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Characterization of p53 Family Homologs in Evolutionary Remote Branches of Holozoa

M. Bartas, V. Brázda, J. Červeň, P. Pečinka,

. 2019 ; 21 (1) : . [pub] 20191218

Jazyk angličtina Země Švýcarsko

Typ dokumentu časopisecké články

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023324

Grantová podpora
project LO1208 TEWEP Ministry of Education, Youth and Sports of the Czech Republic in the "National Feasibility Program I"
18-15548S The Czech Science Foundation
CZ.1.05/2.1.00/19.0388 EU structural funding Operational Programme Research and Development for innovation
SGS/09/PrF/2019 University of Ostrava

The p53 family of transcription factors plays key roles in development, genome stability, senescence and tumor development, and p53 is the most important tumor suppressor protein in humans. Although intensively investigated for many years, its initial evolutionary history is not yet fully elucidated. Using bioinformatic and structure prediction methods on current databases containing newly-sequenced genomes and transcriptomes, we present a detailed characterization of p53 family homologs in remote members of the Holozoa group, in the unicellular clades Filasterea, Ichthyosporea and Corallochytrea. Moreover, we show that these newly characterized homologous sequences contain domains that can form structures with high similarity to the human p53 family DNA-binding domain, and some also show similarities to the oligomerization and SAM domains. The presence of these remote homologs demonstrates an ancient origin of the p53 protein family.

Citace poskytuje Crossref.org

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