-
Je něco špatně v tomto záznamu ?
The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals
G. Salvadó, D. Ferreira, G. Operto, I. Cumplido-Mayoral, EM. Arenaza-Urquijo, R. Cacciaglia, C. Falcon, N. Vilor-Tejedor, C. Minguillon, C. Groot, WM. van der Flier, F. Barkhof, P. Scheltens, R. Ossenkoppele, S. Kern, A. Zettergren, I. Skoog, J....
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, multicentrická studie
Grantová podpora
U01 AG024904
NIA NIH HHS - United States
Department of Health - United Kingdom
PubMed
34877786
DOI
10.1002/alz.12487
Knihovny.cz E-zdroje
- MeSH
- alely MeSH
- Alzheimerova nemoc * genetika patologie MeSH
- apolipoprotein E2 * genetika MeSH
- genotyp MeSH
- genová dávka * MeSH
- kognitivní dysfunkce * genetika MeSH
- lidé MeSH
- šedá hmota patologie MeSH
- Check Tag
- lidé MeSH
- Publikační typ
- časopisecké články MeSH
- multicentrická studie MeSH
INTRODUCTION: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. METHODS: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). GM volumes of ε2 genotypic groups were compared to each other and to the reference group (APOE ε3/ε3). RESULTS: Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. APOE ε2 homozygotes, but not APOE ε2 heterozygotes, showed larger GM volumes in areas related to successful aging. DISCUSSION: In addition to the known resistance against amyloid-β deposition, the larger GM volumes in key brain regions may confer APOE ε2 homozygotes additional protection against AD-related cognitive decline.
Barcelonaβeta Brain Research Center Pasqual Maragall Foundation Barcelona Spain
Centre for Genomic Regulation The Barcelona Institute for Science and Technology Barcelona Spain
Centro de Investigación Biomédica en Red de Bioingeniería Biomateriales y Nanomedicina Madrid Spain
CIBER Fragilidad y Envejecimiento Saludable Madrid Spain
Clinical Memory Research Unit Lund University Lund Sweden
Department of Clinical Genetics ERASMUS MC Rotterdam the Netherlands
Department of Clinical Sciences Clinical Memory Research Unit Lund University Lund Sweden
Department of Radiology Mayo Clinic Rochester Minnesota USA
Diagnostic Radiology Institution for Clinical Sciences Lund University Lund Sweden
Image and Function Skåne University Hospital Lund Sweden
Institutes of Neurology and Healthcare Engineering University College London London UK
International Clinical Research Centre St Anne's University Hospital Brno Brno Czech Republic
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc22025289
- 003
- CZ-PrNML
- 005
- 20221031101311.0
- 007
- ta
- 008
- 221017s2022 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1002/alz.12487 $2 doi
- 035 __
- $a (PubMed)34877786
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Salvadó, Gemma $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $1 https://orcid.org/0000000252109230
- 245 14
- $a The protective gene dose effect of the APOE ε2 allele on gray matter volume in cognitively unimpaired individuals / $c G. Salvadó, D. Ferreira, G. Operto, I. Cumplido-Mayoral, EM. Arenaza-Urquijo, R. Cacciaglia, C. Falcon, N. Vilor-Tejedor, C. Minguillon, C. Groot, WM. van der Flier, F. Barkhof, P. Scheltens, R. Ossenkoppele, S. Kern, A. Zettergren, I. Skoog, J. Hort, E. Stomrud, D. van Westen, O. Hansson, JL. Molinuevo, LO. Wahlund, E. Westman, JD. Gispert, ALFA study†, BioFINDER, ADNI
- 520 9_
- $a INTRODUCTION: Harboring two copies of the apolipoprotein E (APOE) ε2 allele strongly protects against Alzheimer's disease (AD). However, the effect of this genotype on gray matter (GM) volume in cognitively unimpaired individuals has not yet been described. METHODS: Multicenter brain magnetic resonance images (MRIs) from cognitively unimpaired ε2 homozygotes were matched (1:1) against all other APOE genotypes for relevant confounders (n = 223). GM volumes of ε2 genotypic groups were compared to each other and to the reference group (APOE ε3/ε3). RESULTS: Carrying at least one ε2 allele was associated with larger GM volumes in brain areas typically affected by AD and also in areas associated with cognitive resilience. APOE ε2 homozygotes, but not APOE ε2 heterozygotes, showed larger GM volumes in areas related to successful aging. DISCUSSION: In addition to the known resistance against amyloid-β deposition, the larger GM volumes in key brain regions may confer APOE ε2 homozygotes additional protection against AD-related cognitive decline.
- 650 _2
- $a alely $7 D000483
- 650 12
- $a Alzheimerova nemoc $x genetika $x patologie $7 D000544
- 650 12
- $a apolipoprotein E2 $x genetika $7 D053329
- 650 12
- $a kognitivní dysfunkce $x genetika $7 D060825
- 650 12
- $a genová dávka $7 D018628
- 650 _2
- $a genotyp $7 D005838
- 650 _2
- $a šedá hmota $x patologie $7 D066128
- 650 _2
- $a lidé $7 D006801
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a multicentrická studie $7 D016448
- 700 1_
- $a Ferreira, Daniel $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden $u Department of Radiology, Mayo Clinic, Rochester, Minnesota, USA $1 https://orcid.org/0000000195224338
- 700 1_
- $a Operto, Grégory $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $u CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain $1 https://orcid.org/0000000202081671
- 700 1_
- $a Cumplido-Mayoral, Irene $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $1 https://orcid.org/0000000219677025
- 700 1_
- $a Arenaza-Urquijo, Eider M $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $u CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain $1 https://orcid.org/0000000170167576
- 700 1_
- $a Cacciaglia, Raffaele $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $u CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain $1 https://orcid.org/000000029216949X
- 700 1_
- $a Falcon, Carles $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $u Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain $1 https://orcid.org/0000000155642025
- 700 1_
- $a Vilor-Tejedor, Natàlia $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $u Centre for Genomic Regulation (CRG), The Barcelona Institute for Science and Technology, Barcelona, Spain $u Department of Clinical Genetics, ERASMUS MC, Rotterdam, the Netherlands $1 https://orcid.org/0000000349356721
- 700 1_
- $a Minguillon, Carolina $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $u CIBER Fragilidad y Envejecimiento Saludable (CIBERFES), Madrid, Spain $1 https://orcid.org/0000000227826908
- 700 1_
- $a Groot, Colin $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $1 https://orcid.org/0000000258026946
- 700 1_
- $a van der Flier, Wiesje M $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Department of Epidemiology & Biostatistics, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $1 https://orcid.org/0000000187666224
- 700 1_
- $a Barkhof, Frederik $u Department of Radiology and Nuclear Medicine, VU Medical Center, Neuroscience Campus Amsterdam, Amsterdam, the Netherlands $u Institutes of Neurology & Healthcare Engineering, University College London, London, UK $1 https://orcid.org/0000000335433706
- 700 1_
- $a Scheltens, Philip $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $1 https://orcid.org/0000000210466408
- 700 1_
- $a Ossenkoppele, Rik $u Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, the Netherlands $u Clinical Memory Research Unit, Lund University, Lund, Sweden $1 https://orcid.org/0000000315847477
- 700 1_
- $a Kern, Silke $u Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden
- 700 1_
- $a Zettergren, Anna $u Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden
- 700 1_
- $a Skoog, Ingmar $u Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden $1 https://orcid.org/0000000298033438
- 700 1_
- $a Hort, Jakub $u International Clinical Research Centre, St. Anne's University Hospital Brno, Brno, Czech Republic $u Memory Clinic, Department of Neurology, Charles University, 2nd Faculty of Medicine and Motol University Hospital, Prague, Czech Republic
- 700 1_
- $a Stomrud, Erik $u Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden $u Memory Clinic, Skåne University Hospital, Malmö, Sweden $1 https://orcid.org/0000000208415580
- 700 1_
- $a van Westen, Danielle $u Diagnostic Radiology, Institution for Clinical Sciences, Lund University, Lund, Sweden $u Image and Function, Skåne University Hospital, Lund, Sweden $1 https://orcid.org/0000000186499874
- 700 1_
- $a Hansson, Oskar $u Department of Clinical Sciences, Clinical Memory Research Unit, Lund University, Lund, Sweden $u Memory Clinic, Skåne University Hospital, Malmö, Sweden $1 https://orcid.org/0000000184677286
- 700 1_
- $a Molinuevo, José Luis $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $1 https://orcid.org/0000000304856001
- 700 1_
- $a Wahlund, Lars-Olof $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden $1 https://orcid.org/0000000299058426
- 700 1_
- $a Westman, Eric $u Division of Clinical Geriatrics, Center for Alzheimer Research, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden $u Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK $1 https://orcid.org/0000000231152977
- 700 1_
- $a Gispert, Juan Domingo $u Barcelonaβeta Brain Research Center (BBRC), Pasqual Maragall Foundation, Barcelona, Spain $u IMIM (Hospital del Mar Medical Research Institute), Barcelona, Spain $u Universitat Pompeu Fabra, Barcelona, Spain $u Centro de Investigación Biomédica en Red de Bioingeniería, Biomateriales y Nanomedicina (CIBER-BBN), Madrid, Spain $1 https://orcid.org/0000000261550642
- 710 2_
- $a ALFA study†, BioFINDER, ADNI
- 773 0_
- $w MED00166531 $t Alzheimer's & dementia $x 1552-5279 $g Roč. 18, č. 7 (2022), s. 1383-1395
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/34877786 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y p $z 0
- 990 __
- $a 20221017 $b ABA008
- 991 __
- $a 20221031101308 $b ABA008
- 999 __
- $a ok $b bmc $g 1854809 $s 1176579
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2022 $b 18 $c 7 $d 1383-1395 $e 20211208 $i 1552-5279 $m Alzheimer's & dementia $n Alzheimers Dement $x MED00166531
- GRA __
- $a U01 AG024904 $p NIA NIH HHS $2 United States
- GRA __
- $p Department of Health $2 United Kingdom
- LZP __
- $a Pubmed-20221017
