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PUMA - pooled uranium miners analysis: cohort profile
E. Rage, DB. Richardson, PA. Demers, M. Do, N. Fenske, M. Kreuzer, J. Samet, C. Wiggins, MK. Schubauer-Berigan, K. Kelly-Reif, L. Tomasek, LB. Zablotska, D. Laurier,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem, Research Support, U.S. Gov't, P.H.S.
NLK
ProQuest Central
od 1994-01-01 do Před 6 měsíci
Nursing & Allied Health Database (ProQuest)
od 1994-01-01 do Před 6 měsíci
Health & Medicine (ProQuest)
od 1994-01-01 do Před 6 měsíci
Public Health Database (ProQuest)
od 1994-01-01 do Před 6 měsíci
- MeSH
- hodnocení rizik MeSH
- horníci * MeSH
- kohortové studie MeSH
- kouření cigaret epidemiologie MeSH
- lidé MeSH
- nádory plic epidemiologie mortalita MeSH
- nádory vyvolané zářením epidemiologie mortalita MeSH
- nemoci z povolání epidemiologie MeSH
- pracovní expozice škodlivé účinky MeSH
- radon škodlivé účinky MeSH
- uran * MeSH
- Check Tag
- lidé MeSH
- mužské pohlaví MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
- Research Support, U.S. Gov't, P.H.S. MeSH
- Geografické názvy
- Evropa MeSH
- Severní Amerika MeSH
OBJECTIVES: Epidemiological studies of underground miners have provided clear evidence that inhalation of radon decay products causes lung cancer. Moreover, these studies have served as a quantitative basis for estimation of radon-associated excess lung cancer risk. However, questions remain regarding the effects of exposure to the low levels of radon decay products typically encountered in contemporary occupational and environmental settings on the risk of lung cancer and other diseases, and on the modifiers of these associations. These issues are of central importance for estimation of risks associated with residential and occupational radon exposures. METHODS: The Pooled Uranium Miner Analysis (PUMA) assembles information on cohorts of uranium miners in North America and Europe. Data available include individual annual estimates of exposure to radon decay products, demographic and employment history information on each worker and information on vital status, date of death and cause of death. Some, but not all, cohorts also have individual information on cigarette smoking, external gamma radiation exposure and non-radiological occupational exposures. RESULTS: The PUMA study represents the largest study of uranium miners conducted to date, encompassing 124 507 miners, 4.51 million person-years at risk and 54 462 deaths, including 7825 deaths due to lung cancer. Planned research topics include analyses of associations between radon exposure and mortality due to lung cancer, cancers other than lung, non-malignant disease, modifiers of these associations and characterisation of overall relative mortality excesses and lifetime risks. CONCLUSION: PUMA provides opportunities to evaluate new research questions and to conduct analyses to assess potential health risks associated with uranium mining that have greater statistical power than can be achieved with any single cohort.
Cancer Care Ontario Toronto Ontario Canada
Colorado School of Public Health Aurora Colorado USA
Institute for Radiological Protection and Nuclear Safety PSE SANTE SESANE Fontenay aux Roses France
National Institute for Occupational Safety and Health Cincinnati Ohio USA
National Radiation Protection Institute Prague Czech Republic
University of California San Francisco San Francisco California USA
Citace poskytuje Crossref.org
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- $a OBJECTIVES: Epidemiological studies of underground miners have provided clear evidence that inhalation of radon decay products causes lung cancer. Moreover, these studies have served as a quantitative basis for estimation of radon-associated excess lung cancer risk. However, questions remain regarding the effects of exposure to the low levels of radon decay products typically encountered in contemporary occupational and environmental settings on the risk of lung cancer and other diseases, and on the modifiers of these associations. These issues are of central importance for estimation of risks associated with residential and occupational radon exposures. METHODS: The Pooled Uranium Miner Analysis (PUMA) assembles information on cohorts of uranium miners in North America and Europe. Data available include individual annual estimates of exposure to radon decay products, demographic and employment history information on each worker and information on vital status, date of death and cause of death. Some, but not all, cohorts also have individual information on cigarette smoking, external gamma radiation exposure and non-radiological occupational exposures. RESULTS: The PUMA study represents the largest study of uranium miners conducted to date, encompassing 124 507 miners, 4.51 million person-years at risk and 54 462 deaths, including 7825 deaths due to lung cancer. Planned research topics include analyses of associations between radon exposure and mortality due to lung cancer, cancers other than lung, non-malignant disease, modifiers of these associations and characterisation of overall relative mortality excesses and lifetime risks. CONCLUSION: PUMA provides opportunities to evaluate new research questions and to conduct analyses to assess potential health risks associated with uranium mining that have greater statistical power than can be achieved with any single cohort.
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