer, L. Maier, AG. Uitterlinden, ACH. de Vries, M. van Grotel, SFM. Pluijm, H. Binder, B. Mayer, A. von dem Knesebeck, J. Byrne, E. van Dulmen-den Broeder, M. Crocco, D. Grabow, P. Kaatsch, M. Kaiser, C. Spix, L. Kenborg, JF. Winther, C. Rechnitzer, H. Hasle, T. Kepak, AF. van der Kooi, LC. Kremer, J. Kruseova, S. Bielack, B. Sorg, S. Hecker-Nolting, CE. Kuehni, M. Ansari, M. Kompis, HJ. van der Pal, R. Parfitt, D. Deuster, P. Matulat, A. Tillmanns, WJE. Tissing, JD. Beck, S. Elsner, A. Am Zehnhoff-Dinnesen, MM. van den Heuvel-Eibrink, O. Zolk, PanCareLIFE consortium,
- 520 9_
- $a Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (TPMT) is considered a critical gene for susceptibility to cisplatin-induced hearing loss in a pharmacogenetic guideline. The PanCareLIFE cross-sectional cohort study evaluated the genetic associations in a large pan-European population and assessed the diagnostic accuracy of the genetic markers. 1,112 pediatric cancer survivors who had provided biomaterial for genotyping were screened for participation in the pharmacogenetic association study. 900 participants qualified for inclusion. Based on the assessment of original audiograms, patients were assigned to three phenotype categories: no, minor, and clinically relevant hearing loss. Fourteen variants in eleven candidate genes (ABCC3, OTOS, TPMT, SLC22A2, NFE2L2, SLC16A5, LRP2, GSTP1, SOD2, WFS1, and ACYP2) were genotyped. The genotype and phenotype data represent a resource for conducting meta-analyses to derive a more precise pooled estimate of the effects of genes on the risk of hearing loss due to platinum treatment.
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Clemens, Eva $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
- 700 1_
- $a Broer, Linda $u Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a Maier, Lara $u Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University Medical Center, Ulm, Germany.
- 700 1_
- $a Uitterlinden, André G $u Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands.
- 700 1_
- $a de Vries, Andrica C H $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
- 700 1_
- $a van Grotel, Martine $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
- 700 1_
- $a Pluijm, Saskia F M $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
- 700 1_
- $a Binder, Harald $u German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany. Institute of Medical Biometry and Statistics, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
- 700 1_
- $a Mayer, Benjamin $u Institute of Epidemiology and Medical Biometry, University of Ulm, Ulm, Germany.
- 700 1_
- $a von dem Knesebeck, Annika $u Department of Pediatric Oncology and Hematology, University Hospital for Children and Adolescents, Lübeck, Germany.
- 700 1_
- $a Byrne, Julianne $u Boyne Research Institute, Drogheda, Ireland.
- 700 1_
- $a van Dulmen-den Broeder, Eline $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Hematology and Oncology, VU Medical Center, Amsterdam, The Netherlands.
- 700 1_
- $a Crocco, Marco $u Department of Neurooncology, Istituto Giannina Gaslini, Genova, Italy.
- 700 1_
- $a Grabow, Desiree $u German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Kaatsch, Peter $u German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Kaiser, Melanie $u German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Spix, Claudia $u German Childhood Cancer Registry, Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Center of the Johannes Gutenberg University Mainz, Mainz, Germany.
- 700 1_
- $a Kenborg, Line $u Danish Cancer Society Research Center, Childhood Cancer Research Group, Copenhagen, Denmark.
- 700 1_
- $a Winther, Jeanette F $u Danish Cancer Society Research Center, Childhood Cancer Research Group, Copenhagen, Denmark. Department of Clinical Medicine, Faculty of Health, Aarhus University, Aarhus, Denmark.
- 700 1_
- $a Rechnitzer, Catherine $u Copenhagen University Hospital Rigshospitalet, Department of Pediatrics and Adolescent Medicine, Copenhagen, Denmark.
- 700 1_
- $a Hasle, Henrik $u Aarhus University Hospital, Department of Pediatrics, Aarhus University Hospital, Aarhus, Denmark.
- 700 1_
- $a Kepak, Tomas $u University Hospital Brno, Brno, Czech Republic, & International Clinical Research Center (FNUSA-ICRC), Brno, Czech Republic.
- 700 1_
- $a van der Kooi, Anne-Lotte F $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Obstetrics and Gynecology, Erasmus MC - Sophia Children's Hospital, The Netherlands.
- 700 1_
- $a Kremer, Leontien C $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Oncology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
- 700 1_
- $a Kruseova, Jarmila $u Department of Children Hemato-Oncology, Motol University Hospital Prague, Prague, Czech Republic.
- 700 1_
- $a Bielack, Stefan $u Department of Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.
- 700 1_
- $a Sorg, Benjamin $u Department of Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.
- 700 1_
- $a Hecker-Nolting, Stefanie $u Department of Pediatric Oncology, Hematology, Immunology, Stuttgart Cancer Center, Olgahospital, Stuttgart, Germany.
- 700 1_
- $a Kuehni, Claudia E $u Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland. Paediatric Oncology, Dept. of Paediatrics, Inselspital, University of Bern, Switzerland.
- 700 1_
- $a Ansari, Marc $u Department of Pediatrics, Oncology and Hematology Unit, University Hospital of Geneva, Cansearch Research Laboratory, Geneva University, Switzerland.
- 700 1_
- $a Kompis, Martin $u Department of Otolaryngology, Head and Neck Surgery, Inselspital, University of Berne.
- 700 1_
- $a van der Pal, Heleen J $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Oncology, Academic Medical Center Amsterdam, Amsterdam, The Netherlands.
- 700 1_
- $a Parfitt, Ross $u Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
- 700 1_
- $a Deuster, Dirk $u Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
- 700 1_
- $a Matulat, Peter $u Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
- 700 1_
- $a Tillmanns, Amelie $u Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
- 700 1_
- $a Tissing, Wim J E $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Oncology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
- 700 1_
- $a Beck, Jörn D $u Hospital for Children and Adolescents, University of Erlangen-Nuremberg, Erlangen, Germany.
- 700 1_
- $a Elsner, Susanne $u Institute for Social Medicine and Epidemiology, University of Lübeck, Lübeck, Germany.
- 700 1_
- $a Am Zehnhoff-Dinnesen, Antoinette $u Department of Phoniatrics and Pedaudiology, University Hospital Münster, Westphalian Wilhelm University, Münster, Germany.
- 700 1_
- $a van den Heuvel-Eibrink, Marry M $u Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. Department of Pediatric Oncology, Erasmus MC - Sophia Children's Hospital, Rotterdam, The Netherlands.
- 700 1_
- $a Zolk, Oliver $u Institute of Clinical Pharmacology, Immanuel Klinik Rüdersdorf, Brandenburg Medical School Theodor Fontane, Germany. Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University Medical Center, Ulm, Germany.
- 710 2_
- $a PanCareLIFE consortium
- 773 0_
- $w MED00188041 $t Data in brief $x 2352-3409 $g Roč. 32, č. - (2020), s. 106227
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/32939381 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20210209125314 $b ABA008
- 999 __
- $a ind $b bmc $g 1591475 $s 1112438
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2020 $b 32 $c - $d 106227 $e 20200824 $i 2352-3409 $m Data in brief $n Data Brief $x MED00188041
- LZP __
- $a Pubmed-20201125
