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Immunophenotyping of Paroxysmal Nocturnal Hemoglobinuria (PNH)
AJ. Illingworth, I. Marinov, DR. Sutherland,
Language English Country United States
Document type Journal Article
- MeSH
- CD59 Antigens immunology MeSH
- Erythrocytes immunology MeSH
- Immunophenotyping methods MeSH
- Leukocytes immunology MeSH
- Humans MeSH
- Hemoglobinuria, Paroxysmal blood immunology MeSH
- Flow Cytometry methods MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
Paroxysmal nocturnal hemoglobinuria (PNH) is a rare but often debilitating disease which may lead to death in up to 35% of patients within 5 years if unrecognized and untreated. Detection of PNH and assessment of PNH clone size in RBC and WBC lineages by flow cytometric analysis has increased in importance due to the availability of novel therapies. These therapies typically block the hemolysis of red blood cells and thus significantly lower the morbidities and mortality associated with this disease. This chapter describes validated, state-of-the-art, high-sensitivity flow cytometric methodologies based on latest published testing guidelines for PNH.
Dahl Chase Diagnostic Services Bangor ME USA
Institute of Hematology and Blood Transfusion Prague 2 Czech Republic
References provided by Crossref.org
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