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Whole-genome resequencing of wild and domestic sheep identifies genes associated with morphological and agronomic traits
X. Li, J. Yang, M. Shen, XL. Xie, GJ. Liu, YX. Xu, FH. Lv, H. Yang, YL. Yang, CB. Liu, P. Zhou, PC. Wan, YS. Zhang, L. Gao, JQ. Yang, WH. Pi, YL. Ren, ZQ. Shen, F. Wang, J. Deng, SS. Xu, H. Salehian-Dehkordi, E. Hehua, A. Esmailizadeh, M....
Language English Country Great Britain
Document type Journal Article, Research Support, Non-U.S. Gov't
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- MeSH
- Alleles MeSH
- Animal Husbandry methods MeSH
- Breeding MeSH
- Platelet-Derived Growth Factor metabolism MeSH
- Animals, Wild genetics MeSH
- Species Specificity MeSH
- Phenotype MeSH
- Gene Frequency MeSH
- Genetic Variation MeSH
- Genetics MeSH
- Genomics MeSH
- Genotype MeSH
- Polymorphism, Single Nucleotide MeSH
- Mutation MeSH
- Sheep, Domestic genetics MeSH
- Sheep MeSH
- Sequence Analysis, DNA MeSH
- Whole Genome Sequencing MeSH
- Selection, Genetic MeSH
- Linkage Disequilibrium MeSH
- High-Throughput Nucleotide Sequencing MeSH
- Animals MeSH
- Check Tag
- Female MeSH
- Animals MeSH
- Publication type
- Journal Article MeSH
- Research Support, Non-U.S. Gov't MeSH
Understanding the genetic changes underlying phenotypic variation in sheep (Ovis aries) may facilitate our efforts towards further improvement. Here, we report the deep resequencing of 248 sheep including the wild ancestor (O. orientalis), landraces, and improved breeds. We explored the sheep variome and selection signatures. We detected genomic regions harboring genes associated with distinct morphological and agronomic traits, which may be past and potential future targets of domestication, breeding, and selection. Furthermore, we found non-synonymous mutations in a set of plausible candidate genes and significant differences in their allele frequency distributions across breeds. We identified PDGFD as a likely causal gene for fat deposition in the tails of sheep through transcriptome, RT-PCR, qPCR, and Western blot analyses. Our results provide insights into the demographic history of sheep and a valuable genomic resource for future genetic studies and improved genome-assisted breeding of sheep and other domestic animals.
CSIRO Livestock Industries St Lucia Brisbane QLD Australia
Department of Animal Science Faculty of Agriculture Shahid Bahonar University of Kerman Kerman Iran
Department of Biological Sciences University of Alberta Edmonton Alberta T6G 2E9 Canada
Faculty of Veterinary Medicine Utrecht University Utrecht the Netherlands
Institute of Animal Breeding and Genetics Justus Liebig University Giessen Germany
Institute of Molecular Genetics of the ASCR v v i Vídeňská 1083 142 20 Prague 4 Czech Republic
Institute of Sheep and Goat Science Nanjing Agricultural University Nanjing 210095 China
Novogene Bioinformatics Institute Beijing 100083 China
Production Systems Natural Resources Institute Finland FI 31600 Jokioinen Finland
Shandong Binzhou Academy of Animal Science and Veterinary Medicine Binzhou 256600 China
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