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More precise, more universal and more specific - the next generation of RNA-guided endonucleases for genome editing
M. Marzec, G. Hensel,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
Grant support
FKZ 031B0547
German Federal Ministry of Education and Research - International
CZ.02.1.01./0.0/0.0/16_019/0000827
Czech Science Foundation - International
SPP 813103381
Czech Science Foundation - International
NLK
Free Medical Journals
from 2005 to 1 year ago
Medline Complete (EBSCOhost)
from 2005-01-01 to 1 year ago
Wiley Free Content
from 2005 to 1 year ago
PubMed
31612609
DOI
10.1111/febs.15079
Knihovny.cz E-resources
- MeSH
- DNA genetics MeSH
- Gene Editing * MeSH
- Endonucleases genetics metabolism MeSH
- RNA, Guide, Kinetoplastida genetics MeSH
- Humans MeSH
- Clustered Regularly Interspaced Short Palindromic Repeats genetics MeSH
- Animals MeSH
- Check Tag
- Humans MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
CRISPR is a prokaryotic defence system that was adapted as a tool for genome editing and has become one of the most important discoveries of this century. CRISPR-associated endonucleases cleave DNA at precise sites, which are marked by complementary short-guided RNA. The recently developed versions of endonucleases are compatible with a broad range of PAM motifs, have a higher specificity and enable a specific nucleotide to be replaced.
References provided by Crossref.org
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