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Poly-ε-caprolactone and polyvinyl alcohol electrospun wound dressings: adhesion properties and wound management of skin defects in rabbits
M. Buzgo, M. Plencner, M. Rampichova, A. Litvinec, E. Prosecka, A. Staffa, M. Kralovic, E. Filova, M. Doupnik, V. Lukasova, K. Vocetkova, J. Anderova, T. Kubikova, R. Zajicek, F. Lopot, K. Jelen, Z. Tonar, E. Amler, R. Divin, F. Fiori,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
NV17-32285A
MZ0
CEP Register
NV17-32285A
MZ0
CEP Register
Digital library NLK
Full text - Article
Full text - Article
NLK
PubMed Central
from 2015 to 1 year ago
ProQuest Central
from 2018-01-01 to 2020-11-30
Health & Medicine (ProQuest)
from 2018-01-01 to 2020-11-30
PubMed
31180294
DOI
10.2217/rme-2018-0072
Knihovny.cz E-resources
- MeSH
- 3T3 Cells MeSH
- Wound Healing drug effects MeSH
- Rabbits MeSH
- Skin * injuries metabolism pathology MeSH
- Mice MeSH
- Nanofibers chemistry MeSH
- Bandages * MeSH
- Polyesters * chemistry pharmacology MeSH
- Polyvinyl Alcohol chemistry pharmacology MeSH
- Swine MeSH
- Tissue Adhesives * chemistry pharmacology MeSH
- Animals MeSH
- Check Tag
- Rabbits MeSH
- Mice MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Aim: This study evaluates the effect of electrospun dressings in critical sized full-thickness skin defects in rabbits. Materials & methods: Electrospun poly-ε-caprolactone (PCL) and polyvinyl alcohol (PVA) nanofibers were tested in vitro and in vivo. Results: The PCL scaffold supported the proliferation of mesenchymal stem cells, fibroblasts and keratinocytes. The PVA scaffold showed significant swelling, high elongation capacity, limited protein adsorption and stimulation of cells. Nanofibrous dressings improved wound healing compared with the control group in vivo. A change of the PCL dressing every 7 days resulted in a decreased epithelial thickness and type I collagen level in the adhesive group, indicating peeling off of the newly formed tissue. In the PVA dressings, the exchange did not affect healing. Conclusion: The results demonstrate the importance of proper dressing exchange.
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- $a Buzgo, Matej $u Department of Biophysics, 2nd Faculty of Medicine, Charles University, V Uvalu 84, 150 06 Prague 5, Czech Republic. Laboratory of Tissue Engineering, Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1083, 142 20 Prague 4, Czech Republic. Laboratory of Advanced Biomaterials, University Centre for Energy Efficient Buildings, Czech Technical University, Trinecka 1024, 273 43 Bustehrad, Czech Republic.
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