-
Something wrong with this record ?
Lifestyle and dietary environmental factors in colorectal cancer susceptibility
N. Murphy, V. Moreno, DJ. Hughes, L. Vodicka, P. Vodicka, EK. Aglago, MJ. Gunter, M. Jenab,
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't, Review
Grant support
NV15-27580A
MZ0
CEP Register
- MeSH
- Diet * MeSH
- Genetic Predisposition to Disease MeSH
- Risk Assessment MeSH
- Gene-Environment Interaction MeSH
- Host-Pathogen Interactions MeSH
- Colorectal Neoplasms epidemiology etiology MeSH
- Prescription Drugs adverse effects MeSH
- Humans MeSH
- Disease Susceptibility * MeSH
- Obesity complications metabolism MeSH
- Risk Factors MeSH
- Environment * MeSH
- Life Style * MeSH
- Check Tag
- Humans MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
- Review MeSH
Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particularly lifestyle and diet. It is established that physical inactivity, obesity and some dietary factors (red/processed meats, alcohol) are positively associated with CRC, while healthy lifestyle habits show inverse associations. Mechanistic evidence shows that lifestyle and dietary components that contribute to energy excess are linked with increased CRC via metabolic dysfunction, inflammation, oxidative stress, bacterial dysbiosis and breakdown of gut barrier integrity while the reverse is apparent for components associated with decreased risk. This chapter will review the available evidence on lifestyle and dietary factors in CRC etiology and their underlying mechanisms in CRC development. This short review will also touch upon available information on potential gene-environment interactions, molecular sub-types of CRC and anatomical sub-sites within the colorectum.
Biomedical Center Faculty of Medicine in Pilsen Charles University Pilsen Czech Republic
Consortium for Biomedical Research in Epidemiology and Public Health Spain
Department of Clinical Sciences Faculty of Medicine University of Barcelona Barcelona Spain
References provided by Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20023647
- 003
- CZ-PrNML
- 005
- 20201214130717.0
- 007
- ta
- 008
- 201125s2019 xxk f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1016/j.mam.2019.06.005 $2 doi
- 035 __
- $a (PubMed)31233770
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxk
- 100 1_
- $a Murphy, Neil $u International Agency for Research on Cancer (IARC-WHO), Lyon, France.
- 245 10
- $a Lifestyle and dietary environmental factors in colorectal cancer susceptibility / $c N. Murphy, V. Moreno, DJ. Hughes, L. Vodicka, P. Vodicka, EK. Aglago, MJ. Gunter, M. Jenab,
- 520 9_
- $a Colorectal cancer (CRC) incidence changes with time and by variations in diet and lifestyle, as evidenced historically by migrant studies and recently by extensive epidemiologic evidence. The worldwide heterogeneity in CRC incidence is strongly suggestive of etiological involvement of environmental exposures, particularly lifestyle and diet. It is established that physical inactivity, obesity and some dietary factors (red/processed meats, alcohol) are positively associated with CRC, while healthy lifestyle habits show inverse associations. Mechanistic evidence shows that lifestyle and dietary components that contribute to energy excess are linked with increased CRC via metabolic dysfunction, inflammation, oxidative stress, bacterial dysbiosis and breakdown of gut barrier integrity while the reverse is apparent for components associated with decreased risk. This chapter will review the available evidence on lifestyle and dietary factors in CRC etiology and their underlying mechanisms in CRC development. This short review will also touch upon available information on potential gene-environment interactions, molecular sub-types of CRC and anatomical sub-sites within the colorectum.
- 650 _2
- $a kolorektální nádory $x epidemiologie $x etiologie $7 D015179
- 650 12
- $a dieta $7 D004032
- 650 12
- $a náchylnost k nemoci $7 D004198
- 650 12
- $a životní prostředí $7 D004777
- 650 _2
- $a interakce genů a prostředí $7 D059647
- 650 _2
- $a genetická predispozice k nemoci $7 D020022
- 650 _2
- $a interakce hostitele a patogenu $7 D054884
- 650 _2
- $a lidé $7 D006801
- 650 12
- $a životní styl $7 D008019
- 650 _2
- $a obezita $x komplikace $x metabolismus $7 D009765
- 650 _2
- $a léky na předpis $x škodlivé účinky $7 D055553
- 650 _2
- $a hodnocení rizik $7 D018570
- 650 _2
- $a rizikové faktory $7 D012307
- 655 _2
- $a časopisecké články $7 D016428
- 655 _2
- $a práce podpořená grantem $7 D013485
- 655 _2
- $a přehledy $7 D016454
- 700 1_
- $a Moreno, Victor $u Unit of Biomarkers and Susceptibility, Oncology Data Analytics Program, Catalan Institute of Oncology (ICO). Hospitalet de Llobregat, Barcelona, Spain; Colorectal Cancer Group, ONCOBELL Program, Bellvitge Biomedical Research Institute (IDIBELL). Hospitalet de Llobregat, Barcelona, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain; Department of Clinical Sciences, Faculty of Medicine, University of Barcelona, Barcelona, Spain.
- 700 1_
- $a Hughes, David J $u Cancer Biology and Therapeutics Group, School of Biomolecular and Biomedical Science, UCD Conway Institute, University College Dublin, Dublin, Ireland.
- 700 1_
- $a Vodicka, Ludmila $u Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Vodicka, Pavel $u Department of the Molecular Biology of Cancer, Institute of Experimental Medicine, Czech Academy of Sciences, Prague, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine, Charles University, Prague, Czech Republic; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
- 700 1_
- $a Aglago, Elom K $u International Agency for Research on Cancer (IARC-WHO), Lyon, France.
- 700 1_
- $a Gunter, Marc J $u International Agency for Research on Cancer (IARC-WHO), Lyon, France.
- 700 1_
- $a Jenab, Mazda $u International Agency for Research on Cancer (IARC-WHO), Lyon, France. Electronic address: Jenabm@iarc.fr.
- 773 0_
- $w MED00003389 $t Molecular aspects of medicine $x 1872-9452 $g Roč. 69, č. - (2019), s. 2-9
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31233770 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201214130716 $b ABA008
- 999 __
- $a ok $b bmc $g 1595966 $s 1114323
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 69 $c - $d 2-9 $e 20190628 $i 1872-9452 $m Molecular aspects of medicine $n Mol Aspects Med $x MED00003389
- GRA __
- $a NV15-27580A $p MZ0
- LZP __
- $a Pubmed-20201125
