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Poly-ε-caprolactone and polyvinyl alcohol electrospun wound dressings: adhesion properties and wound management of skin defects in rabbits
M. Buzgo, M. Plencner, M. Rampichova, A. Litvinec, E. Prosecka, A. Staffa, M. Kralovic, E. Filova, M. Doupnik, V. Lukasova, K. Vocetkova, J. Anderova, T. Kubikova, R. Zajicek, F. Lopot, K. Jelen, Z. Tonar, E. Amler, R. Divin, F. Fiori,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
NV17-32285A
MZ0
CEP - Centrální evidence projektů
NV17-32285A
MZ0
CEP - Centrální evidence projektů
Digitální knihovna NLK
Plný text - Článek
Plný text - Článek
NLK
ProQuest Central
od 2018-01-01 do 2020-11-30
Health & Medicine (ProQuest)
od 2018-01-01 do 2020-11-30
PubMed
31180294
DOI
10.2217/rme-2018-0072
Knihovny.cz E-zdroje
- MeSH
- buňky 3T3 MeSH
- hojení ran účinky léků MeSH
- králíci MeSH
- kůže * zranění metabolismus patologie MeSH
- myši MeSH
- nanovlákna chemie MeSH
- obvazy * MeSH
- polyestery * chemie farmakologie MeSH
- polyvinylalkohol chemie farmakologie MeSH
- prasata MeSH
- tkáňová adheziva * chemie farmakologie MeSH
- zvířata MeSH
- Check Tag
- králíci MeSH
- myši MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
Aim: This study evaluates the effect of electrospun dressings in critical sized full-thickness skin defects in rabbits. Materials & methods: Electrospun poly-ε-caprolactone (PCL) and polyvinyl alcohol (PVA) nanofibers were tested in vitro and in vivo. Results: The PCL scaffold supported the proliferation of mesenchymal stem cells, fibroblasts and keratinocytes. The PVA scaffold showed significant swelling, high elongation capacity, limited protein adsorption and stimulation of cells. Nanofibrous dressings improved wound healing compared with the control group in vivo. A change of the PCL dressing every 7 days resulted in a decreased epithelial thickness and type I collagen level in the adhesive group, indicating peeling off of the newly formed tissue. In the PVA dressings, the exchange did not affect healing. Conclusion: The results demonstrate the importance of proper dressing exchange.
Citace poskytuje Crossref.org
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