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Intercellular Mitochondrial Transfer in the Tumor Microenvironment

H. Sahinbegovic, T. Jelinek, M. Hrdinka, JR. Bago, M. Turi, T. Sevcikova, A. Kurtovic-Kozaric, R. Hajek, M. Simicek,

. 2020 ; 12 (7) : . [pub] 20200704

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články, přehledy

Perzistentní odkaz   https://www.medvik.cz/link/bmc20022018

Grantová podpora
GA CR 19-25354Y Grantová Agentura České Republiky
project no. IRP03_2018-2020 Institutional Development Plan of University of Ostrava
No. CZ.02.1.01/0.0/0.0/16_019/0000868 ERDF-Project ENOCH
No. CZ.02.1.01/0.0/0.0/18_069/0010060 ERDF-Project New Directions of Biomedical Research in the Ostrava Region
SGS03/LF/2019-2020 and SGS03/PrF/2019-2020 University of Ostrava

Cell-to-cell communication is a fundamental process in every multicellular organism. In addition to membrane-bound and released factors, the sharing of cytosolic components represents a new, poorly explored signaling route. An extraordinary example of this communication channel is the direct transport of mitochondria between cells. In this review, we discuss how intercellular mitochondrial transfer can be used by cancer cells to sustain their high metabolic requirements and promote drug resistance and describe relevant molecular players in the context of current and future cancer therapy.

Citace poskytuje Crossref.org

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$a Cell-to-cell communication is a fundamental process in every multicellular organism. In addition to membrane-bound and released factors, the sharing of cytosolic components represents a new, poorly explored signaling route. An extraordinary example of this communication channel is the direct transport of mitochondria between cells. In this review, we discuss how intercellular mitochondrial transfer can be used by cancer cells to sustain their high metabolic requirements and promote drug resistance and describe relevant molecular players in the context of current and future cancer therapy.
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$a Bago, Juli R $u Department of Clinical Studies, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic. Department of Hematooncology, University Hospital Ostrava, 70200 Ostrava, Czech Republic.
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$a Turi, Marcello $u Department of Clinical Studies, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic. Faculty of Science, University of Ostrava, 70800 Ostrava, Czech Republic.
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$a Sevcikova, Tereza $u Department of Clinical Studies, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic. Department of Hematooncology, University Hospital Ostrava, 70200 Ostrava, Czech Republic. Faculty of Science, University of Ostrava, 70800 Ostrava, Czech Republic.
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$a Kurtovic-Kozaric, Amina $u Faculty of Genetics and Bioengineering, International Burch University, 71210 Sarajevo, Bosnia and Herzegovina.
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$a Hajek, Roman $u Department of Clinical Studies, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic. Department of Hematooncology, University Hospital Ostrava, 70200 Ostrava, Czech Republic.
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$a Simicek, Michal $u Department of Clinical Studies, Faculty of Medicine, University of Ostrava, 70300 Ostrava, Czech Republic. Department of Hematooncology, University Hospital Ostrava, 70200 Ostrava, Czech Republic. Faculty of Science, University of Ostrava, 70800 Ostrava, Czech Republic.
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