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More precise, more universal and more specific - the next generation of RNA-guided endonucleases for genome editing
M. Marzec, G. Hensel,
Jazyk angličtina Země Velká Británie
Typ dokumentu časopisecké články, práce podpořená grantem
Grantová podpora
FKZ 031B0547
German Federal Ministry of Education and Research - International
CZ.02.1.01./0.0/0.0/16_019/0000827
Czech Science Foundation - International
SPP 813103381
Czech Science Foundation - International
NLK
Free Medical Journals
od 2005 do Před 1 rokem
Medline Complete (EBSCOhost)
od 2005-01-01 do Před 1 rokem
Wiley Free Content
od 2005 do Před 1 rokem
PubMed
31612609
DOI
10.1111/febs.15079
Knihovny.cz E-zdroje
- MeSH
- DNA genetika MeSH
- editace genu * MeSH
- endonukleasy genetika metabolismus MeSH
- guide RNA, Kinetoplastida genetika MeSH
- lidé MeSH
- sekvence CRISPR genetika MeSH
- zvířata MeSH
- Check Tag
- lidé MeSH
- zvířata MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
CRISPR is a prokaryotic defence system that was adapted as a tool for genome editing and has become one of the most important discoveries of this century. CRISPR-associated endonucleases cleave DNA at precise sites, which are marked by complementary short-guided RNA. The recently developed versions of endonucleases are compatible with a broad range of PAM motifs, have a higher specificity and enable a specific nucleotide to be replaced.
Citace poskytuje Crossref.org
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