• Something wrong with this record ?

Deltaretroviruses have circulated since at least the Paleogene and infected a broad range of mammalian species

T. Hron, D. Elleder, RJ. Gifford,

. 2019 ; 16 (1) : 33. [pub] 20191127

Language English Country Great Britain

Document type Journal Article, Research Support, Non-U.S. Gov't

Persistent link   https://www.medvik.cz/link/bmc20023463

Grant support
MC_UU_12014/12 Medical Research Council - United Kingdom

The Deltaretrovirus genus of retroviruses (family Retroviridae) includes the human T cell leukemia viruses and bovine leukemia virus (BLV). Relatively little is known about the biology and evolution of these viruses, because only a few species have been identified and the genomic 'fossil record' is relatively sparse. Here, we report the discovery of multiple novel endogenous retroviruses (ERVs) derived from ancestral deltaretroviruses. These sequences-two of which contain complete or near complete internal coding regions-reside in genomes of several distinct mammalian orders, including bats, carnivores, cetaceans, and insectivores. We demonstrate that two of these ERVs contain unambiguous homologs of the tax gene, indicating that complex gene regulation has ancient origins within the Deltaretrovirus genus. ERVs demonstrate that the host range of the deltaretrovirus genus is much more extensive than suggested by the relatively small number of exogenous deltaretroviruses described so far, and allow the evolutionary timeline of deltaretrovirus-mammal interaction to be more accurately calibrated.

References provided by Crossref.org

000      
00000naa a2200000 a 4500
001      
bmc20023463
003      
CZ-PrNML
005      
20201214130114.0
007      
ta
008      
201125s2019 xxk f 000 0|eng||
009      
AR
024    7_
$a 10.1186/s12977-019-0495-9 $2 doi
035    __
$a (PubMed)31775783
040    __
$a ABA008 $b cze $d ABA008 $e AACR2
041    0_
$a eng
044    __
$a xxk
100    1_
$a Hron, Tomáš $u Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
245    10
$a Deltaretroviruses have circulated since at least the Paleogene and infected a broad range of mammalian species / $c T. Hron, D. Elleder, RJ. Gifford,
520    9_
$a The Deltaretrovirus genus of retroviruses (family Retroviridae) includes the human T cell leukemia viruses and bovine leukemia virus (BLV). Relatively little is known about the biology and evolution of these viruses, because only a few species have been identified and the genomic 'fossil record' is relatively sparse. Here, we report the discovery of multiple novel endogenous retroviruses (ERVs) derived from ancestral deltaretroviruses. These sequences-two of which contain complete or near complete internal coding regions-reside in genomes of several distinct mammalian orders, including bats, carnivores, cetaceans, and insectivores. We demonstrate that two of these ERVs contain unambiguous homologs of the tax gene, indicating that complex gene regulation has ancient origins within the Deltaretrovirus genus. ERVs demonstrate that the host range of the deltaretrovirus genus is much more extensive than suggested by the relatively small number of exogenous deltaretroviruses described so far, and allow the evolutionary timeline of deltaretrovirus-mammal interaction to be more accurately calibrated.
650    _2
$a zvířata $7 D000818
650    _2
$a Deltaretrovirus $x genetika $7 D017977
650    _2
$a endogenní retroviry $x genetika $x izolace a purifikace $7 D020077
650    12
$a molekulární evoluce $7 D019143
650    _2
$a geny pX $7 D016355
650    _2
$a genom virový $7 D016679
650    12
$a hostitelská specificita $7 D058507
650    _2
$a lidé $7 D006801
650    _2
$a savci $x virologie $7 D008322
650    _2
$a paleontologie $7 D010163
650    _2
$a fylogeneze $7 D010802
655    _2
$a časopisecké články $7 D016428
655    _2
$a práce podpořená grantem $7 D013485
700    1_
$a Elleder, Daniel $u Institute of Molecular Genetics of the Czech Academy of Sciences, Prague, Czech Republic.
700    1_
$a Gifford, Robert J $u MRC-University of Glasgow Centre for Virus Research, 464 Bearsden Rd, Bearsden, Glasgow, G61 1QH, UK. robert.gifford@glasgow.ac.uk.
773    0_
$w MED00008308 $t Retrovirology $x 1742-4690 $g Roč. 16, č. 1 (2019), s. 33
856    41
$u https://pubmed.ncbi.nlm.nih.gov/31775783 $y Pubmed
910    __
$a ABA008 $b sig $c sign $y a $z 0
990    __
$a 20201125 $b ABA008
991    __
$a 20201214130113 $b ABA008
999    __
$a ok $b bmc $g 1595782 $s 1114139
BAS    __
$a 3
BAS    __
$a PreBMC
BMC    __
$a 2019 $b 16 $c 1 $d 33 $e 20191127 $i 1742-4690 $m Retrovirology $n Retrovirology $x MED00008308
GRA    __
$a MC_UU_12014/12 $p Medical Research Council $2 United Kingdom
LZP    __
$a Pubmed-20201125

Find record

Citation metrics

Archiving options