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Bioavailability and structural study of 20-hydroxyecdysone complexes with cyclodextrins
BS. Temirgaziyev, K. Kučáková, YA. Baizhigit, M. Jurášek, P. Džubák, M. Hajdúch, B. Dolenský, PB. Drašar, BI. Tuleuov, SM. Adekenov,
Jazyk angličtina Země Spojené státy americké
Typ dokumentu časopisecké články, práce podpořená grantem
- MeSH
- biologická dostupnost MeSH
- cyklodextriny chemie MeSH
- ekdysteron chemie izolace a purifikace farmakokinetika MeSH
- magnetická rezonanční spektroskopie MeSH
- molekulární konformace MeSH
- rozpustnost MeSH
- Silene chemie MeSH
- Publikační typ
- časopisecké články MeSH
- práce podpořená grantem MeSH
20-Hydroxyecdysterone - (2β,3β,5β,22R)-2,3,14,20,22,25-hexahydroxycholest-7-en-6-one was isolated in satisfactory yield using ethanol extraction from the aerial part of Silene wolgensis (Hornem.) Otth; sometimes Silene wolgensis (Willd.) Bess. ex Spreng. The complexation of the phytoecdysteroid with β-cyclodextrin was studied by NMR spectroscopy. By studying the changes in chemical shifts of protons of substrates and receptors it was found that ecdysterone interacts with cyclodextrins to form supramolecular inclusion complexes of stoichiometric composition of 1:1 or 1:2. Ecdysterone-β-cyclodextrin complexes exhibit 100 times higher solubility in water than the parent compound.
Buketov Karaganda State University 100028 Karaganda Kazakhstan
International Research and Production Holding Phytochemistry 470000 Karaganda Kazakhstan
University of Chemistry and Technology Prague 166 28 Praha 6 Czech Republic
Citace poskytuje Crossref.org
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