-
Je něco špatně v tomto záznamu ?
Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands
F. Haller, A. Skálová, S. Ihrler, B. Märkl, M. Bieg, EA. Moskalev, R. Erber, S. Blank, C. Winkelmann, S. Hebele, M. Baněčková, S. Wiemann, S. Müller, J. Zenk, R. Eils, H. Iro, A. Hartmann, A. Agaimy,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články
- MeSH
- acinární karcinom diagnóza MeSH
- diferenciální diagnóza MeSH
- DNA vazebné proteiny analýza biosyntéza MeSH
- dospělí MeSH
- imunohistochemie MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- nádorové biomarkery analýza MeSH
- nádory slinných žláz diagnóza MeSH
- receptory thyreoidních hormonů analýza biosyntéza MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- senzitivita a specificita MeSH
- steroidní receptory analýza biosyntéza MeSH
- Check Tag
- dospělí MeSH
- lidé středního věku MeSH
- lidé MeSH
- mladý dospělý MeSH
- mužské pohlaví MeSH
- senioři nad 80 let MeSH
- senioři MeSH
- ženské pohlaví MeSH
- Publikační typ
- časopisecké články MeSH
Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. In the current study, we evaluated the usefulness of NR4A3 immunostaining and NR4A3 fluorescence in situ hybridization (FISH) in the differential diagnosis of AciCC, comparing a total of 64 AciCCs including 17% cases with high-grade transformation, 29 secretory (mammary analog) carcinomas (MASC), and 70 other salivary gland carcinomas. Nuclear NR4A3 immunostaining was a highly specific (100%) and sensitive (98%) marker for AciCC with only 1 negative case, whereas NR4A3 FISH was less sensitive (84%). None of the MASCs or other salivary gland carcinomas displayed any nuclear NR4A3 immunostaining. The recently described HTN3-MSANTD3 gene fusion was observed in 4 of 49 (8%) evaluable AciCCs, all with nuclear NR4A3 immunostaining. In summary, NR4A3 immunostaining is a highly specific and sensitive marker for AciCC, which may be especially valuable in cases with high-grade transformation and in "zymogen granule"-poor examples within the differential diagnostic spectrum of AciCC and MASC.
Center for Digital Health Berlin Institute of Health and Charité Universitätsmedizin Berlin Berlin
Department of Otorhinolaryngology Head and Neck Surgery Augsburg Clinic Center Augsburg
Department of Pathology Charles University Faculty of Medicine in Plzen Plzen Czech Republic
Division of Molecular Genome Analysis German Cancer Research Center Heidelberg Germany
Citace poskytuje Crossref.org
- 000
- 00000naa a2200000 a 4500
- 001
- bmc20023684
- 003
- CZ-PrNML
- 005
- 20201214130826.0
- 007
- ta
- 008
- 201125s2019 xxu f 000 0|eng||
- 009
- AR
- 024 7_
- $a 10.1097/PAS.0000000000001279 $2 doi
- 035 __
- $a (PubMed)31094928
- 040 __
- $a ABA008 $b cze $d ABA008 $e AACR2
- 041 0_
- $a eng
- 044 __
- $a xxu
- 100 1_
- $a Haller, Florian $u Institute of Pathology.
- 245 10
- $a Nuclear NR4A3 Immunostaining Is a Specific and Sensitive Novel Marker for Acinic Cell Carcinoma of the Salivary Glands / $c F. Haller, A. Skálová, S. Ihrler, B. Märkl, M. Bieg, EA. Moskalev, R. Erber, S. Blank, C. Winkelmann, S. Hebele, M. Baněčková, S. Wiemann, S. Müller, J. Zenk, R. Eils, H. Iro, A. Hartmann, A. Agaimy,
- 520 9_
- $a Recently, we discovered the recurrent genomic rearrangement [t(4;9)(q13;q31)] enabling upregulation of the transcription factor Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3) through enhancer hijacking as the oncogenic driver event in acinic cell carcinoma (AciCC) of the salivary glands. In the current study, we evaluated the usefulness of NR4A3 immunostaining and NR4A3 fluorescence in situ hybridization (FISH) in the differential diagnosis of AciCC, comparing a total of 64 AciCCs including 17% cases with high-grade transformation, 29 secretory (mammary analog) carcinomas (MASC), and 70 other salivary gland carcinomas. Nuclear NR4A3 immunostaining was a highly specific (100%) and sensitive (98%) marker for AciCC with only 1 negative case, whereas NR4A3 FISH was less sensitive (84%). None of the MASCs or other salivary gland carcinomas displayed any nuclear NR4A3 immunostaining. The recently described HTN3-MSANTD3 gene fusion was observed in 4 of 49 (8%) evaluable AciCCs, all with nuclear NR4A3 immunostaining. In summary, NR4A3 immunostaining is a highly specific and sensitive marker for AciCC, which may be especially valuable in cases with high-grade transformation and in "zymogen granule"-poor examples within the differential diagnostic spectrum of AciCC and MASC.
- 650 _2
- $a dospělí $7 D000328
- 650 _2
- $a senioři $7 D000368
- 650 _2
- $a senioři nad 80 let $7 D000369
- 650 _2
- $a nádorové biomarkery $x analýza $7 D014408
- 650 _2
- $a acinární karcinom $x diagnóza $7 D018267
- 650 _2
- $a DNA vazebné proteiny $x analýza $x biosyntéza $7 D004268
- 650 _2
- $a diferenciální diagnóza $7 D003937
- 650 _2
- $a ženské pohlaví $7 D005260
- 650 _2
- $a lidé $7 D006801
- 650 _2
- $a imunohistochemie $7 D007150
- 650 _2
- $a mužské pohlaví $7 D008297
- 650 _2
- $a lidé středního věku $7 D008875
- 650 _2
- $a steroidní receptory $x analýza $x biosyntéza $7 D011987
- 650 _2
- $a receptory thyreoidních hormonů $x analýza $x biosyntéza $7 D011988
- 650 _2
- $a nádory slinných žláz $x diagnóza $7 D012468
- 650 _2
- $a senzitivita a specificita $7 D012680
- 650 _2
- $a mladý dospělý $7 D055815
- 655 _2
- $a časopisecké články $7 D016428
- 700 1_
- $a Skálová, Alena $u Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech Republic.
- 700 1_
- $a Ihrler, Stephan $u Dermpath Munich, Munich.
- 700 1_
- $a Märkl, Bruno $u Institute of Pathology, Klinikum Augsburg.
- 700 1_
- $a Bieg, Matthias $u Center for Digital Health, Berlin Institute of Health and Charité-Universitätsmedizin Berlin, Berlin.
- 700 1_
- $a Moskalev, Evgeny A $u Institute of Pathology.
- 700 1_
- $a Erber, Ramona $u Institute of Pathology.
- 700 1_
- $a Blank, Susanne $u Institute of Pathology.
- 700 1_
- $a Winkelmann, Christa $u Institute of Pathology.
- 700 1_
- $a Hebele, Simone $u Institute of Pathology.
- 700 1_
- $a Baněčková, Martina $u Department of Pathology, Charles University, Faculty of Medicine in Plzen, Plzen, Czech Republic.
- 700 1_
- $a Wiemann, Stefan $u Division of Molecular Genome Analysis, German Cancer Research Center (DKFZ), Heidelberg, Germany.
- 700 1_
- $a Müller, Sarina $u Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen.
- 700 1_
- $a Zenk, Johannes $u Department of Otorhinolaryngology, Head and Neck Surgery, Augsburg Clinic Center, Augsburg.
- 700 1_
- $a Eils, Roland $u Center for Digital Health, Berlin Institute of Health and Charité-Universitätsmedizin Berlin, Berlin.
- 700 1_
- $a Iro, Heinrich $u Department of Otorhinolaryngology, Head & Neck Surgery, University Hospital Erlangen, Friedrich-Alexander University Erlangen-Nuremberg, Erlangen.
- 700 1_
- $a Hartmann, Arndt $u Institute of Pathology.
- 700 1_
- $a Agaimy, Abbas $u Institute of Pathology.
- 773 0_
- $w MED00000304 $t The American journal of surgical pathology $x 1532-0979 $g Roč. 43, č. 9 (2019), s. 1264-1272
- 856 41
- $u https://pubmed.ncbi.nlm.nih.gov/31094928 $y Pubmed
- 910 __
- $a ABA008 $b sig $c sign $y a $z 0
- 990 __
- $a 20201125 $b ABA008
- 991 __
- $a 20201214130825 $b ABA008
- 999 __
- $a ok $b bmc $g 1596003 $s 1114360
- BAS __
- $a 3
- BAS __
- $a PreBMC
- BMC __
- $a 2019 $b 43 $c 9 $d 1264-1272 $e - $i 1532-0979 $m The American journal of surgical pathology $n Am J Surg Pathol $x MED00000304
- LZP __
- $a Pubmed-20201125
