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Multifunctional Roles of miR-34a in Cancer: A Review with the Emphasis on Head and Neck Squamous Cell Carcinoma and Thyroid Cancer with Clinical Implications

D. Kalfert, M. Ludvikova, M. Pesta, J. Ludvik, L. Dostalova, I. Kholová,

. 2020 ; 10 (8) : . [pub] 20200805

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20021859

Grantová podpora
18-03978S Grantová Agentura České Republiky
18-08-00229 Ministerstvo Zdravotnictví Ceské Republiky
Progres Q28/LF1(UNCE 204013) Univerzita Karlova v Praze
Progres Q39 Univerzita Karlova v Praze
VTR Pirkanmaa Cancer Foundation

MiR-34a belongs to the class of small non-coding regulatory RNAs and functions as a tumor suppressor. Under physiological conditions, miR-34a has an inhibitory effect on all processes related to cell proliferation by targeting many proto-oncogenes and silencing them on the post-transcriptional level. However, deregulation of miR-34a was shown to play important roles in tumorigenesis and processes associated with cancer progression, such as tumor-associated epithelial-mesenchymal transition, invasion, and metastasis. Moreover, further understanding of miR-34a molecular mechanisms in cancer are indispensable for the development of effective diagnosis and treatments. In this review, we summarized the current knowledge on miR-34a functions in human disease with an emphasis on its regulation and dysregulation, its role in human cancer, specifically head and neck squamous carcinoma and thyroid cancer, and emerging role as a disease diagnostic and prognostic biomarker and the novel therapeutic target in oncology.

Citace poskytuje Crossref.org

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