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Staging of Schizophrenia With the Use of PANSS: An International Multi-Center Study

KN. Fountoulakis, E. Dragioti, AT. Theofilidis, T. Wikilund, X. Atmatzidis, I. Nimatoudis, E. Thys, M. Wampers, L. Hranov, T. Hristova, D. Aptalidis, R. Milev, F. Iftene, F. Spaniel, P. Knytl, P. Furstova, T. From, H. Karlsson, M. Walta, RKR....

. 2019 ; 22 (11) : 681-697. [pub] 20191101

Jazyk angličtina Země Velká Británie

Typ dokumentu časopisecké články, multicentrická studie, práce podpořená grantem

Perzistentní odkaz   https://www.medvik.cz/link/bmc20023528

INTRODUCTION: A specific clinically relevant staging model for schizophrenia has not yet been developed. The aim of the current study was to evaluate the factor structure of the PANSS and develop such a staging method. METHODS: Twenty-nine centers from 25 countries contributed 2358 patients aged 37.21 ± 11.87 years with schizophrenia. Analysis of covariance, Exploratory Factor Analysis, Discriminant Function Analysis, and inspection of resultant plots were performed. RESULTS: Exploratory Factor Analysis returned 5 factors explaining 59% of the variance (positive, negative, excitement/hostility, depression/anxiety, and neurocognition). The staging model included 4 main stages with substages that were predominantly characterized by a single domain of symptoms (stage 1: positive; stages 2a and 2b: excitement/hostility; stage 3a and 3b: depression/anxiety; stage 4a and 4b: neurocognition). There were no differences between sexes. The Discriminant Function Analysis developed an algorithm that correctly classified >85% of patients. DISCUSSION: This study elaborates a 5-factor solution and a clinical staging method for patients with schizophrenia. It is the largest study to address these issues among patients who are more likely to remain affiliated with mental health services for prolonged periods of time.

1st Department of Psychiatry Faculty of Medicine School of Health Sciences Aristotle University of Thessaloniki Greece

2nd Department of Psychiatry National and Kapodistrian University of Athens Athens Greece

3rd Department of Psychiatry Faculty of Medicine School of Health Sciences Aristotle University of Thessaloniki Greece

Clinic of Psychiatric Faculty of Medicine Vilnius University Vilnius Lithuania Psychosocial Rehabilitation Department of the Vilnius Mental Health Center Department for Psychosis Treatment of the Vilnius Mental Health Center Vilnius Lithuania

Clinical Department of Psychiatry Clinical Centre of Montenegro Podgorica Montenegro Department of Psychiatry School of Medicine University of Montenegro Dzona Dzeksona bb Podgorica Montenegro Clinical Department of Neurology Clinical Centre of Montenegro Dzona Dzeksona bb Podgorica Montenegro

Deakin University IMPACT Strategic Research Centre School of Medicine Barwon Health Geelong Australia Orygen The National Centre of Excellence in Youth Mental Health and the Centre for Youth Mental Health the Florey Institute for Neuroscience and Mental Health and the Department of Psychiatry University of Melbourne Parkville Australia

Deakin University School of Medicine IMPACT Strategic Research Centre Barwon Health Geelong Australia

Department of Adult Psychiatry Poznan University of Medical Sciences Poznan Poland

Department of Medical and Health Sciences Faculty of Health Sciences Linköping University Linköping Sweden Hallunda Psychiatric Outpatient Clinic Stockholm Psychiatric Southwest Clinic Karolinska Huddinge University Hospital Sweden

Department of Neurosciences Mental Health and Sensory Organs Suicide Prevention Center Sant'Andrea Hospital Sapienza University of Rome Rome Italy

Department of Psychiatry and Mental Health Santa Maria University Hospital Lisbon Portugal

Department of Psychiatry and Mental Health University of Cape Town Cape Town Western Cape South Africa

Department of Psychiatry and Narcology Riga Stradins University Riga Latvia

Department of Psychiatry and Psychotherapy Medical University of Vienna Vienna Austria

Department of Psychiatry and Psychotherapy Semmelweis University Budapest Hungary

Department of Psychiatry College of Medicine University of Ibadan Nigeria

Department of Psychiatry Lokmanya Tilak Municipal Medical College Mumbai India

Department of Psychiatry National and Kapodistrian University of Athens School of Medicine Eginition Hospital Athens Greece

Department of Psychiatry Queen's University Providence Care Hospital Kingston Ontario Canada

Department of Psychiatry Royal College of Surgeons in Ireland Beaumont Hospital Dublin Ireland

Department of Psychiatry Ruhr University Bochum LWL University Hospital Bochum Germany

Department of Psychiatry Sainte Marguerite University Hospital Marseille France Timone Institute of Neuroscience CNRS and Aix Marseille University Marseille France

Department of Psychiatry University of Florida *** FL

Department of Psychiatry University of Oviedo and Centro de Investigación Biomédica en Red de Salud Mental Oviedo Spain

Department of Psychiatry University of Turku Turku Finland

Institute of Mental Health Belgrade Serbia Serbian Academy of Sciences and Arts Belgrade Serbia

Institute of Mental Health School of Medicine University of Belgrade Belgrade Serbia

Molecular and Cellular Therapeutics Royal College of Surgeons in Ireland Dublin Ireland

MRC Unit on Risk and Resilience in Mental Disorders Department of Psychiatry and Mental Health University of Cape Town Cape Town South Africa

National Institute of Mental Health Klecany Czech Republic

Nyírő Gyula Hospital Budapest Hungary

Psychiatry Department Diskapi Yildirim Beyazit Training and Research Hospital Ankara Turkey

Samara State Medical University Department of Psychiatry Samara Psychiatric Hospital Inpatient Unit Russia

University Multiprofile Hospital for Active Treatment in Neurology and Psychiatry Sveti Naum Sofia Bulgaria

University of Medicine and Pharmacy of Târgu Mures Romania

University of Medicine and Pharmacy of Timisoara Romania

University Psychiatric Centre KU Leuven Kortenberg and Department of Neurosciences KU Leuven Belgium

Western University London Ontario Canada

Citace poskytuje Crossref.org

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700    1_
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